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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

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Front. Med.    2015, Vol. 9 Issue (3) : 374-379    https://doi.org/10.1007/s11684-015-0411-1
RESEARCH ARTICLE
Factors related to compliance with oral analgesic treatment of inpatients with chronic pain
Hong Zhu1,Yuzhu Zheng2,Hui Gao3,Li Liu4,Lie Yang5,*()
1. Department of Nursing Quality Control, West China Hospital, Sichuan University, Chengdu 610041, China
2. Department of Oncology, The Third People’s Hospital of Chengdu, Chengdu 610041, China
3. West China School of Medicine, Sichuan University, Chengdu 610041, China
4. Department of Pain Ward, West China Hospital, Sichuan University, Chengdu 610041, China
5. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
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Abstract

This study aimed to determine the relationship between the different factors of analgesic therapy and the compliance of chronic pain inpatients. We prospectively investigated 100 consecutive inpatients with non-cancer chronic pain who were hospitalized to receive oral analgesic treatment in the Pain Department of West China Hospital from May 2013 to October 2013. Patients who completed the treatment plan were recorded as good compliance, whereas patients who partly completed or even refused the treatment were recorded as moderate or non-compliance, respectively. A total of 73 (73.7%), 17 (17.1%), and 9 (9.2%) patients showed good, moderate, and non-compliance, respectively. Univariate analyses showed significantly better compliance among farmers, patients educated in college or above, with family income of<3000 CNY, and with severe or moderate pain than those employed and unemployed (P=0.02), patients educated below college (P=0.013), with family income of≥3000 CNY (P=0.025), and with mild pain (P<0.001), respectively. Logistic regression analysis showed that the family income of≥3000 CNY (OR: 2.50, 95%CI: 1.65–4.51, P=0.021) and mild pain (OR: 1.27, 95%CI: 1.03–3.31, P=0.016) were associated with moderate or non-compliance with oral analgesic treatment. In conclusion, the low compliance with oral treatment of analgesics was found in Chinese inpatients with chronic pain and compliance was negatively associated with family income and degree of pain of patients.
Keywords chronic pain      inpatient      oral paregoric drugs      compliance     
Corresponding Author(s): Lie Yang   
Just Accepted Date: 28 July 2015   Online First Date: 20 August 2015    Issue Date: 26 August 2015
 Cite this article:   
Hong Zhu,Yuzhu Zheng,Hui Gao, et al. Factors related to compliance with oral analgesic treatment of inpatients with chronic pain[J]. Front. Med., 2015, 9(3): 374-379.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-015-0411-1
https://academic.hep.com.cn/fmd/EN/Y2015/V9/I3/374
Variables n %
Gender
Male 43 43.4
Female 56 56.6
Age (year)
<60 49 49.5
≥60 50 50.5
Pain site
Limb or trunk pain 25 25.2
Herpes zoster neuralgia 36 36.4
Osteoporosis 18 18.2
Others 20 20.2
Type of analgesics
Non-opioid 45 45.5
Opioid 54 54.5
Pain by VAS scale (score)
Mild (≤5) 32 32.3
Moderate (5-8) 30 30.3
Severe (≥8) 37 37.4
Occupation
Farmer 35 35.4
Employed 35 35.4
Unemployed 29 29.3
Education
High school or below 53 53.5
College or above 46 46.5
Family income (CNY/month)
<3000 50 50.5
≥3000 49 49.5
Tab.1  Baseline characteristics of total sample (n = 99)
Anxiety by SAS scale (score) n %
Normal (20-44) 58 58.6
Anxiety (≥45) 41 41.4
Mild (45-59) 21
Moderate (60-74) 11
Severe (75-80) 9
Depression by SDS scale (score)
Normal (20-44) 81 81.8
Depression (≥45) 18 18.2
Mild (45-59) 8
Moderate (60-69) 5
Severe (≥70) 5
Tab.2  Anxiety and depression states of patients
Variables Total number (n) Compliance with oral analgesic treatment P value
Good n (%) Moderate+poor n (%)
Gender 0.83
Male 43 32 (74.4) 11 (25.6)
Female 56 41 (73.2) 15 (27.8)
Age (year) 0.52
<60 49 39 (79.6) 10 (20.4)
≥60 50 34 (68.0) 16 (32.0)
Pain site 0.26
Limb or trunk pain 25 19 (76.0) 6 (24.0)
Herpes zoster neuralgia 36 27 (75.0) 9 (25.0)
Osteoporosis 18 14 (77.8) 4 (22.2)
Others 20 13 (56.0) 7 (44.0)
Type of Analgesics
Non-opioid 45 36 (80.0) 9 (20.0)
Opioid 54 37 (50.7) 17 (49.3)
Pain by VAS scale (score) <0.001
Mild (≤5) 32 13 (40.6) 19 (59.4)
Moderate (5-8) 30 28 (93.3) 2 (6.7)
Severe (≥8) 37 32 (84.5) 5 (15.5)
Occupation 0.02
Farmer 35 31 (88.6) 5 (11.4)
Employed 35 25 (71.4) 10 (28.6)
Unemployed 29 17 (58.6) 12 (41.4)
Education 0.013
High school or below 53 34 (61.2) 19 (38.8)
College or above 46 39 (84.8) 7 (15.2)
Family income (CNY/month) 0.025
<3000 50 45 (90.0) 5 (10.0)
≥3000 49 28 (57.1) 21 (42.9)
Anxiety by SAS scale (score) 0.18
Normal (20-44) 58 45 (77.5) 13 (22.5)
Anxiety (≥45) 41 28 (68.3) 13 (31.7)
Depression by SDS scale (score) 0.15
Normal (20-44) 81 58 (71.6) 23 (28.4)
Depression (≥45) 18 15 (83.3) 3 (16.7)
Tab.3  Patient compliance with oral analgesic treatment by univariate analysis
Variables OR (95% CI) P value
Education (Middle school or below) versus (college or above) 1.64 (1.02-2.83) 0.09
Family income >3000 versus≤3000 2.50 (1.65-4.51) <0.001
Pain by VAS scale Mild versus (moderate or severe) 1.27 (1.03-3.31) 0.016
Depression by SDS scale No versus Yes 1.02 (0.76-2.65) 0.52
Tab.4  Multivariate model of compliance for patients with chronic pain
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[1] ZHANG Li, MI Jie, LI Ming, JIANG Benyu. Association of metabolic syndrome with arterial compliance in children and adolescents[J]. Front. Med., 2007, 1(1): 68-73.
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