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Hybrid polymer biomaterials for bone tissue regeneration |
Bo Lei1, Baolin Guo1, Kunal J. Rambhia2, Peter X. Ma1,2,3,4,5() |
1. Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China 2. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA 3. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA 4. Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA 5. Department of Material Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA |
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Abstract Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the extracellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further exemplifies their applications for bone tissue regeneration.
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Keywords
hybrid polymer
bone regeneration
tissue engineering
biomaterials
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Corresponding Author(s):
Peter X. Ma
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Just Accepted Date: 04 September 2018
Online First Date: 31 October 2018
Issue Date: 28 March 2019
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|
1 |
FMWatt, WTS Huck. Role of the extracellular matrix in regulating stem cell fate. Nat Rev Mol Cell Biol 2013; 14(8): 467–473
https://doi.org/10.1038/nrm3620
pmid: 23839578
|
2 |
IEErickson, SR Kestle, KHZellars, MJFarrell, MKim, JA Burdick, RLMauck. High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties. Acta Biomater 2012; 8(8): 3027–3034
https://doi.org/10.1016/j.actbio.2012.04.033
pmid: 22546516
|
3 |
SSLee, BJ Huang, SRKaltz, SSur, CJ Newcomb, SRStock, RNShah, SIStupp. Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds. Biomaterials 2013; 34(2): 452–459
https://doi.org/10.1016/j.biomaterials.2012.10.005
pmid: 23099062
|
4 |
SVDorozhkin. Calcium orthophosphate-containing biocomposites and hybrid biomaterials for biomedical applications. J Funct Biomater 2015; 6(3): 708–832
https://doi.org/10.3390/jfb6030708
pmid: 26262645
|
5 |
WWu, WG Wang, JSLi. Star polymers: advances in biomedical applications. Prog Polym Sci 2015; 46: 55–85
https://doi.org/10.1016/j.progpolymsci.2015.02.002
|
6 |
JNicolas, S Mura, DBrambilla, NMackiewicz, PCouvreur. Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery. Chem Soc Rev 2013; 42(3): 1147–1235
https://doi.org/10.1039/C2CS35265F
pmid: 23238558
|
7 |
HYTian, ZH Tang, XLZhuang, XSChen, XBJing. Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Prog Polym Sci 2012; 37(2): 237–280
https://doi.org/10.1016/j.progpolymsci.2011.06.004
|
8 |
ZPan, J Ding. Poly(lactide-co-glycolide) porous scaffolds for tissue engineering and regenerative medicine. Interface Focus 2012; 2(3): 366–377
https://doi.org/10.1098/rsfs.2011.0123
pmid: 23741612
|
9 |
JCIgwe, PE Mikael, SPNukavarapu. Design, fabrication and in vitro evaluation of a novel polymer-hydrogel hybrid scaffold for bone tissue engineering. J Tissue Eng Regen Med 2014; 8(2): 131–142
https://doi.org/10.1002/term.1506
pmid: 22689304
|
10 |
JVenkatesan, I Bhatnagar, PManivasagan, KHKang, SKKim. Alginate composites for bone tissue engineering: a review. Int J Biol Macromol 2015; 72: 269–281
https://doi.org/10.1016/j.ijbiomac.2014.07.008
pmid: 25020082
|
11 |
JVenkatesan, PA Vinodhini, PNSudha, SKKim. Chitin and chitosan composites for bone tissue regeneration. Adv Food Nutr Res 2014;73: 59–81 PMID: 25300543
https://doi.org/10.1016/B978-0-12-800268-1.00005-6
|
12 |
