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Cyclooxygenase-2 gene-1195G/A genotype is associated
with the risk of HBV-induced HCC: A case-control study in Han Chinese
people |
Li-Feng LIU MD, PhD1,Qiong CHEN MD, PhD1,Ying CHANG MD, PhD1,Ju-Sheng LIN MD, PhD1,Jin-Liang ZHANG MM2, |
1.Institute of Liver
Disease, Tongji Hospital, Tongji Medical College, Huazhong University
of Science and Technology, Wuhan 430030, China; 2.Department of Hepatic
Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong
University of Science and Technology, Wuhan 430030, China; |
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Abstract This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infection. We conducted a population-based, case-control study enrolling 630 Han Chinese people in Hubei province. Subjects included primary HCC patients with HBV infection (n=210), chronic hepatitis B cases (n=210) and healthy Han Chinese (n=210). -1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis. We found-1195A allele carriers had a higher risk of HCC with HBV infection (OR, 0.72; 95% CI, 0.548–0.946). The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.
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Keywords
cyclooxygenase-2 gene
single nucleotide polymorphisms
susceptibility
primary hepatocellular carcinoma
hepatitis B virus infection
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Issue Date: 05 March 2010
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