Diagnostic evaluation of plasma aldosterone concentration
to plasma renin activity ratio in primary aldosteronism

doi:10.1007/s11684-008-0003-4

Front. Med.

2008, Vol. 2

Issue (1) : 11-14 https://doi.org/10.1007/s11684-008-0003-4

Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

Cardiovascular Department of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

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Abstract Using the plasma aldosterone concentration to plasma renin activity ratio (PAC/PRA ratio) as the screening test of choice for primary aldosteronism in hypertensive patients, we studied the clinical characteristics and the diagnostic value of PAC/PRA ratio in primary aldosteronism. The plasma aldosterone concentration (PAC) and plasma renin activity (PRA) levels were measured by radioimmunoassay in 902 hypertensive patients from out-patient clinics or hospitals. One hundred and twenty-six suspected primary aldosteronism patients whose PAC/PRA ratio was > 25 ng/dL/ng/mL/hr had a lamellar computed tomography (CT) scan in the adrenal gland and follow-up visits. The proportion of primary aldosteronism in hypertensive patients was 14% (126/902). There were 54 patients with unilateral or bilateral hyperplasia and 25 patients with adenoma according to the CT scan. 39% (49/126) of the patients with primary aldosteronism had hypokalemia. Twenty-five patients received surgical treatment. The efficacy and cure rates were 100% (25/25) and 48% (12/25), respectively. The effective rate of aldactone and the single-drug cure rate were 89% (48/54) and 24% (13/54), respectively. Primary aldosteronism affects over 10% of hypertensive patients in China. The PAC/PRA ratio can be considered as a routine screening test in hypertensives, especially resistant hypertensive patients and a high PAC/PRA ratio is an invaluable index in primary aldosteronism diagnosis.

Issue Date: 05 March 2008

Cite this article:

WANG Daowen,ZHANG Huilan. Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism[J]. Front. Med., 2008, 2(1): 11-14.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-008-0003-4
https://academic.hep.com.cn/fmd/EN/Y2008/V2/I1/11

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