RYunus Basha, TSSampath Kumar, MDoble. Design of biocomposite materials for bone tissue regeneration. Mater Sci Eng C 2015; 57: 452–463
https://doi.org/10.1016/j.msec.2015.07.016
pmid: 26354284
|
13 |
FSun, H Zhou, JLee. Various preparation methods of highly porous hydroxyapatite/polymer nanoscale biocomposites for bone regeneration. Acta Biomater 2011; 7(11): 3813–3828
https://doi.org/10.1016/j.actbio.2011.07.002
pmid: 21784182
|
14 |
KGkioni, SCG Leeuwenburgh, TELDouglas, AGMikos, JAJansen. Mineralization of hydrogels for bone regeneration. Tissue Eng Part B Rev 2010; 16(6): 577–585
https://doi.org/10.1089/ten.teb.2010.0462
pmid: 20735319
|
15 |
QWei, J Lu, QWang, HFan, X Zhang. Novel synthesis strategy for composite hydrogel of collagen/hydroxyapatite-microsphere originating from conversion of CaCO3 templates. Nanotechnology 2015; 26(11): 115605
https://doi.org/10.1088/0957-4484/26/11/115605
pmid: 25719911
|
16 |
TNVo, SR Shah, SLu, AMTatara, EJLee, TT Roh, YTabata, AGMikos. Injectable dual-gelling cell-laden composite hydrogels for bone tissue engineering. Biomaterials 2016; 83: 1–11
https://doi.org/10.1016/j.biomaterials.2015.12.026
pmid: 26773659
|
17 |
MRNejadnik, AG Mikos, JAJansen, SCGLeeuwenburgh. Facilitating the mineralization of oligo(poly(ethylene glycol) fumarate) hydrogel by incorporation of hydroxyapatite nanoparticles. J Biomed Mater Res A 2012; 100(5): 1316–1323
https://doi.org/10.1002/jbm.a.34071
pmid: 22374694
|
18 |
SSamavedi, AR Whittington, ASGoldstein. Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior. Acta Biomater 2013; 9(9): 8037–8045
https://doi.org/10.1016/j.actbio.2013.06.014
pmid: 23791671
|
19 |
GWei, Q Jin, WVGiannobile, PXMa. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 2007; 28(12): 2087–2096
https://doi.org/10.1016/j.biomaterials.2006.12.028
pmid: 17239946
|
20 |
RZhang, PX Ma. Poly(α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res 1999; 44(4): 446–455
https://doi.org/10.1002/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F
pmid: 10397949
|
21 |
SKango, S Kalia, ACelli, JNjuguna, YHabibi, RKumar. Surface modification of inorganic nanoparticles for development of organic-inorganic nanocomposites—a review. Prog Polym Sci 2013; 38(8): 1232–1261
https://doi.org/10.1016/j.progpolymsci.2013.02.003
|
22 |
SPina, JM Oliveira, RLReis. Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review. Adv Mater 2015; 27(7): 1143–1169
https://doi.org/10.1002/adma.201403354
pmid: 25580589
|
23 |
NGSahoo, YZ Pan, LLi, CBHe. Nanocomposites for bone tissue regeneration. Nanomedicine (Lond) 2013; 8(4): 639–653
https://doi.org/10.2217/nnm.13.44
pmid: 23560413
|
24 |
PXMa, R Zhang, GXiao, RFranceschi. Engineering new bone tissue in vitro on highly porous poly(α-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res 2001; 54(2): 284–293
https://doi.org/10.1002/1097-4636(200102)54:2<284::AID-JBM16>3.0.CO;2-W
pmid: 11093189
|
25 |
SShinzato, T Nakamura, KAndo, TKokubo, YKitamura. Mechanical properties and osteoconductivity of new bioactive composites consisting of partially crystallized glass beads and poly(methyl methacrylate). J Biomed Mater Res 2002; 60(4): 556–563
https://doi.org/10.1002/jbm.10098
pmid: 11948514
|
26 |
VAKoleganova, SM Bernier, SJDixon, ASRizkalla. Bioactive glass/polymer composite materials with mechanical properties matching those of cortical bone. J Biomed Mater Res A 2006; 77(3): 572–579
https://doi.org/10.1002/jbm.a.30561
pmid: 16506172
|
27 |
