|
|
U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population |
Jiangbo Du1,2, Wenjie Xue1, Yong Ji3, Xun Zhu1, Yayun Gu1,2, Meng Zhu1,2, Cheng Wang1,2, Yong Gao4, Juncheng Dai1,2, Hongxia Ma1, Yue Jiang1, Jiaping Chen1,2, Zhibin Hu1,2, Guangfu Jin1,2, Hongbing Shen1,2() |
1. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China 2. Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China 3. Department of Cardiothoracic Surgery, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214043, China 4. Department of Medical Oncology, the Affiliated Huai’an First People’s Hospital of Nanjing Medical University, Huai’an 223300, China |
|
|
Abstract Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma (ESCC) was still uncertain. Several telomere length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study (1045 ESCC cases and 1433 controls) to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length (RTL) (median: 1.34) than controls (median: 1.50, P<0.001). More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk (P<0.001), with odds ratios (95% confidence interval) equal to 2.40 (1.84–3.14), 1.36 (1.03–1.79), 1.01 (0.76–1.35), and 1.37 (1.03–1.82) for individuals in the 1st (the shortest), 2nd, 3rd, and 5th (the longest) quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.
|
Keywords
esophageal squamous cell carcinoma
telomere length
genetic variants
susceptibility
genome-wide association study
|
Corresponding Author(s):
Hongbing Shen
|
Just Accepted Date: 10 October 2015
Online First Date: 17 November 2015
Issue Date: 26 November 2015
|
|
1 |
EH Blackburn. Telomeres and telomerase: the means to the end (Nobel lecture). Angew Chem Int Ed Engl 2010; 49(41): 7405–7421
https://doi.org/10.1002/anie.201002387
pmid: 20821774
|
2 |
RT Calado, NS Young. Telomere diseases. N Engl J Med 2009; 361(24): 2353–2365
https://doi.org/10.1056/NEJMra0903373
pmid: 20007561
|
3 |
X Wu, CI Amos, Y Zhu, H Zhao, BH Grossman, JW Shay, S Luo, WK Hong, MR Spitz. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 2003; 95(16): 1211–1218
https://doi.org/10.1093/jnci/djg011
pmid: 12928346
|
4 |
DT Bau, SM Lippman, E Xu, Y Gong, JJ Lee, X Wu, J Gu. Short telomere lengths in peripheral blood leukocytes are associated with an increased risk of oral premalignant lesion and oral squamous cell carcinoma. Cancer 2013; 119(24): 4277–4283
https://doi.org/10.1002/cncr.28367
pmid: 24105340
|
5 |
JS Jang, YY Choi, WK Lee, JE Choi, SI Cha, YJ Kim, CH Kim, S Kam, TH Jung, JY Park. Telomere length and the risk of lung cancer. Cancer Sci 2008; 99(7): 1385–1389
https://doi.org/10.1111/j.1349-7006.2008.00831.x
pmid: 18452563
|
6 |
HD Hosgood 3rd, R Cawthon, X He, S Chanock, Q Lan. Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. Lung Cancer 2009; 66(2): 157–161
https://doi.org/10.1016/j.lungcan.2009.02.005
pmid: 19285750
|
7 |
