|
|
The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis of infantile persistent jaundice |
Sheng-Xuan LIU, Zhi-Hua HUANG() |
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
|
|
Abstract The aim of this study was to investigate the value of technetium etifenin injection (99mTc-EHIDA) hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis between infantile hepatitis syndrome and biliary atresia. 99mTc-EHIDA hepatobiliary scintigraphy in combination with duodenal fluid examination was used for evaluation in 84 infants with persistent infantile jaundice. For diagnosing biliary atresia, the sensitivity and specificity of scintigraphy were 100% and 74.5%, respectively; the sensitivity and specificity of scintigraphy in combination with duodenal fluid examination were 100% and 100%, respectively. In conclusion, hepatobiliary scintigraphy, which is a noninvasive, safe, valuable examination method, in combination with examination of duodenal fluid, is of value for the differential diagnosis between infantile hepatitis syndrome and biliary atresia.
|
Keywords
jaundice
radionuclide hepatobiliary scintigraphy
duodenal drainage
|
Corresponding Author(s):
HUANG Zhi-Hua,Email:zhhuang@tjh.tjmu.edu.cn
|
Issue Date: 05 September 2010
|
|
1 |
Huang Z H, Dong Y C. Dynamic duodenal fluid examination differential diagnose infantile continuous obstructive jaundice. Zhonghua Er Ke Za Zhi , 2004, 42(1): 54–56 (in Chinese)
|
2 |
Lee C H, Wang P W, Lee T T, Tiao M M, Huang F C, Chuang J H, Shieh C S, Cheng Y F. The significance of functioning gallbladder visualization on hepatobiliary scintigraphy in infants with persistent jaundice. J Nucl Med , 2000, 41(7): 1209–1213
|
3 |
Gerhold J P, Klingensmith W C 3rd, Kuni C C, Lilly J R, Silverman A, Fritzberg A R, Nixt T L. Diagnosis of biliary atresia with radionuclide hepatobiliary imaging. Radiology , 1983, 146(2): 499–504
|
4 |
Nadel H R. Hepatobiliary scintigraphy in children. Semin Nucl Med , 1996, 26(1): 25–42 doi: 10.1016/S0001-2998(96)80014-6
|
5 |
Charearnrad P, Chongsrisawat V, Tepmongkol S, Poovorawan Y. The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome. J Med Assoc Thai , 2003, 86(Suppl 2): S189–S194
|
6 |
Esmaili J, Izadyar S, Karegar I, Gholamrezanezhad A. Biliary atresia in infants with prolonged cholestatic jaundice: diagnostic accuracy of hepatobiliary scintigraphy. Abdom Imaging , 2007, 32(2): 243–247 doi: 10.1007/s00261-006-9049-4
|
7 |
Poddar U, Bhattacharya A, Thapa B R, Mittal B R, Singh K. Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med , 2004, 45(9): 1488–1492
|
8 |
Fischler B, Woxenius S, Nemeth A, Papadogiannakis N. Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection. J Pediatr Surg , 2005, 40(3): 541–546 doi: 10.1016/j.jpedsurg.2004.11.035
|
9 |
Fjaer R B, Bruu A L, Nordb? S A. Extrahepatic bile duct atresia and viral involvement. Pediatr Transplant , 2005, 9(1): 68–73 doi: 10.1111/j.1399-3046.2005.00257.x
|
10 |
Stipsanelli K, Koutsikos J, Papantoniou V, Arka A, Palestidis C, Tsiouris S, Manolaki A, Zerva C. Hepatobiliary scintigraphy and gamma-GT levels in the differential diagnosis of extrahepatic biliary atresia. Q J Nucl Med Mol Imaging , 2007, 51(1): 74–81
|
11 |
Greene H L, Helinek G L, Moran R, O’Neill J. A diagnostic approach to prolonged obstructive jaundice by 24-hour collection of duodenal fluid. J Pediatr , 1979, 95(3): 412–414 doi: 10.1016/S0022-3476(79)80519-3
|
12 |
Faweya A G, Akinyinka O O, Sodeinde O. Duodenal intubation and aspiration test: utility in the differential diagnosis of infantile cholestasis. J Pediatr Gastroenterol Nutr , 1991, 13(3): 290–292 doi: 10.1097/00005176-199110000-00009
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|