Please wait a minute...
Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2019, Vol. 13 Issue (2) : 189-201    https://doi.org/10.1007/s11684-018-0664-6
REVIEW
Hybrid polymer biomaterials for bone tissue regeneration
Bo Lei1, Baolin Guo1, Kunal J. Rambhia2, Peter X. Ma1,2,3,4,5()
1. Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China
2. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
3. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA
4. Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA
5. Department of Material Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA
 Download: PDF(2591 KB)   HTML
 Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract

Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the extracellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further exemplifies their applications for bone tissue regeneration.

Keywords hybrid polymer      bone regeneration      tissue engineering      biomaterials     
Corresponding Author(s): Peter X. Ma   
Just Accepted Date: 04 September 2018   Online First Date: 31 October 2018    Issue Date: 28 March 2019
 Cite this article:   
Bo Lei,Baolin Guo,Kunal J. Rambhia, et al. Hybrid polymer biomaterials for bone tissue regeneration[J]. Front. Med., 2019, 13(2): 189-201.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-018-0664-6
https://academic.hep.com.cn/fmd/EN/Y2019/V13/I2/189
Fig.1  Bioactive glass particles reinforced PCL osteoconductive hybrid polymers. Reproduced from Ref. [41] with permission.
Fig.2  Schematic illustration of a hypothesized mechanism for the growth of calcium phosphate crystals over time. When a deposition voltage is applied, pH in the vicinity of electrode increases, and some calcium phosphate crystals deposited onto the surface of PLLA nanofibers. Further increase of deposition time leads to the generation of hydrogen bubbles and larger flower-like crystals. Reproduced from Ref. [50] with permission.
Fig.3  Formation mechanism of the biomimetic siloxane-gelatin (SGT) hybrid bone implants. (A–C) Molecular structure and composition of gelatin (GT) (A), siloxane (GS), silicate bioactive glass sol (S); (D–F) GT (D) polymer matrix was cross-linked by GS (E), and then hybridized with the SBG sol at the molecular and nanoscale levels (F); (G and H) semi-transparent SGT hybrid implants with different SBG weight percent, formed after condensation and drying. Reproduced from Ref. [51] with permission from the Royal Society of Chemistry.
Fig.4  Schematic diagram showing an experimental procedure for producing anisotropic porous gelatin-silica hybrid polymer scaffolds by ammonium hydroxide treatment. Reproduced from Ref. [68] with permission.
Fig.5  Porous morphology of gelatin-silica hybrid polymer scaffolds. (A, C) Transverse direction; (B, D) Axial direction. Reproduced from Ref. [68] with permission.
Fig.6  Schematic diagram showing an experimental procedure for producing nanofibrous gelatin-silica hybrid scaffolds by the thermally induced phase separation (TIPS) technique using the mixtures of the gelatin solution and sol–gel derived silica sol. Reproduced from Ref. [59] with permission from the Royal Society of Chemistry.
Fig.7  Synthesis of multifunctional silica-poly(citrate)-based hybrid prepolymers and elastomers. (A,B) Fabrication of multifunctional silica-poly(citrate) (MSPC)?and crosslinked?MSPC (CMSPC) elastomers?by?polycondensation?of citric acid (CA), 1,8-octylene glycol (OD), aminosilane (AS),?as?well?as?the?chemical?crosslinking?with hexamethylene diisocyanate?(HDI) and (C) schematic diagram showing the formation of CMSPC hybrid elastomers matrix. Reproduced from Ref. [30] with permission.
Fig.8  Schematic illustration for preparing poly(glycerol sebacate)-silica-calcium (PGSSC) hybrid elastomers. (A) Synthesis of PGS pre-polymers; (B) formation of silica-based bioactive glass sols; (C) fabrication of PGSSC hybrid elastomers; (D) optical images of PGS and PGSSC hybrid elastomers: (a) PGS; (b) PGS15mol%Si (PGS15Si); and (c) PGS-15mol%Si-20mol%Ca (PGS15Si20Ca). Reproduced from Ref. [29] with permission from the Royal Society of Chemistry.