MMarcolongo, P Ducheyne, JGarino, ESchepers. Bioactive glass fiber/polymeric composites bond to bone tissue. J Biomed Mater Res 1998; 39(1): 161–170
https://doi.org/10.1002/(SICI)1097-4636(199801)39:1<161::AID-JBM18>3.0.CO;2-I
pmid: 9429107
|
28 |
PKerativitayanan, AK Gaharwar. Elastomeric and mechanically stiff nanocomposites from poly(glycerol sebacate) and bioactive nanosilicates. Acta Biomater 2015; 26: 34–44
https://doi.org/10.1016/j.actbio.2015.08.025
pmid: 26297886
|
29 |
XZhao, Y Wu, YDu, XChen, B Lei, YXue, PXMa. A highly bioactive and biodegradable poly(glycerol sebacate)–silica glass hybrid elastomer with tailored mechanical properties for bone tissue regeneration. J Mater Chem B Mater Biol Med 2015; 3(16): 3222–3233
https://doi.org/10.1039/C4TB01693A
|
30 |
YZDu, M Yu, JGe, PXMa, XF Chen, BLei. Development of a multifunctional platform based on strong, intrinsically photoluminescent and antimicrobial silica-poly(citrates)-based hybrid biodegradable elastomers for bone regeneration. Adv Funct Mater 2015; 25(31): 5016–5029
https://doi.org/10.1002/adfm.201501712
|
31 |
YZDu, J Ge, YPShao, PXMa, XF Chen, BLei. Development of silica grafted poly(1,8-octanediol-co-citrates) hybrid elastomers with highly tunable mechanical properties and biocompatibility. J Mater Chem B Mater Biol Med 2015; 3(15): 2986–3000
https://doi.org/10.1039/C4TB02089H
|
32 |
RBalint, NJ Cassidy, SHCartmell. Conductive polymers: towards a smart biomaterial for tissue engineering. Acta Biomater 2014; 10(6): 2341–2353
https://doi.org/10.1016/j.actbio.2014.02.015
pmid: 24556448
|
33 |
ELHopley, S Salmasi, DMKalaskar, AMSeifalian. Carbon nanotubes leading the way forward in new generation 3D tissue engineering. Biotechnol Adv 2014; 32(5): 1000–1014
https://doi.org/10.1016/j.biotechadv.2014.05.003
pmid: 24858314
|
34 |
XLiu, JM Holzwarth, PXMa. Functionalized synthetic biodegradable polymer scaffolds for tissue engineering. Macromol Biosci 2012; 12(7): 911–919
https://doi.org/10.1002/mabi.201100466
pmid: 22396193
|
35 |
JRJones. Review of bioactive glass: from Hench to hybrids. Acta Biomater 2013; 9(1): 4457–4486
https://doi.org/10.1016/j.actbio.2012.08.023
pmid: 22922331
|
36 |
BLei, XF Chen, YJWang, NZhao. Synthesis and in vitro bioactivity of novel mesoporous hollow bioactive glass microspheres. Mater Lett 2009; 63(20): 1719–1721
https://doi.org/10.1016/j.matlet.2009.04.041
|
37 |
BLei, X Chen, YWang, NZhao, C Du, LFang. Surface nanoscale patterning of bioactive glass to support cellular growth and differentiation. J Biomed Mater Res A 2010; 94(4): 1091–1099
pmid: 20694976
|
38 |
XFChen, B Lei, YJWang, NZhao. Morphological control and in vitro bioactivity of nanoscale bioactive glasses. J Non-Cryst Solids 2009; 355(13): 791–796
https://doi.org/10.1016/j.jnoncrysol.2009.02.005
|
39 |
SMZakaria, SH Sharif Zein, MROthman, FYang, JA Jansen. Nanophase hydroxyapatite as a biomaterial in advanced hard tissue engineering: a review. Tissue Eng Part B Rev 2013; 19(5): 431–441
https://doi.org/10.1089/ten.teb.2012.0624
pmid: 23557483
|
40 |
ARBoccaccini, M Erol, WJStark, DMohn, ZK Hong, JFMano. Polymer/bioactive glass nanocomposites for biomedical applications: a review. Compos Sci Technol 2010; 70(13): 1764–1776
https://doi.org/10.1016/j.compscitech.2010.06.002
|
41 |
BLei, KH Shin, DYNoh, YHKoh, WY Choi, HEKim. Bioactive glass microspheres as reinforcement for improving the mechanical properties and biological performance of poly(e-caprolactone) polymer for bone tissue regeneration. J Biomed Mater Res Part B Appl Biomater 2012; 100B (4): 967–975
