|
|
Sepsis biomarkers: an omics perspective |
Xiao Liu1,2, Hui Ren2(), Daizhi Peng1() |
1. Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing 400038, China; 2. School of Nursing, Third Military Medical University, Chongqing 400038, China |
|
|
Abstract Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi-omics approach to disease identification.
|
Keywords
sepsis
biomarker
genomics
transcriptomics
proteomics
metabolomics
|
Corresponding Author(s):
Ren Hui,Email:renhui_tmmu@163.com; Peng Daizhi,Email:dzpengmd@126.com
|
Issue Date: 26 April 2014
|
|
1 |
Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang M. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34(6): 1589–1596 doi: 10.1097/01.CCM.0000217961.75225.E9 pmid:16625125
|
2 |
Reinhart K, Bauer M, Riedemann NC, Hartog CS. New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev 2012; 25(4): 609–634 doi: 10.1128/CMR.00016-12 pmid:23034322
|
3 |
Cohen J. The immunopathogenesis of sepsis. Nature 2002; 420(6917): 885–891 doi: 10.1038/nature01326 pmid:12490963
|
4 |
Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, Vadas L, Pugin J; Geneva Sepsis Network.. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001; 164(3): 396–402 doi: 10.1164/ajrccm.164.3.2009052 pmid:11500339
|
5 |
Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 2004; 39(2): 206–217 doi: 10.1086/421997 pmid:15307030
|
6 |
Bozza FA, Salluh JI, Japiassu AM, Soares M, Assis EF, Gomes RN, Bozza MT, Castro-Faria-Neto HC, Bozza PT. Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care 2007; 11(2): R49 doi: 10.1186/cc5783 pmid:17448250
|
7 |
Vaschetto R, Nicola S, Olivieri C, Boggio E, Piccolella F, Mesturini R, Damnotti F, Colombo D, Navalesi P, Della Corte F, Dianzani U, Chiocchetti A. Serum levels of osteopontin are increased in SIRS and sepsis. Intensive Care Med 2008; 34(12): 2176–2184 doi: 10.1007/s00134-008-1268-4 pmid:18807011
|
8 |
Brenner T, Rosenhagen C, Steppan J, Lichtenstern C, Weitz J, Bruckner T, Martin EO, Hoffmann U, Weigand MA, Hofer S. Redox responses in patients with sepsis: high correlation of thioredoxin-1 and macrophage migration inhibitory factor plasma levels. Mediators Inflamm 2010; 2010: 985614 doi: 10.1155/2010/985614 pmid:20847814
|
9 |
Bae JS. Role of high mobility group box 1 in inflammatory disease: focus on sepsis. Arch Pharm Res 2012; 35(9): 1511–1523 doi: 10.1007/s12272-012-0901-5 pmid:23054707
|
10 |
Wu Y, Wang F, Fan X, Bao R, Bo L, Li J, Deng X. Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis. Crit Care 2012; 16(6): R229 doi: 10.1186/cc11884 pmid:23194114
|
11 |
Backes Y, van der Sluijs KF, Mackie DP, Tacke F, Koch A, Tenhunen JJ, Schultz MJ. Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review. Intensive Care Med 2012; 38(9): 1418–1428 doi: 10.1007/s00134-012-2613-1 pmid:22706919
|
13 |
Lobo SM, Lobo FR, Bota DP, Lopes-Ferreira F, Soliman HM, Mélot C, Vincent JL. C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest 2003; 123(6): 2043–2049 doi: 10.1378/chest.123.6.2043 pmid:12796187
|
14 |
Komiya K, Ishii H, Teramoto S, Takahashi O, Yamamoto H, Oka H, Umeki K, Kadota J.Plasma C-reactive protein levels are associated with mortality in elderly with acute lung injury. J Crit Care 2012; 27(5): 524 e521–526
|
15 |
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31(4): 1250–1256 doi: 10.1097/01.CCM.0000050454.01978.3B pmid:12682500
|
16 |
Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis 2013; 13(5): 426–435 doi: 10.1016/S1473-3099(12)70323-7 pmid:23375419
|
17 |