Q Lan, R Cawthon, Y Gao, W Hu, HD Hosgood 3rd, F Barone-Adesi, BT Ji, B Bassig, WH Chow, X Shu, Q Cai, Y Xiang, S Berndt, C Kim, S Chanock, W Zheng, N Rothman. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS ONE 2013; 8(3): e59230
https://doi.org/10.1371/journal.pone.0059230
pmid: 23555636
|
8 |
L Shao, CG Wood, D Zhang, NM Tannir, S Matin, CP Dinney, X Wu. Telomere dysfunction in peripheral lymphocytes as a potential predisposition factor for renal cancer. J Urol 2007; 178(4 Pt 1): 1492–1496
https://doi.org/10.1016/j.juro.2007.05.112
pmid: 17707063
|
9 |
K Broberg, J Björk, K Paulsson, M Höglund, M Albin. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis 2005; 26(7): 1263–1271
https://doi.org/10.1093/carcin/bgi063
pmid: 15746160
|
10 |
M McGrath, JY Wong, D Michaud, DJ Hunter, I De Vivo. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev 2007; 16(4): 815–819
https://doi.org/10.1158/1055-9965.EPI-06-0961
pmid: 17416776
|
11 |
L Mirabello, M Garcia-Closas, R Cawthon, J Lissowska, LA Brinton, B Pepłońska, ME Sherman, SA Savage. Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study. Cancer Causes Control 2010; 21(1): 77–82
https://doi.org/10.1007/s10552-009-9436-6
pmid: 19784860
|
12 |
KA Pooley, MS Sandhu, J Tyrer, M Shah, KE Driver, RN Luben, SA Bingham, BA Ponder, PD Pharoah, KT Khaw, DF Easton, AM Dunning. Telomere length in prospective and retrospective cancer case-control studies. Cancer Res 2010; 70(8): 3170–3176
https://doi.org/10.1158/0008-5472.CAN-09-4595
pmid: 20395204
|
13 |
J Shen, MD Gammon, MB Terry, Q Wang, P Bradshaw, SL Teitelbaum, AI Neugut, RM Santella. Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer 2009; 124(7): 1637–1643
https://doi.org/10.1002/ijc.24105
pmid: 19089916
|
14 |
J Shen, MB Terry, I Gurvich, Y Liao, RT Senie, RM Santella. Short telomere length and breast cancer risk: a study in sister sets. Cancer Res 2007; 67(11): 5538–5544
https://doi.org/10.1158/0008-5472.CAN-06-3490
pmid: 17545637
|
15 |
J Han, AA Qureshi, J Prescott, Q Guo, L Ye, DJ Hunter, I De Vivo. A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol 2009; 129(2): 415–421
https://doi.org/10.1038/jid.2008.238
pmid: 18668136
|
16 |
U Svenson, K Nordfjäll, B Stegmayr, J Manjer, P Nilsson, B Tavelin, R Henriksson, P Lenner, G Roos. Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Res 2008; 68(10): 3618–3623
https://doi.org/10.1158/0008-5472.CAN-07-6497
pmid: 18483243
|
17 |
MM Gramatges, ML Telli, R Balise, JM Ford. Longer relative telomere length in blood from women with sporadic and familial breast cancer compared with healthy controls. Cancer Epidemiol Biomarkers Prev 2010; 19(2): 605–613
https://doi.org/10.1158/1055-9965.EPI-09-0896
pmid: 20142254
|
18 |
I De Vivo, J Prescott, JY Wong, P Kraft, SE Hankinson, DJ Hunter. A prospective study of relative telomere length and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 2009; 18(4): 1152–1156
https://doi.org/10.1158/1055-9965.EPI-08-0998
pmid: 19293310
|
19 |
