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Molecular mechanisms and therapeutic strategies
of vulnerable atherosclerotic plaques |
Wen-Qiang CHEN MD,Yun ZHANG MD, PhD, FACC, |
The Key Laboratory of
Cardiovascular Remodeling and Function Research, Ministry of Education
and Ministry of Health, Shandong University Qilu Hospital, Jinan 250012,
China; |
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Abstract Vulnerable atherosclerotic plaque rupture leading to thrombosis is the major cause of acute coronary syndrome (ACS). Studies on the pathophysiologic mechanism of both ACS and plaque stabilizing treatment are driving the development of animal models of vulnerable plaque. In our laboratory, we established animal models of plaque rupture and thrombosis in rabbits and mice that are similar to human plaque rupture. Potential mechanisms involved in plaque vulnerability were studied from the inflammation-immunity, proliferation-apoptosis, oxidative stress and biomechanics aspects. Imaging markers and biomarkers were used to detect vulnerable plaques, including high frequency duplex ultrasound, intravascular ultrasound (IVUS), intravascular ultrasound elastography, magnetic resonance imaging (MRI) and inflammatory markers. Effective gene and drug strategies to treat vulnerable plaques were explored.
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Keywords
vulnerable plaque
animal models
mechani-sm
detection
treatment
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Issue Date: 05 March 2010
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