Kofoed K, Andersen O, Kronborg G, Tvede M, Petersen J, Eugen-Olsen J, Larsen K. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care 2007; 11(2): R38 doi: 10.1186/cc5723 pmid:17362525
|
18 |
Xiong C, McKeel DW, Jr., Miller JP, Morris JC. Combining correlated diagnostic tests: application to neuropathologic diagnosis of Alzheimer's disease. Medical decision making: an international journal of the Society for Medical Decision Making , 2004, 24(6): 659–669
|
19 |
Gibot S, Béné MC, Noel R, Massin F, Guy J, Cravoisy A, Barraud D, De Carvalho Bittencourt M, Quenot JP, Bollaert PE, Faure G, Charles PE. Combination biomarkers to diagnose sepsis in the critically ill patient. Am J Respir Crit Care Med 2012; 186(1): 65–71 doi: 10.1164/rccm.201201-0037OC pmid:22538802
|
20 |
Wong HR. Genetics and genomics in pediatric septic shock. Crit Care Med 2012; 40(5): 1618–1626 doi: 10.1097/CCM.0b013e318246b546 pmid:22511139
|
21 |
Sutherland AM, Walley KR, Manocha S, Russell JA. The association of interleukin 6 haplotype clades with mortality in critically ill adults. Arch Intern Med 2005; 165(1): 75–82 doi: 10.1001/archinte.165.1.75 pmid:15642878
|
22 |
Thompson CM, Holden TD, Rona G, Laxmanan B, Black RA, O’Keefe GE, Wurfel MM. Toll-like receptor 1 polymorphisms and associated outcomes in sepsis after traumatic injury: a candidate gene association study. Ann Surg 2014; 259(1): 179–185 doi: 10.1097/SLA.0b013e31828538e8 pmid:23478521
|
23 |
Cornell TT, Wynn J, Shanley TP, Wheeler DS, Wong HR. Mechanisms and regulation of the gene-expression response to sepsis. Pediatrics 2010; 125(6): 1248–1258 doi: 10.1542/peds.2009-3274 pmid:20478944
|
24 |
de Aguiar BB, Girardi I, Paskulin DD, de Franca E, Dornelles C, Dias FS, Bonorino C, Alho CS. CD14 expression in the first 24h of sepsis: effect of –260C→T CD14 SNP. Immunol Invest 2008; 37(8): 752–769 doi: 10.1080/08820130802403242 pmid:18991094
|
25 |
Fallavena PR, Borges TJ, Paskulin DD, Paludo FJO, Goetze TB, de Oliveira JR, Nóbrega OT, Dias FS, Alho CS. The influences of CD14 –260C→T polymorphism on survival in ICU critically ill patients. Immunol Invest 2009; 38(8): 797–811 doi: 10.3109/08820130903258818 pmid:19860589
|
26 |
Heesen M, Bloemeke B, Schade U, Obertacke U, Majetschak M. The –260 C→T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients. Intensive Care Med 2002; 28(8): 1161–1163 doi: 10.1007/s00134-002-1389-0 pmid:12185442
|
27 |
Barber RC, Aragaki CC, Rivera-Chavez FA, Purdue GF, Hunt JL, Horton JW. TLR4 and TNF-α polymorphisms are associated with an increased risk for severe sepsis following burn injury. J Med Genet 2004; 41(11): 808–813 doi: 10.1136/jmg.2004.021600 pmid:15520404
|
29 |
Zeng L, Gu W, Zhang AQ, Zhang M, Zhang LY, Du DY, Huang SN, Jiang JX. A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. Ann Surg 2012; 255(1): 147–157 doi: 10.1097/SLA.0b013e3182389515 pmid:22167001
|
30 |
Cardinal-Fernández P, Ferruelo A, El-Assar M, Santiago C, Gómez-Gallego F, Martín-Pellicer A, Frutos-Vivar F, Pe?uelas O, Nin N, Esteban A, Lorente JA. Genetic predisposition to acute kidney injury induced by severe sepsis. J Crit Care 2013; 28(4): 365–370 doi: 10.1016/j.jcrc.2012.11.010 pmid:23499421
|
31 |
Baier RJ, Loggins J, Yanamandra K. IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants. BMC Med 2006; 4(1): 10 doi: 10.1186/1741-7015-4-10 pmid:16611358
|
32 |
Jilma B, Marsik C, Kovar F, Wagner OF, Jilma-Stohlawetz P, Endler G. The single nucleotide polymorphism Ser128Arg in the E-selectin gene is associated with enhanced coagulation during human endotoxemia. Blood 2005; 105(6): 2380–2383 doi: 10.1182/blood-2004-09-3752 pmid:15546947
|