M Shen, R Cawthon, N Rothman, SJ Weinstein, J Virtamo, HD Hosgood 3rd, W Hu, U Lim, D Albanes, Q Lan. A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer. Lung Cancer 2011; 73(2): 133–137
https://doi.org/10.1016/j.lungcan.2010.11.009
pmid: 21507503
|
20 |
B Sanchez-Espiridion, M Chen, JY Chang, C Lu, DW Chang, JA Roth, X Wu, J Gu. Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians. Cancer Res 2014; 74(9): 2476–2486
https://doi.org/10.1158/0008-5472.CAN-13-2968
pmid: 24618342
|
21 |
J Liu, Y Yang, H Zhang, S Zhao, H Liu, N Ge, H Yang, JL Xing, Z Chen. Longer leukocyte telomere length predicts increased risk of hepatitis B virus-related hepatocellular carcinoma: a case-control analysis. Cancer 2011; 117(18): 4247–4256
https://doi.org/10.1002/cncr.26015
pmid: 21387275
|
22 |
Q Lan, R Cawthon, M Shen, SJ Weinstein, J Virtamo, U Lim, HD Hosgood 3rd, D Albanes, N Rothman. A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin Cancer Res 2009; 15(23): 7429–7433
https://doi.org/10.1158/1078-0432.CCR-09-0845
pmid: 19934287
|
23 |
HG Skinner, RE Gangnon, K Litzelman, RA Johnson, ST Chari, GM Petersen, LA Boardman. Telomere length and pancreatic cancer: a case-control study. Cancer Epidemiol Biomarkers Prev 2012; 21(11): 2095–2100
https://doi.org/10.1158/1055-9965.EPI-12-0671
pmid: 23093543
|
24 |
S Qu, W Wen, XO Shu, WH Chow, YB Xiang, J Wu, BT Ji, N Rothman, G Yang, Q Cai, YT Gao, W Zheng. Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women’s Health Study. Am J Epidemiol 2013; 177(7): 617–624
https://doi.org/10.1093/aje/kws291
pmid: 23444102
|
25 |
S Wang, Y Chen, F Qu, S He, X Huang, H Jiang, T Jin, S Wan, J Xing. Association between leukocyte telomere length and glioma risk: a case-control study. Neuro-oncol 2014; 16(4): 505–512
https://doi.org/10.1093/neuonc/not240
pmid: 24366909
|
26 |
J Du, X Zhu, C Xie, N Dai, Y Gu, M Zhu, C Wang, Y Gao, F Pan, C Ren, Y Ji, J Dai, H Ma, Y Jiang, J Chen, H Yi, Y Zhao, Z Hu, H Shen, G Jin. Telomere length, genetic variants and gastric cancer risk in a Chinese population. Carcinogenesis, 2015; 36(9): 963–970
https://doi.org/10.1093/carcin/bgv075
pmid: 26025910
|
27 |
PE Slagboom, S Droog, DI Boomsma. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 1994; 55(5): 876–882
pmid: 7977349
|
28 |
V Codd, CP Nelson, E Albrecht, M Mangino, J Deelen, JL Buxton, JJ Hottenga, K Fischer, T Esko, I Surakka, L Broer, DR Nyholt, I Mateo Leach, P Salo, S Hägg, MK Matthews, J Palmen, GD Norata, PF O’Reilly, D Saleheen, N Amin, AJ Balmforth, M Beekman, RA de Boer, S Böhringer, PS Braund, PR Burton, AJ de Craen, M Denniff, Y Dong, K Douroudis, E Dubinina, JG Eriksson, K Garlaschelli, D Guo, AL Hartikainen, AK Henders, JJ Houwing-Duistermaat, L Kananen, LC Karssen, J Kettunen, N Klopp, V Lagou, EM van Leeuwen, PA Madden, R Mägi, PK Magnusson, S Männistö, MI McCarthy, SE Medland, E Mihailov, GW Montgomery, BA Oostra, A Palotie, A Peters, H Pollard, A Pouta, I Prokopenko, S Ripatti, V Salomaa, HE Suchiman, AM Valdes, N Verweij, A Viñuela, X Wang, HE Wichmann, E Widen, G Willemsen, MJ Wright, K Xia, X Xiao, DJ van Veldhuisen, AL Catapano, MD Tobin, AS Hall, AI Blakemore, WH van Gilst, H Zhu, C Consortium, J Erdmann, MP Reilly, S Kathiresan, H Schunkert, PJ Talmud, NL Pedersen, M Perola, W Ouwehand, J Kaprio, NG Martin, CM van Duijn, I Hovatta, C Gieger, A Metspalu, DI Boomsma, MR Jarvelin, PE Slagboom, JR Thompson, TD Spector, P van der Harst, NJ Samani. