|
|
Clinical and genetic risk factors for venous
thromboembolism in Chinese population |
Chen WANG PhD, MD1,Zhen-Guo ZHAI PhD, MD1,Ying H. SHEN PhD, MD2,Lan ZHAO PhD, MD3, |
1.Beijing Institute of
Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical
University, Beijing 100020, China; 2.Baylor College of Medicine,
Houston, TX 77004, USA; 3.Department of Experimental
Medicine and Toxicology, Hammersmith Hospital, Imperial College London,
London W12 0NN, UK; |
|
|
Abstract Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, carries significant mortality and morbidity. The most important and effective way to reduce VTE incidence is to identify the patients at risk and give necessary prevention. VTE is a multifactorial and complicated disorder. Major risk factors for VTE include surgery and trauma, acute medical illness, active cancer and pregnancy. Genetic factors increase susceptibility to the disease and are useful in predicting the development of VTE. Gene-gene and gene-environment interactions alter and magnify the clinical picture in this disorder. This brief review summarizes some selected clinical and genetic risk factors for VTE based on the current research in China.
|
Keywords
risk factor
stroke
prothrombin
plasminogen activator inhibitor type-1
polymorphism
thrombophilia
biomarker
|
Issue Date: 05 March 2010
|
|
|
Heit J A. The epidemiology of venous thromboembolism in the community. Arterioscler Thromb Vasc Biol, 2008, 28(3): 370–372
|
|
Silverstein M D, Heit J A, Mohr D N, Petterson T M, O'Fallon W M, Melton L J III. Trends in the incidence of deep vein thrombosis and pulmonaryembolism: a 25-year population-based study. Arch Intern Med, 1998, 158: 585–593
|
|
Cohen A T, Agnelli G, Anderson F A, Arcelus J I, Bergqvist D, Brecht J G, Greer I A, Heit J A, Hutchinson J L, Kakkar A K, Mottier D, Oger E, Samama M M, Spannagl M. VTEImpact Assessment Group in Europe (VITAE). Venous thromboembolism(VTE) in Europe. The number of VTE events and associated morbidityand mortality. Thromb Haemost, 2007, 98(4): 756–764
|
|
Cheng T O. Medicine in modern China. J Am Geriatr Soc, 1973, 21: 289–313
|
|
Cheng T O. Increasing incidence of pulmonary embolism in China:another price of modernization. Int J Cardiol, 2007, 120(2): 143–144
|
|
Tan X Y, He J G, Zou Z P, Zhao Y F, Chen B P, Gao Y, Xiong C M, Ni X H, Cheng X S. Changes of the proportion and mortality of pulmonary thromboembolismin hospitalized patients from 1974 to 2005. Chin Med J (Engl), 2006, 119(12): 998–1002
|
|
Cai B, Xu L, Guo S. Trends of underline diseases of pulmonaryembolism from Peking Union Medical College Hospital. Zhonghua Jie He He Hu Xi Za Zhi, 2001, 24(12): 715–717 (in Chinese)
|
|
Cushman M. Epidemiology and risk factors for venous thrombosis. Semin Hematol, 2007, 44(2): 62–69
|
|
Greer I A. Inherited thrombophilia and venous thromboembolism. Best Pract Res Clin Obstet Gynaecol, 2003, 17(3): 413–425
|
|
Margaglione M, Brancaccio V, De Lucia D, Martinelli I, Ciampa A, Grandone E, Di Minno G. Inherited thrombophilic risk factors and venous thromboembolism:distinct role in peripheral deep venous thrombosis and pulmonary embolism. Chest, 2000, 118(5): 1405–1411
|
|
Douketis J D, Moinuddin I. Prophylaxisagainst venous thromboembolism in hospitalized medical patients: anevidence-based and practical approach. Pol Arch Med Wewn, 2008, 118(4): 209–215
|
|
Prandoni P, Samama M M. Risk stratification and venous thromboprophylaxis in hospitalizedmedical and cancer patients. Br J Haematol, 2008, 141(5): 587–597
|
|