Fig.9  In vitro biomineralization activity and osteoblast biocompatibility (MC3T3-E1) of BG micro-nanoscale particles-PCL hybrid polymers. (A, B) Apatite formation on surface of PCL (A) and BG-PCL (B) after soaking in SBF for 7 days; (C, D) Cell attachment morphology on the surface of PCL (C) and BG-PCL (D) after culture for 3 days. Reproduced from Refs. [41] and [43] with permission.
Fig.10  Quantitative RT-PCR results of bone sialoprotein (BSP)(A) and osteocalcin (OCN)(B) gene expression. MC3T3-E1 cells were cultured on NF-gelatin and NF-gelatin/apatite scaffolds for 1 and 4 weeks. The Y-axis of the figure is the gene expression results normalized by β actin. * represents statistically significant differences (P<0.05). Reproduced from Ref. [49] with permission.
Fig.11  Micro-computed tomography of the cranial defects (diameter=6 mm) in New Zealand White rabbits after 4-week implantation using PLGA, PLGA/TCP composites. (A, B) Two examples of the CT of the entire cranial bone are shown. Defect margins and treatment modalities are indicated. Adapted from Ref. [92] with permission.
Fig.12  Optical micrographs of the rat bone tissue regeneration responses after the 3 weeks implantation of the membranes: (A, C) pure chitosan and (B, D) the chitosan–silica xerogel hybrid. The fresh-formed bone tissue was revealed in blue, the calcified bones and materials were stained in red. Reproduced from Ref. [93] with permission.
1 FMWatt, WTS Huck. Role of the extracellular matrix in regulating stem cell fate. Nat Rev Mol Cell Biol 2013; 14(8): 467–473
https://doi.org/10.1038/nrm3620 pmid: 23839578
2 IEErickson, SR Kestle, KHZellars, MJFarrell, MKim, JA Burdick, RLMauck. High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties. Acta Biomater 2012; 8(8): 3027–3034
https://doi.org/10.1016/j.actbio.2012.04.033 pmid: 22546516
3 SSLee, BJ Huang, SRKaltz, SSur, CJ Newcomb, SRStock, RNShah, SIStupp. Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds. Biomaterials 2013; 34(2): 452–459
https://doi.org/10.1016/j.biomaterials.2012.10.005 pmid: 23099062
4 SVDorozhkin. Calcium orthophosphate-containing biocomposites and hybrid biomaterials for biomedical applications. J Funct Biomater 2015; 6(3): 708–832
https://doi.org/10.3390/jfb6030708 pmid: 26262645
5 WWu, WG Wang, JSLi. Star polymers: advances in biomedical applications. Prog Polym Sci 2015; 46: 55–85
https://doi.org/10.1016/j.progpolymsci.2015.02.002
6 JNicolas, S Mura, DBrambilla, NMackiewicz, PCouvreur. Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery. Chem Soc Rev 2013; 42(3): 1147–1235
https://doi.org/10.1039/C2CS35265F pmid: 23238558
7 HYTian, ZH Tang, XLZhuang, XSChen, XBJing. Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Prog Polym Sci 2012; 37(2): 237–280
https://doi.org/10.1016/j.progpolymsci.2011.06.004
8 ZPan, J Ding. Poly(lactide-co-glycolide) porous scaffolds for tissue engineering and regenerative medicine. Interface Focus 2012; 2(3): 366–377
https://doi.org/10.1098/rsfs.2011.0123 pmid: 23741612
9 JCIgwe, PE Mikael, SPNukavarapu. Design, fabrication and in vitro evaluation of a novel polymer-hydrogel hybrid scaffold for bone tissue engineering. J Tissue Eng Regen Med 2014; 8(2): 131–142