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 2013; 45(4): 422–427, e1−e2
https://doi.org/10.1038/ng.2528
pmid: 23535734
|
29 |
V Codd, M Mangino, P van der Harst, PS Braund, M Kaiser, AJ Beveridge, S Rafelt, J Moore, C Nelson, N Soranzo, G Zhai, AM Valdes, H Blackburn, I Mateo Leach, RA de Boer, M Kimura, A; Wellcome Trust Case Control Consortium, Aviv AH Goodall, W Ouwehand, DJ van Veldhuisen, WH van Gilst, G Navis, PR Burton, MD Tobin, AS Hall, JR Thompson, T Spector, NJ Samani. Common variants near TERC are associated with mean telomere length. Nat Genet 2010; 42(3): 197–199
https://doi.org/10.1038/ng.532
pmid: 20139977
|
30 |
D Levy, SL Neuhausen, SC Hunt, M Kimura, SJ Hwang, W Chen, JC Bis, AL Fitzpatrick, E Smith, AD Johnson, JP Gardner, SR Srinivasan, N Schork, JI Rotter, U Herbig, BM Psaty, M Sastrasinh, SS Murray, RS Vasan, MA Province, NL Glazer, X Lu, X Cao, R Kronmal, M Mangino, N Soranzo, TD Spector, GS Berenson, A Aviv. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci USA 2010; 107(20): 9293–9298
https://doi.org/10.1073/pnas.0911494107
pmid: 20421499
|
31 |
SE Bojesen, KA Pooley, SE Johnatty, J Beesley, K Michailidou, JP Tyrer, SL Edwards, HA Pickett, HC Shen, CE Smart, KM Hillman, PL Mai, K Lawrenson, MD Stutz, Y Lu, R Karevan, N Woods, RL Johnston, JD French, X Chen, M Weischer, SF Nielsen, MJ Maranian, M Ghoussaini, S Ahmed, C Baynes, MK Bolla, Q Wang, J Dennis, L McGuffog, D Barrowdale, A Lee, S Healey, M Lush, DC Tessier, D Vincent, F Bacot; Australian Cancer Study; Australian Ovarian Cancer Study; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab); Gene Environment Interaction and Breast Cancer (GENICA); Swedish Breast Cancer Study (SWE-BRCA); Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE); Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO), I Vergote, S Lambrechts, E Despierre, HA Risch, A González-Neira, MA Rossing, G Pita, JA Doherty, N Alvarez, MC Larson, BL Fridley, N Schoof, J Chang-Claude, MS Cicek, J Peto, KR Kalli, A Broeks, SM Armasu, MK Schmidt, LM Braaf, B Winterhoff, H Nevanlinna, GE Konecny, D Lambrechts, L Rogmann, P Guénel, A Teoman, RL Milne, JJ Garcia, A Cox, V Shridhar, B Burwinkel, F Marme, R Hein, EJ Sawyer, CA Haiman, S Wang-Gohrke, IL Andrulis, KB Moysich, JL Hopper, K Odunsi, A Lindblom, GG Giles, H Brenner, J Simard, G Lurie, PA Fasching, ME Carney, P Radice, LR Wilkens, A Swerdlow, MT Goodman, H Brauch, M Garcia-Closas, P Hillemanns, R Winqvist, M Dürst, P Devilee, I Runnebaum, A Jakubowska, J Lubinski, A Mannermaa, R Butzow, NV Bogdanova, T Dörk, LM