Assessment of liver volume variation to evaluate liver function

doi:10.1007/s11684-012-0223-5

Front Med

2012, Vol. 6

Issue (4) : 421-427 https://doi.org/10.1007/s11684-012-0223-5

RESEARCH ARTICLE

Assessment of liver volume variation to evaluate liver function

Cong Tong¹, Xinsen Xu¹, Chang Liu¹(

), Tianzheng Zhang², Kai Qu¹

1. Department of Hepatobiliary Surgery, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, China; 2. Department of Surgery, Shaanxi Xianyang 215 Hospital, Xianyang 712000, China

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Abstract

In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patients, we explored the correlation between hepatic volume and severity of the hepatic diseases. The clinical data of 48 cirrhosis patients with 60 normal controls and 39 ALF patients were collected. Computed tomography-derived liver volume (CTLV) and body surface area (BSA) of normal controls were calculated to get a regression formula for standard liver volume (SLV) and BSA. Then CTLV and SLV of all patients were calculated and grouped by Child-Turcotte-Pugh classification for cirrhosis patients and assigned according to prognosis of ALF patients for further comparison. It turned out that the mean liver volume of the control group was 1 058±337 cm³. SLV was correlated with BSA according to the regression formula. The hepatic volume of cirrhosis patients in Child A, B level was not reduced, but in Child C level it was significantly reduced with the lowest liver volume index (CTLV/SLV). Likewise, in the death group of ALF patients, the volume index was significantly lower than that of the survival group. Based on volumetric study, we proposed an ROC (receiver operating characteristic) analysis to predict the prognosis of ALF patients that CTLV/SLV<83.9% indicates a poor prognosis. In conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liver function and progression of cirrhosis and ALF. It is also a very useful marker for predicting the prognosis of ALF.

Keywords liver volume variation cirrhosis acute liver failure (ALF)

Corresponding Author(s): Liu Chang,Email:liuchangdoctor@163.com

Issue Date: 05 December 2012

Cite this article:

Cong Tong,Xinsen Xu,Chang Liu, et al. Assessment of liver volume variation to evaluate liver function[J]. Front Med, 2012, 6(4): 421-427.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-012-0223-5
https://academic.hep.com.cn/fmd/EN/Y2012/V6/I4/421

Fig.1 Volumetric analysis of the liver. (A) To outline the edge of the liver on each slice of the CT films with a cursorB) Reconstruction of the liver by adding the area of each slice from the most superior part to the most inferior part.

Tab.1 Baseline characteristics of the patients

Tab.2 Correlation between cirrhotic liver volume index and liver function

Fig.2 Difference of the volume index between different cirrhosis Child classes.

Tab.3 Correlation between ALF liver volume index and liver function

Fig.3 Difference of the volume index between different ALF prognosis.

Fig.4 ROC analysis of the ALF volume index.

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