https://doi.org/10.1002/term.1506 pmid: 22689304
10 JVenkatesan, I Bhatnagar, PManivasagan, KHKang, SKKim. Alginate composites for bone tissue engineering: a review. Int J Biol Macromol 2015; 72: 269–281
https://doi.org/10.1016/j.ijbiomac.2014.07.008 pmid: 25020082
11 JVenkatesan, PA Vinodhini, PNSudha, SKKim. Chitin and chitosan composites for bone tissue regeneration. Adv Food Nutr Res 2014;73: 59–81 PMID: 25300543
https://doi.org/10.1016/B978-0-12-800268-1.00005-6
12 RYunus Basha, TSSampath Kumar, MDoble. Design of biocomposite materials for bone tissue regeneration. Mater Sci Eng C 2015; 57: 452–463
https://doi.org/10.1016/j.msec.2015.07.016 pmid: 26354284
13 FSun, H Zhou, JLee. Various preparation methods of highly porous hydroxyapatite/polymer nanoscale biocomposites for bone regeneration. Acta Biomater 2011; 7(11): 3813–3828
https://doi.org/10.1016/j.actbio.2011.07.002 pmid: 21784182
14 KGkioni, SCG Leeuwenburgh, TELDouglas, AGMikos, JAJansen. Mineralization of hydrogels for bone regeneration. Tissue Eng Part B Rev 2010; 16(6): 577–585
https://doi.org/10.1089/ten.teb.2010.0462 pmid: 20735319
15 QWei, J Lu, QWang, HFan, X Zhang. Novel synthesis strategy for composite hydrogel of collagen/hydroxyapatite-microsphere originating from conversion of CaCO3 templates. Nanotechnology 2015; 26(11): 115605
https://doi.org/10.1088/0957-4484/26/11/115605 pmid: 25719911
16 TNVo, SR Shah, SLu, AMTatara, EJLee, TT Roh, YTabata, AGMikos. Injectable dual-gelling cell-laden composite hydrogels for bone tissue engineering. Biomaterials 2016; 83: 1–11
https://doi.org/10.1016/j.biomaterials.2015.12.026 pmid: 26773659
17 MRNejadnik, AG Mikos, JAJansen, SCGLeeuwenburgh. Facilitating the mineralization of oligo(poly(ethylene glycol) fumarate) hydrogel by incorporation of hydroxyapatite nanoparticles. J Biomed Mater Res A 2012; 100(5): 1316–1323
https://doi.org/10.1002/jbm.a.34071 pmid: 22374694
18 SSamavedi, AR Whittington, ASGoldstein. Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior. Acta Biomater 2013; 9(9): 8037–8045
https://doi.org/10.1016/j.actbio.2013.06.014 pmid: 23791671
19 GWei, Q Jin, WVGiannobile, PXMa. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 2007; 28(12): 2087–2096
https://doi.org/10.1016/j.biomaterials.2006.12.028 pmid: 17239946
20 RZhang, PX Ma. Poly(α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res 1999; 44(4): 446–455
https://doi.org/10.1002/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F pmid: 10397949
21 SKango, S Kalia, ACelli, JNjuguna, YHabibi, RKumar. Surface modification of inorganic nanoparticles for development of organic-inorganic nanocomposites—a review. Prog Polym Sci 2013; 38(8): 1232–1261
https://doi.org/10.1016/j.progpolymsci.2013.02.003
22 SPina, JM Oliveira, RLReis. Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review. Adv Mater 2015; 27(7): 1143–1169
https://doi.org/10.1002/adma.201403354 pmid: 25580589
23 NGSahoo, YZ Pan, LLi, CBHe. Nanocomposites for bone tissue regeneration. Nanomedicine (Lond) 2013; 8(4): 639–653
https://doi.org/10.2217/nnm.13.44 pmid: 23560413