Pelttari, W Zheng, A Leminen, H Anton-Culver, CH Bunker, V Kristensen, RB Ness, K Muir, R Edwards, A Meindl, F Heitz, K Matsuo, A du Bois, AH Wu, P Harter, SH Teo, I Schwaab, XO Shu, W Blot, S Hosono, D Kang, T Nakanishi, M Hartman, Y Yatabe, U Hamann, BY Karlan, S Sangrajrang, SK Kjaer, V Gaborieau, A Jensen, D Eccles, E Høgdall, CY Shen, J Brown, YL Woo, M Shah, MA Azmi, R Luben, SZ Omar, K Czene, RA Vierkant, BG Nordestgaard, H Flyger, C Vachon, JE Olson, X Wang, DA Levine, A Rudolph, RP Weber, D Flesch-Janys, E Iversen, S Nickels, JM Schildkraut, IS Silva, DW Cramer, L Gibson, KL Terry, O Fletcher, AF Vitonis, CE van der Schoot, EM Poole, FB Hogervorst, SS Tworoger, J Liu, EV Bandera, J Li, SH Olson, K Humphreys, I Orlow, C Blomqvist, L Rodriguez-Rodriguez, K Aittomäki, HB Salvesen, TA Muranen, E Wik, B Brouwers, C Krakstad, E Wauters, MK Halle, H Wildiers, LA Kiemeney, C Mulot, KK Aben, P Laurent-Puig, AM Altena, T Truong, LF Massuger, J Benitez, T Pejovic, JI Perez, M Hoatlin, MP Zamora, LS Cook, SP Balasubramanian, LE Kelemen, A Schneeweiss, ND Le, C Sohn, A Brooks-Wilson, I Tomlinson, MJ Kerin, N Miller, C Cybulski, BE Henderson, J Menkiszak, F Schumacher, N Wentzensen, L Le Marchand, HP Yang, AM Mulligan, G Glendon, SA Engelholm, JA Knight, CK Høgdall, C Apicella, M Gore, H Tsimiklis, H Song, MC Southey, A Jager, AM den Ouweland, R Brown, JW Martens, JM Flanagan, M Kriege, J Paul, S Margolin, N Siddiqui, G Severi, AS Whittemore, L Baglietto, V McGuire, C Stegmaier, W Sieh, H Müller, V Arndt, F Labrèche, YT Gao, MS Goldberg, G Yang, M Dumont, JR McLaughlin, A Hartmann, AB Ekici, MW Beckmann, CM Phelan, MP Lux, J Permuth-Wey, B Peissel, TA Sellers, F Ficarazzi, M Barile, A Ziogas, A Ashworth, A Gentry-Maharaj, M Jones, SJ Ramus, N Orr, U Menon, CL Pearce, T Brüning, MC Pike, YD Ko, J Lissowska, J Figueroa, J Kupryjanczyk, SJ Chanock, A Dansonka-Mieszkowska, A Jukkola-Vuorinen, IK Rzepecka, K Pylkäs, M Bidzinski, S Kauppila, A Hollestelle, C Seynaeve, RA Tollenaar, K Durda, K Jaworska, JM Hartikainen, VM Kosma, V Kataja, NN Antonenkova, J Long, M Shrubsole, S Deming-Halverson, A Lophatananon, P Siriwanarangsan, S Stewart-Brown, N Ditsch, P Lichtner, RK Schmutzler, H Ito, H Iwata, K Tajima, CC Tseng, DO Stram, D van den Berg, CH Yip, MK Ikram, YC Teh, H Cai, W Lu, LB Signorello, Q Cai, DY Noh, KY Yoo, H Miao, PT Iau, YY Teo, J McKay, C Shapiro, F Ademuyiwa, G Fountzilas, CN Hsiung, JC Yu, MF Hou, CS Healey, C Luccarini, S Peock, D Stoppa-Lyonnet, P Peterlongo, TR Rebbeck, M Piedmonte, CF Singer, E Friedman, M Thomassen, K Offit, TV Hansen, SL Neuhausen, CI Szabo, I Blanco, J Garber, SA Narod, JN Weitzel, M Montagna, E Olah, AK Godwin, D Yannoukakos, DE Goldgar, T Caldes, EN Imyanitov, L Tihomirova, BK Arun, I Campbell, AR Mensenkamp, CJ van Asperen, KE van Roozendaal, H Meijers-Heijboer, JM Collée, JC Oosterwijk, MJ Hooning, MA Rookus, RB van der Luijt, TA Os, DG Evans, D Frost, E Fineberg, J Barwell, L