33 |
Geishofer G, Binder A, Müller M, Z?hrer B, Resch B, Müller W, Faber J, Finn A, Endler G, Mannhalter C, Zenz W; Central European Meningococcal Genetic Study Group. 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene in children with systemic meningococcaemia. Eur J Pediatr 2005; 164(8): 486–490 doi: 10.1007/s00431-005-1673-4 pmid:15843979
|
34 |
Gunderson KL, Steemers FJ, Lee G, Mendoza LG, Chee MS. A genome-wide scalable SNP genotyping assay using microarray technology. Nat Genet 2005; 37(5): 549–554 doi: 10.1038/ng1547 pmid:15838508
|
35 |
Hoffmann TJ, Kvale MN, Hesselson SE, Zhan Y, Aquino C, Cao Y, Cawley S, Chung E, Connell S, Eshragh J, Ewing M, Gollub J, Henderson M, Hubbell E, Iribarren C, Kaufman J, Lao RZ, Lu Y, Ludwig D, Mathauda GK, McGuire W, Mei G, Miles S, Purdy MM, Quesenberry C, Ranatunga D, Rowell S, Sadler M, Shapero MH, Shen L, Shenoy TR, Smethurst D, Van den Eeden SK, Walter L, Wan E, Wearley R, Webster T, Wen CC, Weng L, Whitmer RA, Williams A, Wong SC, Zau C, Finn A, Schaefer C, Kwok PY, Risch N. Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics 2011; 98(2): 79–89 doi: 10.1016/j.ygeno.2011.04.005 pmid:21565264
|
36 |
Arcaroli J, Fessler MB, Abraham E. Genetic polymorphisms and sepsis. Shock 2005; 24(4): 300–312 doi: 10.1097/01.shk.0000180621.52058.e1 pmid:16205313
|
37 |
Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An operational definition of epigenetics. Genes Dev 2009; 23(7): 781–783 doi: 10.1101/gad.1787609 pmid:19339683
|
38 |
Delcuve GP, Rastegar M, Davie JR. Epigenetic control. J Cell Physiol 2009; 219(2): 243–250 doi: 10.1002/jcp.21678 pmid:19127539
|
39 |
Wen H, Dou Y, Hogaboam CM, Kunkel SL. Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Blood 2008; 111(4): 1797–1804 doi: 10.1182/blood-2007-08-106443 pmid:18055863
|
40 |
Bierne H, Hamon M, Cossart P. Epigenetics and bacterial infections. Cold Spring Harb Perspect Med 2012; 2(12): a010272 doi: 10.1101/cshperspect.a010272 pmid:23209181
|
41 |
Laudanski K. Adoptive transfer of na?ve dendritic cells in resolving post-sepsis long-term immunosuppression. Med Hypotheses 2012; 79(4): 478–480 doi: 10.1016/j.mehy.2012.06.028 pmid:22840328
|
42 |
Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011; 306(23): 2594–2605 doi: 10.1001/jama.2011.1829 pmid:22187279
|
43 |
Carson WF, Cavassani KA, Dou Y, Kunkel SL. Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics 2011; 6(3): 273–283 doi: 10.4161/epi.6.3.14017 pmid:21048427
|
44 |
Wang X, Wang Y, Peng D, Huang W, Zhou X, Fu G. Changes in the inositol lipid signal system and effects on the secretion of TNF-α by macrophages in severely scalded mice. Burns 2011; 37(8): 1378–1385 doi: 10.1016/j.burns.2011.07.013 pmid:21855216
|
45 |
Wang Y, Peng D, Huang W, Zhou X, Liu J, Fang Y. Mechanism of altered TNF-α expression by macrophage and the modulatory effect of Panax notoginseng saponins in scald mice. Burns 2006; 32(7): 846–852 doi: 10.1016/j.burns.2006.02.001 pmid:16814471
|
46 |
Liu Y, Lin JD, Xiao XJ, Zhang BL, Lin H. An investigation of changes in gene expression profile of heart tissue in a rat sepsis model. Chin Crit Care Med (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue) 2009; 21(3): 155–159 (in Chinese) pmid:19278585
|
47 |
Li ZJ, Li YP, Gai HR, Xue YL, Feng XZ. Research of gene expression profile of liver tissue in rat sepsis model. Chin Crit Care Med (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue) 2007; 19(3): 156–159 (in Chinese) pmid:17376269
|
48 |
