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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med Chin    2010, Vol. 4 Issue (3) : 259-263    https://doi.org/10.1007/s11684-010-0095-5
REVIEW
HPV prevalence and genotyping in the cervix of Chinese women
Shao-Ming WANG, Jing LI, You-Lin QIAO()
Department of Cancer Epidemiology, Cancer Institute of Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
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Abstract

The role of human papillomavirus (HPV) as an etiologic factor of cervical cancer has been firmly established, and prophylactic vaccines are now available and have been approved in many countries. Vaccination implies a promising future for cervical cancer prevention especially for countries with very limited access to screening. However, the vaccines are not accessible in mainland China at the moment, and much needs to be understood about the potential benefit when HPV vaccines are applied to Chinese women, and to make the vaccines more specific to Chinese women. This article reviews advanced multi-center, hospital/population-based studies of most recent years, and aims to draw a definitive conclusion on HPV prevalence and genotyping in cervical cancer and precancerous lesions in China from the aspect of study population, geographic areas and time period.

Keywords human papillomavirus (HPV) genotyping      cervical cancer      precancerous lesions      Chinese women     
Corresponding Author(s): QIAO You-Lin,Email:qiaoy@cicams.ac.cn   
Issue Date: 05 September 2010
 Cite this article:   
Shao-Ming WANG,Jing LI,You-Lin QIAO. HPV prevalence and genotyping in the cervix of Chinese women[J]. Front Med Chin, 2010, 4(3): 259-263.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-010-0095-5
https://academic.hep.com.cn/fmd/EN/Y2010/V4/I3/259
subjectmulti-center studies
authorZhao et al. [6]Dai et al. Wu et al. Li et al. [3-5]Lo et al. [12]Bao et al. [7]Chen et al. [13]
age group (yr)17-5915-59-->18
study year1999-20082004-20051997-1999<20062004-2006
study centerBeijing, Shanghai, Guangzhou, Jiangsu, Shanxi, Jiangxi, Gansu, Henan, XinjiangShanxiShanghai-Zhejiang, Xinjiang, Sichuan, Beijing, Jiangxi, Hunan, Gansu, Chongqing, Nanjing, Guangxi, Shenzhen, Kunming, Zhengzhou, Liaoning, Dalian, Guangzhou, Xi’an
ShenyangGuangzhou
ShenzhenSichuan
Beijing
Hong Kong
study typesummary of 10 cross-sectional studiessummary of three cross-sectional studiesprospective and retrospective multi-center studymeta-analysishospital-based multi-center cross-sectional study
lab assaysHC2 (Qiagen)GP5+/6+ mediated PCRPCR (MY09/11, GP5+/6+)PCR (MY09/11, GP5+/6+, TS–only et al.)SPF10 LiPA25
high risk HPV prevalence
general populationwomen with cervical lesionsgeneral populationwomen with cervical lesions
overall14.51%-15.2%a76.4%a---
normal-----13.10%-
ICC----83.70%82.70%-
SCC-100%----97.60%
ADC------85.30%
CIN1-75.04%-----
CIN2-93.43%----99.30%
CIN3-97.63%----98.80%
HSIL-----88.50%-
LSIL-----69.30%-
HPV type distribution
1-16 (3.7%)a16 (20.3%)a16 (79.6%)16 (61.9%)b16 (76.7%)c
2-58 (2.1%)a58 (12.1%)a18 (7.5%)18 (7.7%)b18 (7.8%)c
3-52 (1.9%)a52 (8.8%)a58 (3.8%)58 (6.4%)b31 (3.2%)c
4-18 (1.1%)a18 (7.1%)a52 (2.6%)52 (3.5%)b52 (2.2%)c
5-39 (1.1%)a56 (4.9%)a31 (3.4%)b58 (2.2%)c
HPV: human papillomavirus; ICC: invasive cervical cancer; SCC: squamous cervical cancer; ADC: adenocarcinoma; CIN: cervical intraepithelial neoplasia; HSIL: high-grade squamous intraepithelial lesion; LSIL: low-grade squamous intraepithelial lesion. a: summary for the multicenter studies; b: HPV type distribution in ICC; c: HPV type distribution in SCC
Tab.1  Summary of multi-center studies on HPV genotyping among Chinese women
regionsSCC (%)CIN3 (%)CIN2 (%)predominant HPV types in SCC
Northeast96.498.490.916, 18, 59, 31, 52
North98.896.7100.016, 18, 31, 58
Northwest98.298.4100.016, 18, 59
Central100100.0100.016, 31, 58, 18, 52, 59
Southwest96.2100.0100.016, 18, 52, 58, 59
South96.7100.0100.016, 18, 52, 58, 59
East97.098.5100.016, 18, 31, 59, 52, 58
total97.698.899.316, 18, 31, 52, 58, 59
Tab.2  Geographic distribution of type specific HPV DNA typing results for ICC, CIN3 and CIN2
1 Zhao F, Li N, Ma J. Study of the association between human papillomavirus infection and cervical cancer in Xianguan county, Shanxi province. Zhonghua Liu Xing Bing Xue Za Zhi , 2001, 22(5): 375-378 (in Chinese)
2 Shen Y H, Chen F, Huang M N, Liu B, Wang X X, Zhao F H, Li S M, Li N, Wu L Y, Rong S D, Zhang W H, Ren S D, Huang R D, Qiao Y L. Population-based study of human papillomavirus infection in high-risk area for cervical cancer in Shanxi Province, China. Zhongguo Yi Xue Ke Xue Yuan Xue Bao , 2003, 25(4): 381-385 (in Chinese)