24 PXMa, R Zhang, GXiao, RFranceschi. Engineering new bone tissue in vitro on highly porous poly(α-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res 2001; 54(2): 284–293
https://doi.org/10.1002/1097-4636(200102)54:2<284::AID-JBM16>3.0.CO;2-W pmid: 11093189
25 SShinzato, T Nakamura, KAndo, TKokubo, YKitamura. Mechanical properties and osteoconductivity of new bioactive composites consisting of partially crystallized glass beads and poly(methyl methacrylate). J Biomed Mater Res 2002; 60(4): 556–563
https://doi.org/10.1002/jbm.10098 pmid: 11948514
26 VAKoleganova, SM Bernier, SJDixon, ASRizkalla. Bioactive glass/polymer composite materials with mechanical properties matching those of cortical bone. J Biomed Mater Res A 2006; 77(3): 572–579
https://doi.org/10.1002/jbm.a.30561 pmid: 16506172
27 MMarcolongo, P Ducheyne, JGarino, ESchepers. Bioactive glass fiber/polymeric composites bond to bone tissue. J Biomed Mater Res 1998; 39(1): 161–170
https://doi.org/10.1002/(SICI)1097-4636(199801)39:1<161::AID-JBM18>3.0.CO;2-I pmid: 9429107
28 PKerativitayanan, AK Gaharwar. Elastomeric and mechanically stiff nanocomposites from poly(glycerol sebacate) and bioactive nanosilicates. Acta Biomater 2015; 26: 34–44
https://doi.org/10.1016/j.actbio.2015.08.025 pmid: 26297886
29 XZhao, Y Wu, YDu, XChen, B Lei, YXue, PXMa. A highly bioactive and biodegradable poly(glycerol sebacate)–silica glass hybrid elastomer with tailored mechanical properties for bone tissue regeneration. J Mater Chem B Mater Biol Med 2015; 3(16): 3222–3233
https://doi.org/10.1039/C4TB01693A
30 YZDu, M Yu, JGe, PXMa, XF Chen, BLei. Development of a multifunctional platform based on strong, intrinsically photoluminescent and antimicrobial silica-poly(citrates)-based hybrid biodegradable elastomers for bone regeneration. Adv Funct Mater 2015; 25(31): 5016–5029
https://doi.org/10.1002/adfm.201501712
31 YZDu, J Ge, YPShao, PXMa, XF Chen, BLei. Development of silica grafted poly(1,8-octanediol-co-citrates) hybrid elastomers with highly tunable mechanical properties and biocompatibility. J Mater Chem B Mater Biol Med 2015; 3(15): 2986–3000
https://doi.org/10.1039/C4TB02089H
32 RBalint, NJ Cassidy, SHCartmell. Conductive polymers: towards a smart biomaterial for tissue engineering. Acta Biomater 2014; 10(6): 2341–2353
https://doi.org/10.1016/j.actbio.2014.02.015 pmid: 24556448
33 ELHopley, S Salmasi, DMKalaskar, AMSeifalian. Carbon nanotubes leading the way forward in new generation 3D tissue engineering. Biotechnol Adv 2014; 32(5): 1000–1014
https://doi.org/10.1016/j.biotechadv.2014.05.003 pmid: 24858314
34 XLiu, JM Holzwarth, PXMa. Functionalized synthetic biodegradable polymer scaffolds for tissue engineering. Macromol Biosci 2012; 12(7): 911–919
https://doi.org/10.1002/mabi.201100466 pmid: 22396193
35 JRJones. Review of bioactive glass: from Hench to hybrids. Acta Biomater 2013; 9(1): 4457–4486
https://doi.org/10.1016/j.actbio.2012.08.023 pmid: 22922331
36 BLei, XF Chen, YJWang, NZhao. Synthesis and in vitro bioactivity of novel mesoporous hollow bioactive glass microspheres. Mater Lett 2009; 63(20): 1719–1721
