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Relationship between Th17 cells and allograft
rejection |
Zhikun ZHENG MM,Jinsong LI MD,Ke JIANG MD, |
Department of Thoracic
Surgery, Union Hospital, Tongji Medical College, Huazhong University
of Science and Technology, Wuhan 430022, Hubei Province, China; |
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Abstract Thl7 cells, a special kind of auxiliary type T cells, can secrete IL-17A, IL-17F, IL-21, IL-22, etc., as a newly discovered T-cell subset in recent years. As a different subset from the Thl and Th2 cells, Th17 cells play an important role in the development of a variety of autoimmune diseases. A current study shows that the IL-6 inflammatory response of the organization in combination with the occurrence of TGF-β can induce the differentiation of Thl7 cells. IL-23 can promote the production of IL17, as well as participate in amplification and maintenance of the survival of IL-l7 generating cells. In this process, STAT3 and ROR-γt are key transcription factors for the growing of Thl7 cells. As our knowledge on Th17 family members is rapidly growing and changing, it will be important to specify their involvement in the induction and regulation of allograft rejection in animal models as well as in clinical settings. Herein, we review the key features of Th17 cells and discuss their potential relevance to transplantation immunity.
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Keywords
TH17 cells
regulation
allograft
rejection
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Issue Date: 05 December 2009
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Castellino F, Germain R N. Cooperation between CD4+ and CD8+ T cells: when,where, and how. Annu Rev Immunol, 2006, 24(1): 519–540
doi: 10.1146/annurev.immunol.23.021704.115825
|
|
Park H, Li Z, Yang X O, Chang S H, Nurieva R, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. A distinct lineage of CD4+ T cells regulates tissue inflammation by producinginterleukin 17. Nat Immunol, 2005, 6(11): 1133–1141
doi: 10.1038/ni1261
|
|
Harrington L E, Hatton R D, Mangham P R, Weaver C T. Interleukin 17 producing CD4+ effecterT cells develop via a lineage distinct from the T helper type 1 and2 lineages. Nat Immunol, 2005, 6(11): 1123–1132
doi: 10.1038/ni1254
|
|
Aggarwal S, Ghilardi N, Xie M H, de Sauvagge F J, Gurney A L. Interleukin-23 promotes adistinct CD4+ T cells activation statecharacterized by the production of Interleukin-17. Biol Chem, 2003, 278(3): 1910–1914
doi: 10.1074/jbc.M207577200
|
|
Tato C M, O’Shea J J. What does it mean to be just17? Nature, 2006, 441(11): l66–l68
|
|
Veldhoen M, Hocking R J, Atkins C J, Locksley R M, Stockinger B. TGFbeta in the context ofan inflammatory cytokine milieu supports de novo differentiation ofIL-17-producing T cells. Immunity, 2006, 24(2): l79–189
doi: 10.1016/j.immuni.2006.01.001
|
|
Mangan P R, Harringlon L E, O’Quinn D B. Transforming growth factor-β inducesdevelopment of the TH17 lineage. Nature, 2006, 441: 231–234
doi: 10.1038/nature04754
|
|
Chen Z, Laurence A, Kanno Y, Pacher-Zavisin M, Zhu B M, Tato C, Yoshimura A, Hennighausen L, O’Shea J J. Selective regulatory function of Socs3in the formation of IL-17-secreting T cells. PNAS USA, 2006, 103(21): 8137–1842
doi: 10.1073/pnas.0600666103
|
|
Bettelli E, Carrier Y, Gao W, Korn T, Strom T B, Oukka M, Weiner H L, Kuchroo V K. Reciprocal developmental pathways for the generationof pathogenic effector ThI7 and regulatory T cells. Nature, 2006, 441(7090): 235–238
doi: 10.1038/nature04753
|
|
Langrish C L, Chen Y, Blumenschein W M, Mattson J, Basham B, Sedgwick J D, McClanahan T, Kastelein R A, Cua D J. IL-23 drives a pathogenic T cell population that inducesautoimmune inflammation. J Exp Med, 2005, 201(2): 233–240
doi: 10.1084/jem.20041257
|
|
Yang J, Jia L, Li L, Wu C Y. The differentiationand regulation of Th17 cell. Xibao Yu FenziMianyixue Zazhi, 2008, 24(3): 213–216 (in Chinese)
|
|
Ivanov I I, McKenzie B S, Zhou L, Tadokoro C E, Lepelley A, Lafaille J J, Cua D J, Littman D R. The orphan nuclear receptorRORgammat directs the differentiation program of proinflammatory IL-17+T helper cells. Cell, 2006, 126(6): 1121–1133
doi: 10.1016/j.cell.2006.07.035
|
|
Wahl S M, Wen J, Moutsopoulos N. TGF-beta: a mobile purveyor of immune privilege. Immunol Rev, 2006, 213: 213–217
doi: 10.1111/j.1600-065X.2006.00437.x
|
|
Brender C, Nielsen M, Kaltoft K, Mikkelsen G, Zhang Q, Wasik M, Billestrup N, Odum N. STAT3-mediated constitutiveexpression of SOCS-3 in cutaneous T cell lymphoma. Blood, 2001, 97(4): 1056–1062