Sun K K, Wang C, Guli X T, Luo Q. Riskfactors and clinical features of deep venous thrombosis: a reportof 388 cases. Zhonghua Jie He He Hu XiZa Zhi, 2004, 27(11): 727–730 (in Chinese)
|
|
Li X L, Lu W J, Yu N S, Lu Y H, Lin Z Q, Dong W Q. Prophylaxis for deep vein thrombosis with low molecularheparin following hip and knee surgery. Zhongguo Xiufu Chongjian Waike Zazhi, 2001, 15 (1): 39–41 (in Chinese)
|
|
Guan Z P, Lü H S, Chen Y Z, Song Y N, Qin X L, Jiang J. Clinical risk factors for deep vein thrombosisafter total hip and knee arthroplasty. Zhonghua Wai Ke Za Zhi, 2005, 43(20): 1317–1320 (in Chinese)
|
|
Ko P S, Chan W F, Siu T H, Khoo J, Wu W C, Lam J J. Deep venous thrombosis after total hip or knee arthroplastyin a “low-risk” Chinese population. J Arthroplasty, 2003, 18(2): 174–179
|
|
Lee F Y, Chu W, Chan R, Leung Y F, Liu K H, Ng S M, Lai P B, Metreweli C, Lau W Y. Incidence of deep vein thrombosis after colorectal surgery in a Chinesepopulation. ANZ J Surg, 2001, 71(11): 637–640
|
|
Sun K K, Wang C, Pang B S, Yang Y H, He W, Chen T F, Zhao Q H, Zhang J. Study on the risk factors of deep venousthrombosis in acute hospitalized stroke patients. Zhonghua Liu Xing Bing Xue Za Zhi, 2004, 25(12): 1019–1023 (in Chinese)
|
|
Sun K K, Wang C, Pang B S, Yang Y H. The prevalence of deep venous thrombosis in hospitalized patientswith stroke. Zhonghua Yi Xue Za Zhi, 2004, 84(8): 637–641 (in Chinese)
|
|
Xu X F, Yang Y H, Zhai Z G, Liu S, Zhu G F, Li C S, Wang C. Prevalenceand incidence of deep venous thrombosis among patients in medicalintensive care unit. Zhonghua Liu XingBing Xue Za Zhi, 2008, 29(10): 1034–1037 (in Chinese)
|
|
Joynt G M, Li T S, Griffith J F, Gomersall C D, Yap F H, Ho A M, Leung P. Theincidence of deep venous thrombosis in Chinese medical intensive careunit patients. Hong Kong Med J, 2009, 15(1): 24–30
|
|
Chan L Y, Yuen P M, Lo W K, Lau T K. Symptomatic venous thromboembolism in Chinese patients after gynecologicsurgery: incidence and disease pattern. Acta Obstet Gynecol Scand, 2002, 81(4): 343–346
|
|
Egeberg O. Thrombophlia caused by inherited deficiency of bloodantithrombin. Scand J Clin Lab Invest, 1965, 17: 92
|
|
Simioni P, Scudeller A, Girolami A. Factor V Leiden and thrombophilia. N Engl J Med, 1995, 332(20): 1382
|
|
Reitsma P H. Genetic heterogeneity in hereditary thrombophilia. Haemostasis, 2000, 30(Suppl 2): 1–10
|
|
Murin S, Marelich G P, Arroliga A C, Matthay R A. Hereditary thrombophilia and venous thromboembolism. Am J Respir Crit Care Med, 1998, 158(5 Pt 1): 1369–1373
|
|
Poort S R, Rosendaal F R, Reitsma P H, Bertina R M. A common genetic variation in the 3'-untranslated regionof the prothrombin gene is associated with elevated plasma prothrombinlevels and an increase in venous thrombosis. Blood, 1996, 88(10): 3698–3703
|
|
Zhai Z, Wang C, Yang Y H, Pang B S, Xiao B, Liu Y M, Mao Y L, Weng X Z. The relationship between polymorphismsof prothrombin G20210 and pulmonary thromboembolism in Chinese Hanpopulation. Shoudu Yike Daxue Xuebao, 2006, (1): 1–5 (in Chinese)
|
|
Jun Z J, Ping T, Lei Y, Li L, Ming S Y, Jing W. Prevalence of factor V Leiden and prothrombin G20210Amutations in Chinese patients with deep venous thrombosis and pulmonaryembolism. Clin Lab Haematol, 2006, 28(2): 111–116
|
|
Chan D K, Hu G, Tao H, Owens D, Vun C M, Woo J, Chong B H. A comparisonof polymorphism in the 3'-untranslated region of the prothrombin genebetween Chinese and Caucasians in Australia. Br J Haematol, 2000, 111(4): 1253–1255
|
|
