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Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic urban Chinese population: a cross-section study |
Jie Zheng1,Yuzhen Gao2,Yuejuan Jing3,Xiaoshuang Zhou3,4,Yuanyuan Shi3,4,Yanhong Li3,4,Lihua Wang3,4,Ruiying Wang2,Maolian Li2,Chuanshi Xiao5,Yafeng Li3,4,*(),Rongshan Li4,6,*() |
1. School of Nursing, Shanxi Medical University, Taiyuan 030001 China 2. Department of Cardiology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China 3. Department of Nephrology and Hemodialysis Center, Second Hospital of Shanxi Medical University, Taiyuan 030001, China 4. Shanxi Renal Disease Research Institution, Taiyuan 030001, China 5. Department of Cardiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China 6. Department of Nephrology and Hemodialysis Center, Shanxi Provincial People’s Hospital, Taiyuan 030012, China |
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Abstract The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects (1027 men, and 2433 women, aged 35–75 years old) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376±0.018; middle tertiles, 5.324±0.018; highest tertiles, 5.276±0.018 mmol/L; P=0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75; 95% CI: 1.20--2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.
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Keywords
dyslipidemia
plasma lipids
plasma fasting glucose
impaired fasting glucose
non-diabetes
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Corresponding Author(s):
Yafeng Li
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Online First Date: 15 July 2014
Issue Date: 18 December 2014
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