Walker, MJ Kennedy, R Platte, R Davidson, SD Ellis, T Cole, B Bressac-de Paillerets, B Buecher, F Damiola, L Faivre, M Frenay, OM Sinilnikova, O Caron, S Giraud, S Mazoyer, V Bonadona, V Caux-Moncoutier, A Toloczko-Grabarek, J Gronwald, T Byrski, AB Spurdle, B Bonanni, D Zaffaroni, G Giannini, L Bernard, R Dolcetti, S Manoukian, N Arnold, C Engel, H Deissler, K Rhiem, D Niederacher, H Plendl, C Sutter, B Wappenschmidt, A Borg, B Melin, J Rantala, M Soller, KL Nathanson, SM Domchek, GC Rodriguez, R Salani, DG Kaulich, MK Tea, SS Paluch, Y Laitman, AB Skytte, TA Kruse, UB Jensen, M Robson, AM Gerdes, B Ejlertsen, L Foretova, SA Savage, J Lester, P Soucy, KB Kuchenbaecker, C Olswold, JM Cunningham, S Slager, VS Pankratz, E Dicks, SR Lakhani, FJ Couch, P Hall, AN Monteiro, SA Gayther, PD Pharoah, RR Reddel, EL Goode, MH Greene, DF Easton, A Berchuck, AC Antoniou, G Chenevix-Trench, AM Dunning. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet 2013; 45(4): 371–384, e1−e2
https://doi.org/10.1038/ng.2566
pmid: 23535731
|
32 |
JD McKay, RJ Hung, V Gaborieau, P Boffetta, A Chabrier, G Byrnes, D Zaridze, A Mukeria, N Szeszenia-Dabrowska, J Lissowska, P Rudnai, E Fabianova, D Mates, V Bencko, L Foretova, V Janout, J McLaughlin, F Shepherd, A Montpetit, S Narod, HE Krokan, F Skorpen, MB Elvestad, L Vatten, I Njølstad, T Axelsson, C Chen, G Goodman, M Barnett, MM Loomis, J Lubiñski, J Matyjasik, M Lener, D Oszutowska, J Field, T Liloglou, G Xinarianos, A Cassidy; EPIC Study, P Vineis, F Clavel-Chapelon, D Palli, R Tumino, V Krogh, S Panico, CA González, J Ramón Quirós, C Martínez, C Navarro, E Ardanaz, N Larrañaga, KT Kham, T Key, HB Bueno-de-Mesquita, PH Peeters, A Trichopoulou, J Linseisen, H Boeing, G Hallmans, K Overvad, A Tjønneland, M Kumle, E Riboli, D Zelenika, A Boland, M Delepine, M Foglio, D Lechner, F Matsuda, H Blanche, I Gut, S Heath, M Lathrop, P Brennan. Lung cancer susceptibility locus at 5p15.33. Nat Genet 2008; 40(12): 1404–1406
https://doi.org/10.1038/ng.254
pmid: 18978790
|
33 |
Z Hu, C Wu, Y Shi, H Guo, X Zhao, Z Yin, L Yang, J Dai, L Hu, W Tan, Z Li, Q Deng, J Wang, W Wu, G Jin, Y Jiang, D Yu, G Zhou, H Chen, P Guan, Y Chen, Y Shu, L Xu, X Liu, L Liu, P Xu, B Han, C Bai, Y Zhao, H Zhang, Y Yan, H Ma, J Chen, M Chu, F Lu, Z Zhang, F Chen, X Wang, L Jin, J Lu, B Zhou, D Lu, T Wu, D Lin, H Shen. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet 2011; 43(8): 792–796
https://doi.org/10.1038/ng.875
pmid: 21725308
|
34 |
AM Jones, AD Beggs, L Carvajal-Carmona, S Farrington, A Tenesa, M Walker, K Howarth, S Ballereau, SV Hodgson, A Zauber, M Bertagnolli, R Midgley, H Campbell, D Kerr, MG Dunlop, IP Tomlinson. TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut 2012; 61(2): 248–254
https://doi.org/10.1136/gut.2011.239772
pmid: 21708826
|
35 |
J Ferlay, I Soerjomataram, M Ervik, R Dikshit, S Eser, C Mathers, M Rebelo, DM Parkin, D Forman, F Bray. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer.