Cobb JP, Laramie JM, Stormo GD, Morrissey JJ, Shannon WD, Qiu Y, Karl IE, Buchman TG, Hotchkiss RS. Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. Crit Care Med 2002; 30(12): 2711–2721 doi: 10.1097/00003246-200212000-00016 pmid:12483063
|
49 |
Li L, Wang XP, Wu K. Change of gene expression spectra of leucocyte in sepsis mice. Chin J Emerg Med (Zhongguo Ji Zhen Yi Xue Za Zhi) 2005; 14(2): 122–126 (in Chinese)
|
50 |
Lukaszewski RA, Yates AM, Jackson MC, Swingler K, Scherer JM, Simpson AJ, Sadler P, McQuillan P, Titball RW, Brooks TJ, Pearce MJ. Presymptomatic prediction of sepsis in intensive care unit patients. Clin Vaccine Immunol 2008; 15(7): 1089–1094 doi: 10.1128/CVI.00486-07 pmid:18480235
|
51 |
Sutherland A, Thomas M, Brandon RA, Brandon RB, Lipman J, Tang B, McLean A, Pascoe R, Price G, Nguyen T, Stone G, Venter D. Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis. Crit Care 2011; 15(3): R149 doi: 10.1186/cc10274 pmid:21682927
|
52 |
Johnson SB, Lissauer M, Bochicchio GV, Moore R, Cross AS, Scalea TM. Gene expression profiles differentiate between sterile SIRS and early sepsis. Ann Surg 2007; 245(4): 611–621 doi: 10.1097/01.sla.0000251619.10648.32 pmid:17414611
|
53 |
Wong HR. Clinical review: Sepsis and septic shock- the potential of gene arrays. Crit Care 2012; 16(1): 204 210.1186/cc10537
|
54 |
Reid G, Kirschner MB, van Zandwijk N. Circulating microRNAs: association with disease and potential use as biomarkers. Crit Rev Oncol Hematol 2011; 80(2): 193–208 doi: 10.1016/j.critrevonc.2010.11.004 pmid:21145252
|
55 |
Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008; 18(10): 997–1006 doi: 10.1038/cr.2008.282 pmid:18766170
|
56 |
Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O’Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 2008; 105(30): 10513–10518 doi: 10.1073/pnas.0804549105 pmid:18663219
|
57 |
Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Harris AL. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 2008; 141(5): 672–675 doi: 10.1111/j.1365-2141.2008.07077.x pmid:18318758
|
58 |
Hu Z, Chen X, Zhao Y, Tian T, Jin G, Shu Y, Chen Y, Xu L, Zen K, Zhang C, Shen H. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol 2010; 28(10): 1721–1726 doi: 10.1200/JCO.2009.24.9342 pmid:20194856
|
59 |
Zhang Y, Liao Y, Wang D, He Y, Cao D, Zhang F, Dou K. Altered expression levels of miRNAs in serum as sensitive biomarkers for early diagnosis of traumatic injury. J Cell Biochem 2011; 112(9): 2435–2442 doi: 10.1002/jcb.23168 pmid:21538484
|
60 |
Lorenzen JM, Kielstein JT, Hafer C, Gupta SK, Kümpers P, Faulhaber-Walter R, Haller H, Fliser D, Thum T. Circulating miR-210 predicts survival in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol 2011; 6(7): 1540–1546 doi: 10.2215/CJN.00430111 pmid:21700819
|
61 |
Kong XY, Du YQ, Li L, Liu JQ, Wang GK, Zhu JQ, Man XH, Gong YF, Xiao LN, Zheng YZ, Deng SX, Gu JJ, Li ZS. Plasma miR-216a as a potential marker of pancreatic injury in a rat model of acute pancreatitis. World J Gastroenterol 2010; 16(36): 4599–4604 doi: 10.3748/wjg.v16.i36.4599 pmid:20857533
|
62 |
Cermelli S, Ruggieri A, Marrero JA, Ioannou GN, Beretta L. Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS ONE 2011; 6(8): e23937 doi: 10.1371/journal.pone.0023937 pmid:21886843
|
63 |
Vasilescu C, Rossi S, Shimizu M, Tudor S, Veronese A, Ferracin M, Nicoloso MS, Barbarotto E, Popa M, Stanciulea O, Fernandez MH, Tulbure D, Bueso-Ramos CE, Negrini M, Calin GA. MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS ONE 2009; 4(10): e7405 doi: 10.1371/journal.pone.0007405 pmid:19823581
|
64 |