3 Dai M, Bao Y P, Li N, Clifford G M, Vaccarella S, Snijders P J, Huang R D, Sun L X, Meijer C J, Qiao Y L, Franceschi S. Human papillomavirus infection in Shanxi Province, People’s Republic of China: a population-based study. Br J Cancer , 2006, 95(1): 96-101
doi: 10.1038/sj.bjc.6603208
4 Wu R F, Dai M, Qiao Y L, Clifford G M, Liu Z H, Arslan A, Li N, Shi J F, Snijders P J, Meijer C J, Franceschi S. Human papillomavirus infection in women in Shenzhen City, People’s Republic of China, a population typical of recent Chinese urbanisation. Int J Cancer , 2007, 121(6): 1306-1311
doi: 10.1002/ijc.22726
5 Li L K, Dai M, Clifford G M, Yao W Q, Arslan A, Li N, Shi J F, Snijders P J, Meijer C J, Qiao Y L, Franceschi S. Human papillomavirus infection in Shenyang City, People’s Republic of China: A population-based study. Br J Cancer , 2006, 95(11): 1593-1597
doi: 10.1038/sj.bjc.6603450
6 Zhao F H, Hu S Y, Wang S M, Chen F, Zhang X, Zhang W H, Pan Q J, Qiao Y L. Association between high-risk human papillomavirus DNA load and different histological grades of cervical neoplasia. Zhongguo Yu Fang Yi Xue Zazhi , 2009, 43(7): 565-570 (in Chinese)
7 Bao Y P, Li N, Wang H, Qiao Y L. Study on the distribution of human papillomavirus types in cervix among Chinese women: a meta-analysis. Zhongguo Liu Xing Bing Xue Za Zhi , 2007, 28(10): 941-946 (in Chinese)
8 Stephen A L, Thompson C H, Tattersall M H, Cossart Y E, Rose B R. Analysis of mutations in the URR and E6/E7 oncogenes of HPV 16 cervical cancer isolates from central China. Int J Cancer , 2000, 86(5): 695-701
doi: 10.1002/(SICI)1097-0215(20000601)86:5<695::AID-IJC15>3.0.CO;2-C
9 Wu Y, Chen Y, Li L, Yu G, He Y, Zhang Y. Analysis of mutations in the E6/E7 oncogenes and L1 gene of human papillomavirus 16 cervical cancer isolates from China. J Gen Virol , 2006, 87(Pt 5): 1181-1188
doi: 10.1099/vir.0.81649-0
10 Wu Y, Chen Y, Li L, Yu G, Zhang Y, He Y. Associations of high-risk HPV types and viral load with cervical cancer in China. J Clin Virol , 2006, 35(3): 264-269
doi: 10.1016/j.jcv.2005.07.011
11 Maimaiti A, Mutallip Z, Abliz G, Kurban G. The study of the relationships between HPV subtypes and Xinjiang Uygur and Han with cervical adenocarcinoma. Xinjiang Yi Ke Da Xue Xue Bao , 2009, 32(5): 6 (in Chinese)
12 Lo K W, Wong Y F, Chan M K, Li J C, Poon J S, Wang V W, Zhu S N, Zhang T M, He Z G, Wu Q L, Li G D, Tam J S, Kahn T, Lam P, Cheung T H, Chung T K. Prevalence of human papillomavirus in cervical cancer: a multicenter study in China. Int J Cancer , 2002, 100(3): 327-331
doi: 10.1002/ijc.10506
13 Chen W, Zhang X, Molijn A, Jenkins D, Shi J F, Quint W, Schmidt J E, Wang P, Liu Y L, Li L K, Shi H, Liu J H, Xie X, Niyazi M, Yang P, Wei L H, Li L Y, Li J, Liu J F, Zhou Q, Hong Y, Li L, Li Q, Zhou H L, Bian M L, Chen J, Qiao Y L, Smith J S. Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18. Cancer Causes Control , 2009, 20(9): 1705-1713
doi: 10.1007/s10552-009-9422-z
14 Belinson J L, Hu S, Niyazi M, Pretorius R G, Wang H, Wen C. Prevalence of type-specific human papillomavirus in endocervical, upper and lower vaginal, perineal, and vaginal self-collected specimens; implications for vaginal self-collection. Int J Cancer , 2010, 127(5): 1151-1157
doi: 10.1002/ijc.25144
15 Xie J, Qiao H Z, Wang L, Ma X. Detection of human papillomavirus virus by polymerase chain reaction in cervical cancer in inner Mongolia. Neimenggu Yixue Zazhi , 2005, 37(4): 299-302 (in Chinese)
16 Wu E Q, Zhang G N, Yu X H, Ren Y, Fan Y, Wu Y G, Kong W, Zha X. Evaluation of high-risk human papillomaviruses type distribution in cervical cancer in Sichuan province of China. BMC Cancer , 2008, 8: 202
doi: 10.1186/1471-2407-8-202
17 Zhang W Y, Xue Y Z, Chen M, Han L, Luo M. Prevalence of high-risk human papillomavirus infection in different cervical lesion among organized health-examination women in Shanghai, China. Chin Med J (Engl) , 2008, 121(16): 1578-1582
18 Hong D, Lv W G, Ye F, Chen H Z, Xie X. Detection of human papillomavirus prevalence and HPV genotypes distribution in cervical carcinoma and intraepithelial neoplasia. Xian Dai Fu Chan Ke Jin Zhan , 2006, 15(1): 36-38 (in Chinese)
19 Chan P K, Ho W C, Yu M Y, Pong W M, Chan A C, Chan A K, Cheung T H, Wong M C, To K F, Ng H K. Distribution of human papillomavirus types in cervical cancers in Hong Kong: current situation and changes over the last decades. Int J Cancer , 2009, 125(7): 1671-1677
doi: 10.1002/ijc.24495
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