doi: 10.1182/blood.V97.4.1056
|
|
Wormald S, Hilton D J. Inhibitors of cytokine signaltransduction. J Biol Chem, 2004, 279(2): 821–824
doi: 10.1074/jbc.R300030200
|
|
Batten M, Li J, Yi S, Kljavin N M, Danilenko D M, Lucas S, Lee J, de Sauvage F J, Ghilardi N. 1nterleukin-27 limits autoimmune encephalomyelitis bysuppressing the development of interleukin-17 producing T cells. Nat lmmunol, 2006, 7(9): 929–936
|
|
Stumhofer J S, Laurence A, Wilson E H, Huang E, Tato C M, Johnson L M, Villarino A V, Huang Q, Yoshimura A, Sehy D, Saris C J, O’Shea J J, Hennighausen L, Ernst M, Hunter C A. Interleukin-27 negatively regulates the development of interleukin-17-producingT helper cells during chronic inflammation of the central nervoussystem. Nat lmmuno1, 2006, 7(9): 937–945
|
|
Niederkorn J Y. Immunology and immunomodulation of corneal transplantation. Int Rev lmmunol, 2002, 21(2,3): 173–196
|
|
Dallman M J. Cytokines and transplantation: Thl/Th2 regulation of the immune responseto solid organ transplants in the adult. Curt Opin Immunol, 1995, 7(5): 632–638
doi: 10.1016/0952-7915(95)80069-7
|
|
Nakae S, Nambu A, Sudo K, Iwakura Y. Suppressionof immune induction of collagen-induced arthritis in IL-17-deficientmice. Immunol, 2003, 171(11): 6173–6177
|
|
Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M, Iwakura Y. Antigen-specificT cell sensitization is impaired in IL-17-deficient mice, causingsuppression of allergic cellular and humoral responses. Immunity, 2002, 17(3): 375–387
doi: 10.1016/S1074-7613(02)00391-6
|
|
Wu C Y. Th17 cell: A new subset of CD4+ T cell. Xibao YuFenziMianyixue Zazhi, 2006, 22(6): 695–697 (in Chinese)
|
|
Loong C C, Hsieh H G, Lui W Y, Chen A, Lin C Y. Evidence for the early involvement ofinterleukin-17 in human and experimental renal allograft rejection. J Pathol, 2002, 197(3): 322–332
doi: 10.1002/path.1117
|
|
Vanaudenaerde B M, Dupont L J, Wuyts W A, Verbeken E K, Meyts I, Bullens D M, Dilissen E, Luyts L, Van Raemdonck D E, Verleden G M. The role of interleukin-17 during acute rejection after lung transplantation. Eur Respir J, 2006, 27(4): 779–787
doi: 10.1183/09031936.06.00019405
|
|
Yoshida S, Haque A, Mizobuchi T, Iwata T, Chiyo M, Webb T J, Baldrige L A, Heidler K M, Cummings O W, Fujisawa T, Blum J S, Brand D D, Wilkers D S. Anti-type V collagen lymphocytesthat express IL-17 and IL-23 induce rejection pathology in fresh andwell-healed lung transplants. Am J Transplant, 2006, 6(4): 724–735
doi: 10.1111/j.1600-6143.2006.01236.x
|
|
Burlingham W J, Love R B, Jankowska-Gan E, Haynes L D, Xu Q, Bobadilla J L, Meyer K C, Hayney M S, Braun R K, Greenspan D S, Gopalakrishnan B, Cai J, Brand D D, Yoshida S, Cummings O W, Wilkes D S. IL-17―dependent cellularimmunity to collagen type V predisposes to obliterative bronchiolitisin human lung transplants. J Clin Invest, 2007, 117(11): 3498–3506
doi: 10.1172/JCI28031
|
|
Hashimoto T, Akiyama K, Kobayashi N, Mori A. Comparisonof IL-17 production by helper T cells among atopic and nonatopic asthmaticsand control subjects. Hat Arch AllergyImmunol, 2005, 137 Suppl 1: 51–54
doi: 10.1159/000085432
|
|
Li J, Simeoni E, Fleury S, Dudler J, Fiorini E, Kappenberger L, Von Segesser L K, Vassalli G. Gene transfer of solubleinterleukin-17 receptor prolongs cardiac allograft survival in a ratmodel. Eur J Cardiothorac Surg, 2006, 29(5): 779–783
doi: 10.1016/j.ejcts.2006.01.052
|
|
Tang J L, Subbotin V M, Antonysamy M A, Troutt A B, Rao A S, Thomson A W. Interleukin-17 antagonism inhibits acute but not chronicvascular rejection. Transplantation, 2001, 72(2): 348–350
doi: 10.1097/00007890-200107270-00035
|
|
Antonysamy M A, Fanslow W C, Fu F, Li W, Qian S, Troutt A B, Thomson A W. Evidence for a role of IL-17in organ allograft rejection: IL-17 promotes the functional differentiationof dendritic cell progenitors. J Immunol, 1999, 162(1): 577–584
|
|
Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D’Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson M R, Iacomini J, Glimcher L H, Sayegh M H, Ansari M J. A novel role of CD4+ Th17cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med, 2008, 205(13): 3133–3144
doi: 10.1084/jem.20081937
|
|
Kapessidon P, Poulin L, Dumoutier L, Goldman M, Renauld J C, Braun M Y. Interleukin-22 deficiency accelerates the rejection offull major histocompatibility complex-disparate heart allografts. Transplant Proc, 2008, 40(5): 1593–1597
doi: 10.1016/j.transproceed.2008.03.151
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