|
36 |
Q Yu, J Yang, B Liu, W Li, G Hu, H Qiu, L Huang, H Xiong, X Yuan. Combined effects of leukocyte telomere length, p53 polymorphism and human papillomavirus infection on esophageal squamous cell carcinoma in a Han Chinese population. Cancer Epidemiol 2014; 38(5): 569–575
https://doi.org/10.1016/j.canep.2014.07.010
pmid: 25153662
|
37 |
J Shi, F Sun, L Peng, B Li, L Liu, C Zhou, J Han, L Zhang, L Zhou, X Zhang, H Pu, L Tong, Q Yuan, X Song, M Yang. Leukocyte telomere length-related genetic variants in 1p34.2 and 14q21 loci contribute to the risk of esophageal squamous cell carcinoma. Int J Cancer 2013; 132(12): 2799–2807
https://doi.org/10.1002/ijc.27959
pmid: 23180556
|
38 |
M Weischer, BG Nordestgaard, RM Cawthon, JJ Freiberg, A Tybjærg-Hansen, SE Bojesen. Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst 2013; 105(7): 459–468
https://doi.org/10.1093/jnci/djt016
pmid: 23468462
|
39 |
RM Cawthon. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002; 30(10): e47
https://doi.org/10.1093/nar/30.10.e47
pmid: 12000852
|
40 |
L Desquilbet, F Mariotti. Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 2010; 29(9): 1037–1057
pmid: 20087875
|
41 |
AJ Cesare, RR Reddel. Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet 2010; 11(5): 319–330
https://doi.org/10.1038/nrg2763
pmid: 20351727
|
42 |
T Rafnar, P Sulem, SN Stacey, F Geller, J Gudmundsson, A Sigurdsson, M Jakobsdottir, H Helgadottir, S Thorlacius, KK Aben, T Blöndal, TE Thorgeirsson, G Thorleifsson, K Kristjansson, K Thorisdottir, R Ragnarsson, B Sigurgeirsson, H Skuladottir, T Gudbjartsson, HJ Isaksson, GV Einarsson, KR Benediktsdottir, BA Agnarsson, K Olafsson, A Salvarsdottir, H Bjarnason, M Asgeirsdottir, KT Kristinsson, S Matthiasdottir, SG Sveinsdottir, S Polidoro, V Höiom, R Botella-Estrada, K Hemminki, P Rudnai, DT Bishop, M Campagna, E Kellen, MP Zeegers, P de Verdier, A Ferrer, D Isla, MJ Vidal, R Andres, B Saez, P Juberias, J Banzo, S Navarrete, A Tres, D Kan, A Lindblom, E Gurzau, K Koppova, F de Vegt, JA Schalken, HF van der Heijden, HJ Smit, RA Termeer, E Oosterwijk, O van Hooij, E Nagore, S Porru, G Steineck, J Hansson, F Buntinx, WJ Catalona, G Matullo, P Vineis, AE Kiltie, JI Mayordomo, R Kumar, LA Kiemeney, ML Frigge, T Jonsson, H Saemundsson, RB Barkardottir, E Jonsson, S Jonsson, JH Olafsson, JR Gulcher, G Masson, DF Gudbjartsson, A Kong, U Thorsteinsdottir, K Stefansson. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet 2009; 41(2): 221–227
https://doi.org/10.1038/ng.296
pmid: 19151717
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|