https://doi.org/10.1002/jbm.b.32659
|
42 |
BLei, XF Chen, XHan, JAZhou. Versatile fabrication of nanoscale sol-gel bioactive glass particles for efficient bone tissue regeneration. J Mater Chem 2012; 22(33): 16906–16913
https://doi.org/10.1039/c2jm31384g
|
43 |
BLei, KH Shin, DYNoh, IHJo, YH Koh, HEKim, SEKim. Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering. Mater Sci Eng C 2013; 33(3): 1102–1108
https://doi.org/10.1016/j.msec.2012.11.039
pmid: 23827548
|
44 |
SIRoohani-Esfahani, SNouri-Khorasani, ZLu, R Appleyard, HZreiqat. The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials 2010; 31(21): 5498–5509
https://doi.org/10.1016/j.biomaterials.2010.03.058
pmid: 20398935
|
45 |
MNRahaman, DE Day, BSBal, QFu, SB Jung, LFBonewald, APTomsia. Bioactive glass in tissue engineering. Acta Biomater 2011; 7(6): 2355–2373
https://doi.org/10.1016/j.actbio.2011.03.016
pmid: 21421084
|
46 |
MPeter, NS Binulal, SVNair, NSelvamurugan, HTamura, RJayakumar. Novel biodegradable chitosan-gelatin/nano-bioactive glass ceramic composite scaffolds for alveolar bone tissue engineering. Chem Eng J 2010; 158(2): 353–361
https://doi.org/10.1016/j.cej.2010.02.003
|
47 |
MMozafari, F Moztarzadeh, MRabiee, MAzami, SMaleknia, MTahriri, ZMoztarzadeh, NNezafati. Development of macroporous nanocomposite scaffolds of gelatin/bioactive glass prepared through layer solvent casting combined with lamination technique for bone tissue engineering. Ceram Int 2010; 36(8): 2431–2439
https://doi.org/10.1016/j.ceramint.2010.07.010
|
48 |
ZHong, RL Reis, JFMano. Preparation and in vitro characterization of scaffolds of poly(L-lactic acid) containing bioactive glass ceramic nanoparticles. Acta Biomater 2008; 4(5): 1297–1306
https://doi.org/10.1016/j.actbio.2008.03.007
pmid: 18439885
|
49 |
XLiu, LA Smith, JHu, PXMa. Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials 2009; 30(12): 2252–2258
https://doi.org/10.1016/j.biomaterials.2008.12.068
pmid: 19152974
|
50 |
CHe, G Xiao, XJin, CSun, PX Ma. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography. Adv Funct Mater 2010; 20(20): 3568–3576
https://doi.org/10.1002/adfm.201000993
pmid: 21673827
|
51 |
BLei, L Wang, XFChen, SKChae. Biomimetic and molecular level-based silicate bioactive glass-gelatin hybrid implants for loading-bearing bone fixation and repair. J Mater Chem B Mater Biol Med 2013; 1(38): 5153–5162
https://doi.org/10.1039/c3tb20941e
|
52 |
JChen, W Que, YXing, BLei. Molecular level-based bioactive glass-poly (caprolactone) hybrids monoliths with porous structure for bone tissue repair. Ceram Int 2015; 41(2): 3330–3334
https://doi.org/10.1016/j.ceramint.2014.10.147
|
53 |
MXie, J Ge, BLei, QZhang, XChen, PX Ma. Star-shaped, biodegradable, and elastomeric PLLA-PEG-POSS hybrid membrane with biomineralization activity for guiding bone tissue regeneration. Macromol Biosci 2015; 15(12): 1656–1662
https://doi.org/10.1002/mabi.201500237
pmid: 26241149
|
54 |
JChen, Y Du, WQue, YXing, X Chen, BLei. Crack-free polydimethylsiloxane-bioactive glass-poly(ethylene glycol) hybrid monoliths with controlled biomineralization activity and mechanical property for bone tissue regeneration. Colloids Surf B Biointerfaces 2015; 136: 126–133
https://doi.org/10.1016/j.colsurfb.2015.08.053
pmid: 26381696
|
55 |