Zhai Z G, Wang C, Yang Y H, Pang B S, Xiao B, Liu Y M, Mao Y L. Study onthe relationship between polymorphisms of susceptible genes in coagulationpathway related to pulmonary thromboembolism in Chinese Han population. Zhonghua Liu Xing Bing Xue Za Zhi, 2006, 27(2): 165–169 (in Chinese)
|
|
Zhai Z G, Wang C, Yang Y H, Pang B S, Xiao B, Liu Y M, Mao Y L, Weng X Z. Relationship between polymorphisms ofplasminogen activator inhibitor-1 promoter gene and pulmonary thromboembolismin Chinese Han population. Zhonghua YiXue Za Zhi, 2006, 86(19): 1313–1317 (in Chinese)
|
|
Han X M, Ren J F, Hao B, Cao W D, Liu X E, Hou L H, Guo Z P, Yu B, Wang X F, Ding Q L, Yang L H. Analysis of activated protein C resistance, factor V coagulationactivity and gene polymorphisms in patients with venous thromboembolism. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2007, 15(3): 612–616 (in Chinese)
|
|
Lu Y, Zhao Y, Liu G, Wang X, Liu Z, Chen B, Hui R. Factor V geneG1691A mutation, prothrombin gene G20210A mutation, and MTHFR geneC677T mutation are not risk factors for pulmonary thromboembolismin Chinese population. Thromb Res, 2002, 106(1): 7–12
|
|
Lu Y, Hui R, Zhao Y. Insertion/deletion polymorphsim of theangiotensin I converting enzyme gene and pulmonary thromboembolismin Chinese population. Zhonghua Jie HeHe Hu Xi Za Zhi, 2001, 24(5): 265–268 (in Chinese)
|
|
Le Flem L, Mennen L, Aubry M L, Aiach M, Scarabin P Y, Emmerich J, Alhenc-Gelas M. Thrombomodulin promoter mutations, venous thrombosis,and varicose veins. Arterioscler ThrombVasc Biol, 2001, 21(3): 445–451
|
|
Uitte de Willige S, Van Marion V, Rosendaal F R, Vos H L, de Visser M C, Bertina R M. Haplotypes of the EPCR gene,plasma sEPCR levels and the risk of deep venous thrombosis. J Thromb Haemost, 2004, 2(8): 1305–1310
|
|
Zhai Z, Yin Y, Yang Y, Wang J, Wang C, Xi W. The association between thrombomodulin gene variationsand thromboembolic pulmonary hypertension. Am J Respir Crit Care Med, 2009, 179: A3339
|
|
Nelson S M, Greer I A. Thrombophiliaand the risk for venous thromboembolism during pregnancy, delivery,and puerperium. Obstet Gynecol Clin NorthAm, 2006, 33(3): 413–427
|
|
Martinelli I, Taioli E, Battaglioli T, Podda G M, Passamonti S M, Pedotti P, Mannucci P M. Risk of venous thromboembolism after air travel: interactionwith thrombophilia and oral contraceptives. Arch Intern Med, 2003, 163(22): 2771–2774
|
|
Pang B S, Wang C, Zhai Z G, Yang Y H, Mao Y L, Huang X X, Zhu J. Changes ofblood coagulative and fibrinolytic systems and functions of pulmonaryvascular endothelium in patients with pulmonary thromboembolism. Zhonghua Jie He He Hu Xi Za Zhi, 2005, 28(10): 714–716 (in Chinese)
|
|
Pang B S, Wang C, Lu Y, Yang Y H, Xing G H, Mao Y L, Huang X X, Zhai Z G. Changes of blood coagulative and fibrinolytic systemand function of pulmonary vascular endothelium after therapy in patientswith acute pulmonary thromboembolism. ZhonghuaYi Xue Za Zhi, 2007, 87(43): 3074–3078 (in Chinese)
|
|
Yin Y D, Wang C, Zhai Z G, Pang B S, Yang Y H, Huang X X. Decreased plasma soluble thrombomodulin levels as a riskfactor for pulmonary thromboembolism. JThromb Thrombolysis, 2009, 27(3): 274–279
|
|
Hong M, Zhang X, Hu Y, Wang H, He W, Mei H, Yu J, Guo T, Song S. The potential biomarkers for thromboembolismdetected by SELDI-TOF-MS. Thromb Res, 2009, 123(3): 556–564
|
|
Yang G, Lu H, Gao J, Kou B, Yuan Y, Xu B. Low-molecular-weight heparin for preventing deep-veinthrombosis after total joint arthroplasty. Zhonghua Wai Ke Za Zhi, 2000, 38(1): 25–27 (in Chinese)
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|