Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

doi:10.1007/s11684-014-0371-x

Front. Med.

2015, Vol. 9

Issue (1) : 20-29 https://doi.org/10.1007/s11684-014-0371-x

REVIEW

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li¹,Guoheng Hu^2,^*(

),Qilai Cheng¹

1. Post-Graduate School, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
2. Department of Neurology, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, China

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Abstract

Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.

Keywords cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke

Corresponding Author(s): Guoheng Hu

Just Accepted Date: 24 October 2014 Online First Date: 02 February 2015 Issue Date: 02 March 2015

Cite this article:

Yingchen Li,Guoheng Hu,Qilai Cheng. Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges[J]. Front. Med., 2015, 9(1): 20-29.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-014-0371-x
https://academic.hep.com.cn/fmd/EN/Y2015/V9/I1/20

Tab.1 Categories of surface markers expressed by hUC-MSCs

Fig.1 Potential therapeutic mechanisms of hUC-MSCs implantation for ischemic stroke: (1) replacement of damaged nervous cells; (2) promotion of endogenous neural cells; (3) secretion of neurotrophic factors; (4) induction of vascularization and angiogenesis; (5) reduction of apoptosis; (6) prevention of inflammatory effect.

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