JChen, YZ Du, WXQue, YLXing, BLei. Content-dependent biomineralization activity and mechanical properties based on polydimethylsiloxane-bioactive glass-poly(caprolactone) hybrids monoliths for bone tissue regeneration. Rsc Adv. 2015; 5(75): 61309–61317
https://doi.org/10.1039/C5RA09075J
|
56 |
BLei, KH Shin, YWMoon, DYNoh, YH Koh, YJin, HEKim. Synthesis and bioactivity of sol-gel derived porous, bioactive glass microspheres using chitosan as novel biomolecular template. J Am Ceram Soc 2012; 95(1): 30–33
https://doi.org/10.1111/j.1551-2916.2011.04918.x
|
57 |
OMahony, O Tsigkou, CIonescu, CMinelli, LLing, R Hanly, MESmith, MMStevens, JRJones. Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration. Adv Funct Mater 2010; 20(22): 3835–3845
https://doi.org/10.1002/adfm.201000838
|
58 |
BLei, KH Shin, IHJo, YHKoh, HE Kim. Highly porous gelatin-silica hybrid scaffolds with textured surfaces using new direct foaming/freezing technique. Mater Chem Phys 2014; 145(3): 397–402
https://doi.org/10.1016/j.matchemphys.2013.09.057
|
59 |
BLei, KH Shin, DYNoh, IHJo, YH Koh, WYChoi, HEKim. Nanofibrous gelatin-silica hybrid scaffolds mimicking the native extracellular matrix (ECM) using thermally induced phase separation. J Mater Chem 2012; 22(28): 14133–14140
https://doi.org/10.1039/c2jm31290e
|
60 |
YMXue, L Wang, YPShao, JYan, XF Chen, BLei. Facile and green fabrication of biomimetic gelatin-siloxane hybrid hydrogel with highly elastic properties for biomedical applications. Chem Eng J 2014; 251: 158–164
https://doi.org/10.1016/j.cej.2014.04.049
|
61 |
SDuan, X Yang, FMei, YTang, X Li, YShi, JMao, H Zhang, QCai. Enhanced osteogenic differentiation of mesenchymal stem cells on poly(L-lactide) nanofibrous scaffolds containing carbon nanomaterials. J Biomed Mater Res A 2015; 103(4): 1424–1435
https://doi.org/10.1002/jbm.a.35283
pmid: 25046153
|
62 |
BSitharaman, X Shi, XFWalboomers, HLiao, V Cuijpers, LJWilson, AGMikos, JAJansen. In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineering. Bone 2008; 43(2): 362–370
https://doi.org/10.1016/j.bone.2008.04.013
pmid: 18541467
|
63 |
SPark, J Park, IJo, SPCho, D Sung, SRyu, MPark, KA Min, JKim, SHong, BH Hong, BSKim. In situ hybridization of carbon nanotubes with bacterial cellulose for three-dimensional hybrid bioscaffolds. Biomaterials 2015; 58: 93–102
https://doi.org/10.1016/j.biomaterials.2015.04.027
pmid: 25941786
|
64 |
IAWBSiqueira, MAF Corat, BCavalcanti, WARibeiro Neto, AAMartin, REBretas, FRMarciano, AOLobo. In vitro and in vivo studies of novel poly(D,L-lactic acid), superhydrophilic carbon nanotubes, and nanohydroxyapatite scaffolds for bone regeneration. ACS Appl Mater Interfaces 2015; 7(18): 9385–9398
https://doi.org/10.1021/acsami.5b01066
pmid: 25899398
|
65 |
PEMikael, AR Amini, JBasu, MJosefina Arellano-Jimenez, CTLaurencin, MMSanders, CBarry Carter, SPNukavarapu. Functionalized carbon nanotube reinforced scaffolds for bone regenerative engineering: fabrication, in vitro and in vivo evaluation. Biomed Mater 2014; 9(3): 035001
https://doi.org/10.1088/1748-6041/9/3/035001
pmid: 24687391
|
66 |
EHirata, C Ménard-Moyon, EVenturelli, HTakita, FWatari, ABianco, AYokoyama. Carbon nanotubes functionalized with fibroblast growth factor accelerate proliferation of bone marrow-derived stromal cells and bone formation. Nanotechnology 2013; 24(43): 435101
https://doi.org/10.1088/0957-4484/24/43/435101
pmid: 24077482
|
67 |
BDas, P Chattopadhyay, SMaji, AUpadhyay, MDas Purkayastha, CLMohanta, TKMaity, NKarak. Bio-functionalized MWCNT/hyperbranched polyurethane bionanocomposite for bone regeneration. Biomed Mater 2015; 10(2): 025011
