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Associations between Mycobacterium tuberculosis Beijing genotype and drug resistance to four first-line drugs: a survey in China |
Haican Liu1, Yuanyuan Zhang1, Zhiguang Liu1, Jinghua Liu1,2, Yolande Hauck1,2, Jiao Liu1,4, Haiyan Dong1, Jie Liu1, Xiuqin Zhao1, Bing Lu1, Yi Jiang1, Gilles Vergnaud2,5, Christine Pourcel2(), Kanglin Wan1,2,3() |
1. State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China 2. University Paris-Sud, Institut de Génétique et Microbiologie, UMR 8621, Orsay, France 3. CNRS, Orsay, France 4. Department of Epidemiology and Health Statistics, Public Health of Central South University, Changsha 421001, China 5. DGA/MRIS-Mission pour la Recherche et l’Innovation Scientifique, Bagneux, France |
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Abstract Investigations on the genetic diversity of Mycobacterium tuberculosis in China have shown that Beijing genotype strains play a dominant role. To study the association between the M.?tuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosis clinical isolates together with epidemiological and clinical information of patients were collected from the center for tuberculosis (TB) prevention and control or TB hospitals in Beijing municipality and nine provinces or autonomous regions in China. Drug resistance testing was conducted on all the isolates to the four first-line anti-TB drugs (isoniazid, rifampicin, streptomycin, and ethambutol). A total of 585 strains were found to be resistant to at least one of the four anti-TB drugs. The Beijing family strains consisted of 499 (53.20%) drug-sensitive strains and 439 (46.80%) drug-resistant strains, whereas the non-Beijing family strains comprised 202 (58.05%) drug-sensitive strains and 146 (41.95%) drug-resistant strains. No significant difference was observed in prevalence (c2=2.41, P>0.05) between the drug-resistant and drug-sensitive strains among the Beijing family strains. Analysis of monoresistance, multidrug-resistant TB, and geographic distribution of drug resistance did not find any relationships between the M.?tuberculosis Beijing genotype and drug-resistance phenotype in China. Results confirmed that the Beijing genotype, the predominant M. tuberculosis genotype in China, was not associated with drug resistance.
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Keywords
tuberculosis
drug resistance
genotype
molecular biology
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Corresponding Author(s):
Christine Pourcel,Kanglin Wan
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Just Accepted Date: 30 November 2017
Online First Date: 05 January 2018
Issue Date: 06 February 2018
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