Zeng XL, Zhang SY, Zhang JF, Li FM, Ma XL, Mi YH. Expression of microRNA-150 in peripheral blood leukocytes in sepsis patients and its clinical significance. Chin J Respir Crit Care Med (Zhongguo Hu Xi Yu Wei Zhong Jian Hu Za Zhi) 2011; 4(10): 360–364 (in Chinese)
|
65 |
Zeng XL, Zhang SY, Zhang JF, Yuan H, Wang Y. Expression of microRNA-143 in sepsis and its clinical significance. J Chin Pract Diag Ther (Zhonghua Shi Yong Zhen Duan Yu Zhi Liao Za Zhi) 2011; 11: 1063–1066 (in Chinese)
|
66 |
Wang H, Meng K, Chen W, Feng D, Jia Y, Xie L. Serum miR-574-5p: a prognostic predictor of sepsis patients. Shock 2012; 37(3): 263–267 doi: 10.1097/SHK.0b013e318241baf8 pmid:22344312
|
67 |
Wang JF, Yu ML, Yu G, Bian JJ, Deng XM, Wan XJ, Zhu KM. Serum miR-146a and miR-223 as potential new biomarkers for sepsis. Biochem Biophys Res Commun 2010; 394(1): 184–188 doi: 10.1016/j.bbrc.2010.02.145 pmid:20188071
|
68 |
Peng X, Gralinski L, Armour CD, Ferris MT, Thomas MJ, Proll S, Bradel-Tretheway BG, Korth MJ, Castle JC, Biery MC, Bouzek HK, Haynor DR, Frieman MB, Heise M, Raymond CK, Baric RS, Katze MG. Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling. MBio 2010; 1(5): e00206-10, e00206-18 doi: 10.1128/mBio.00206-10 pmid:20978541
|
69 |
Siqueira-Batista R, de Mendon?a EG, Patrícia Gomes A, Roger Vitorino R, Miyadahira R, Alvarez-Perez MC, de Almeida Oliveira MG. Proteomic updates on sepsis. Rev Assoc Med Bras 2012; 58(3): 376–382 doi: 10.1016/S0104-4230(12)70210-5 pmid:22735232
|
70 |
Zeng JZ, Zhang PH, Li LL, Ren LC, Liang PF, Huang XY. Proteomic study of peripheral blood lymphocytes of rabbits with severe burn and Pseudomonas aeruginosa sepsis. Chin Crit Care Med (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue) 2009; 21(8): 455–459 (in Chinese) pmid:19695163
|
71 |
He XD, Zou Q, Chen ZD, Yan PE. Proteomic analysis of neutrophils of rats with Acinetobacter baumannii sepsis. Chin J Microbiol Immunol (Zhonghua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi) 2012; 32(5): 385–394 (in Chinese)
|
72 |
Hattori N, Oda S, Sadahiro T, Nakamura M, Abe R, Shinozaki K, Nomura F, Tomonaga T, Matsushita K, Kodera Y, Sogawa K, Satoh M, Hirasawa H. YKL-40 identified by proteomic analysis as a biomarker of sepsis. Shock 2009; 32(4): 393–400 doi: 10.1097/SHK.0b013e31819e2c0c pmid:19197227
|
73 |
Paugam-Burtz C, Albuquerque M, Baron G, Bert F, Voitot H, Delefosse D, Dondero F, Sommacale D, Francoz C, Hanna N, Belghiti J, Ravaud P, Bedossa P, Mantz J, Paradis V. Plasma proteome to look for diagnostic biomarkers of early bacterial sepsis after liver transplantation: a preliminary study. Anesthesiology 2010; 112(4): 926–935 doi: 10.1097/ALN.0b013e3181d049f0 pmid:20216396
|
74 |
Xu PB, Lin ZY, Meng HB, Yan SK, Yang Y, Liu XR, Li JB, Deng XM, Zhang WD. A metabonomic approach to early prognostic evaluation of experimental sepsis. J Infect 2008; 56(6): 474–481 doi: 10.1016/j.jinf.2008.03.011 pmid:18471887
|
75 |
Izquierdo-García JL, Nin N, Ruíz-Cabello J, Rojas Y, de Paula M, López-Cuenca S, Morales L, Martínez-Caro L, Fernández-Segoviano P, Esteban A, Lorente JA. A metabolomic approach for diagnosis of experimental sepsis. Intensive Care Med 2011; 37(12): 2023–2032 doi: 10.1007/s00134-011-2359-1 pmid:21976186
|
76 |
Lehmann LE, Hunfeld KP, Emrich T, Haberhausen G, Wissing H, Hoeft A, Stüber F. A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol (Berl) 2008; 197(3): 313–324 doi: 10.1007/s00430-007-0063-0 pmid:18008085
|
77 |
Kim J, Gao L, Tan K. Multi-analyte network markers for tumor prognosis. PLoS ONE 2012; 7(12): e52973 doi: 10.1371/journal.pone.0052973 pmid:23300836
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|