https://doi.org/10.1088/1748-6041/10/2/025011
pmid: 25886640
|
68 |
BLei, KH Shin, YHKoh, HEKim. Porous gelatin-siloxane hybrid scaffolds with biomimetic structure and properties for bone tissue regeneration. J Biomed Mater Res B Appl Biomater 2014; 102(7): 1528–1536
https://doi.org/10.1002/jbm.b.33133
pmid: 24596176
|
69 |
DLNettles, A Chilkoti, LASetton. Applications of elastin-like polypeptides in tissue engineering. Adv Drug Deliv Rev 2010; 62(15): 1479–1485
https://doi.org/10.1016/j.addr.2010.04.002
pmid: 20385185
|
70 |
QZChen, SL Liang, GAThouas. Elastomeric biomaterials for tissue engineering. Prog Polym Sci 2013; 38(3-4): 584–671
https://doi.org/10.1016/j.progpolymsci.2012.05.003
|
71 |
SSant, CM Hwang, SHLee, AKhademhosseini. Hybrid PGS-PCL microfibrous scaffolds with improved mechanical and biological properties. J Tissue Eng Regen Med 2011; 5(4): 283–291
https://doi.org/10.1002/term.313
pmid: 20669260
|
72 |
MKharaziha, M Nikkhah, SRShin, NAnnabi, NMasoumi, AKGaharwar, GCamci-Unal, AKhademhosseini. PGS:Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues. Biomaterials 2013; 34(27): 6355–6366
https://doi.org/10.1016/j.biomaterials.2013.04.045
pmid: 23747008
|
73 |
LBokobza. Mechanical, electrical and spectroscopic investigations of carbon nanotube-reinforced elastomers. Vib Spectrosc 2009; 51(1): 52–59
https://doi.org/10.1016/j.vibspec.2008.10.001
|
74 |
AHPei, JM Malho, JRuokolainen, QZhou, LA Berglund. Strong nanocomposite reinforcement effects in polyurethane elastomer with low volume fraction of cellulose nanocrystals. Macromolecules 2011; 44(11): 4422–4427
https://doi.org/10.1021/ma200318k
|
75 |
DRPaul, JE Mark. Fillers for polysiloxane (“silicone”) elastomers. Prog Polym Sci 2010; 35(7): 893–901
https://doi.org/10.1016/j.progpolymsci.2010.03.004
|
76 |
AMoradi, A Dalilottojari, BPingguan-Murphy, IDjordjevic. Fabrication and characterization of elastomeric scaffolds comprised of a citric acid-based polyester/hydroxyapatite microcomposite. Mater Des 2013; 50: 446–450
https://doi.org/10.1016/j.matdes.2013.03.026
|
77 |
SLLiang, WD Cook, GAThouas, QZChen. The mechanical characteristics and in vitro biocompatibility of poly(glycerol sebacate)-bioglass elastomeric composites. Biomaterials 2010; 31(33): 8516–8529
https://doi.org/10.1016/j.biomaterials.2010.07.105
pmid: 20739061
|
78 |
YDu, M Yu, XChen, PXMa, B Lei. Development of biodegradable poly(citrate)-polyhedral oligomeric silsesquioxanes hybrid elastomers with high mechanical properties and osteogenic differentiation activity. ACS Appl Mater Interfaces 2016; 8(5): 3079–3091
https://doi.org/10.1021/acsami.5b10378
pmid: 26765285
|
79 |
YDu, Y Xue, PXMa, XChen, B Lei. Biodegradable, elastomeric, and intrinsically photoluminescent poly(silicon-citrates) with high photostability and biocompatibility for tissue regeneration and bioimaging. Adv Healthc Mater 2016; 5(3): 382–392
https://doi.org/10.1002/adhm.201500643
pmid: 26687865
|
80 |
NKGuimard, N Gomez, CESchmidt. Conducting polymers in biomedical engineering. Prog Polym Sci 2007; 32(8-9): 876–921
https://doi.org/10.1016/j.progpolymsci.2007.05.012
|
81 |
AOPatil, AJ Heeger, FWudl. Optical-properties of conducting polymers. Chem Rev 1988; 88(1): 183–200
https://doi.org/10.1021/cr00083a009
|
82 |
BLGuo, L Glavas, ACAlbertsson. Biodegradable and electrically conducting polymers for biomedical applications. Prog Polym Sci 2013; 38(9): 1263–1286
https://doi.org/10.1016/j.progpolymsci.2013.06.003
|
83 |
MXie, L Wang, JGe, BGuo, PX Ma. Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniline trimer for bone tissue engineering. ACS Appl Mater Interfaces 2015; 7(12): 6772–6781
https://doi.org/10.1021/acsami.5b00191
pmid: 25742188
|
84 |
MXie, L Wang, BGuo, ZWang, YE Chen, PXMa. Ductile electroactive biodegradable hyperbranched polylactide copolymers enhancing myoblast differentiation. Biomaterials 2015; 71: 158–167
https://doi.org/10.1016/j.biomaterials.2015.08.042
pmid: 26335860
|
85 |
JGHardy, SA Geissler, DAguilar Jr, MKVillancio-Wolter, DJMouser, RCSukhavasi, RCCornelison, LWTien, RCPreda, RSHayden, JKChow, LNguy, DL Kaplan, CESchmidt. Instructive conductive 3D silk foam-based bone tissue scaffolds enable electrical stimulation of stem cells for enhanced osteogenic differentiation. Macromol Biosci 2015; 15(11): 1490–1496
https://doi.org/10.1002/mabi.201500171
pmid: 26033953
|
86 |
SMeng, Z Zhang, MRouabhia. Accelerated osteoblast mineralization on a conductive substrate by multiple electrical stimulation. J Bone Miner Metab 2011; 29(5): 535–544
https://doi.org/10.1007/s00774-010-0257-1
pmid: 21327884
|
87 |
SMeng, M Rouabhia, ZZhang. Electrical stimulation modulates osteoblast proliferation and bone protein production through heparin-bioactivated conductive scaffolds. Bioelectromagnetics 2013; 34(3): 189–199
https://doi.org/10.1002/bem.21766
pmid: 23124591
|
88 |
MYazdimamaghani, M Razavi, MMozafari, DVashaee, HKotturi, LTayebi. Biomineralization and biocompatibility studies of bone conductive scaffolds containing poly(3,4-ethylenedioxythiophene): poly(4-styrene sulfonate) (PEDOT:PSS). J Mater Sci Mater Med 2015; 26(12):274
https://doi.org/10.1007/s10856-015-5599-8
pmid: 26543020
|
89 |
JPelto, M Björninen, APälli, ETalvitie, JHyttinen, BMannerström, RSuuronen Seppanen, MKellomäki, SMiettinen, SHaimi. Novel polypyrrole-coated polylactide scaffolds enhance adipose stem cell proliferation and early osteogenic differentiation. Tissue Eng Part A 2013; 19(7-8): 882–892
https://doi.org/10.1089/ten.tea.2012.0111
pmid: 23126228
|
90 |
BGuo, B Lei, PLi, PXMa. Functionalized scaffolds to enhance tissue regeneration. Regen Biomater 2015; 2(1): 47–57
https://doi.org/10.1093/rb/rbu016
pmid: 25844177
|
91 |
TJiang, EJ Carbone, KWHLo, CTLaurencin. Electrospinning of polymer nanofibers for tissue regeneration. Prog Polym Sci 2015; 46: 1–24
https://doi.org/10.1016/j.progpolymsci.2014.12.001
|
92 |
ODSchneider, F Weber, TJBrunner, SLoher, MEhrbar, PRSchmidlin, WJStark. In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects. Acta Biomater 2009; 5(5): 1775–1784
https://doi.org/10.1016/j.actbio.2008.11.030
pmid: 19121610
|
93 |
EJLee, DS Shin, HEKim, HWKim, YH Koh, JHJang. Membrane of hybrid chitosan-silica xerogel for guided bone regeneration. Biomaterials 2009; 30(5): 743–750
https://doi.org/10.1016/j.biomaterials.2008.10.025
pmid: 19027950
|
94 |
MXie, J Ge, YXue, YDu, B Lei, PXMa. Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation. J Mech Behav Biomed Mater 2015; 51: 163–168
https://doi.org/10.1016/j.jmbbm.2015.07.011
pmid: 26253207
|
95 |
LCLi, M Yu, PXMa, BLGuo. Electroactive degradable copolymers enhancing osteogenic differentiation from bone marrow derived mesenchymal stem cells. J Mater Chem B Mater Biol Med 2016; 4(3): 471–481
https://doi.org/10.1039/C5TB01899D
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