https://doi.org/10.1016/j.matlet.2009.04.041
37 BLei, X Chen, YWang, NZhao, C Du, LFang. Surface nanoscale patterning of bioactive glass to support cellular growth and differentiation. J Biomed Mater Res A 2010; 94(4): 1091–1099
pmid: 20694976
38 XFChen, B Lei, YJWang, NZhao. Morphological control and in vitro bioactivity of nanoscale bioactive glasses. J Non-Cryst Solids 2009; 355(13): 791–796
https://doi.org/10.1016/j.jnoncrysol.2009.02.005
39 SMZakaria, SH Sharif Zein, MROthman, FYang, JA Jansen. Nanophase hydroxyapatite as a biomaterial in advanced hard tissue engineering: a review. Tissue Eng Part B Rev 2013; 19(5): 431–441
https://doi.org/10.1089/ten.teb.2012.0624 pmid: 23557483
40 ARBoccaccini, M Erol, WJStark, DMohn, ZK Hong, JFMano. Polymer/bioactive glass nanocomposites for biomedical applications: a review. Compos Sci Technol 2010; 70(13): 1764–1776
https://doi.org/10.1016/j.compscitech.2010.06.002
41 BLei, KH Shin, DYNoh, YHKoh, WY Choi, HEKim. Bioactive glass microspheres as reinforcement for improving the mechanical properties and biological performance of poly(e-caprolactone) polymer for bone tissue regeneration. J Biomed Mater Res Part B Appl Biomater 2012; 100B (4): 967–975
https://doi.org/10.1002/jbm.b.32659
42 BLei, XF Chen, XHan, JAZhou. Versatile fabrication of nanoscale sol-gel bioactive glass particles for efficient bone tissue regeneration. J Mater Chem 2012; 22(33): 16906–16913
https://doi.org/10.1039/c2jm31384g
43 BLei, KH Shin, DYNoh, IHJo, YH Koh, HEKim, SEKim. Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering. Mater Sci Eng C 2013; 33(3): 1102–1108
https://doi.org/10.1016/j.msec.2012.11.039 pmid: 23827548
44 SIRoohani-Esfahani, SNouri-Khorasani, ZLu, R Appleyard, HZreiqat. The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials 2010; 31(21): 5498–5509
https://doi.org/10.1016/j.biomaterials.2010.03.058 pmid: 20398935
45 MNRahaman, DE Day, BSBal, QFu, SB Jung, LFBonewald, APTomsia. Bioactive glass in tissue engineering. Acta Biomater 2011; 7(6): 2355–2373
https://doi.org/10.1016/j.actbio.2011.03.016 pmid: 21421084
46 MPeter, NS Binulal, SVNair, NSelvamurugan, HTamura, RJayakumar. Novel biodegradable chitosan-gelatin/nano-bioactive glass ceramic composite scaffolds for alveolar bone tissue engineering. Chem Eng J 2010; 158(2): 353–361
https://doi.org/10.1016/j.cej.2010.02.003
47 MMozafari, F Moztarzadeh, MRabiee, MAzami, SMaleknia, MTahriri, ZMoztarzadeh, NNezafati. Development of macroporous nanocomposite scaffolds of gelatin/bioactive glass prepared through layer solvent casting combined with lamination technique for bone tissue engineering. Ceram Int 2010; 36(8): 2431–2439
https://doi.org/10.1016/j.ceramint.2010.07.010
48 ZHong, RL Reis, JFMano. Preparation and in vitro characterization of scaffolds of poly(L-lactic acid) containing bioactive glass ceramic nanoparticles. Acta Biomater 2008; 4(5): 1297–1306
https://doi.org/10.1016/j.actbio.2008.03.007 pmid: 18439885
49 XLiu, LA Smith, JHu, PXMa. Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials 2009; 30(12): 2252–2258
https://doi.org/10.1016/j.biomaterials.2008.12.068 pmid: 19152974
50 CHe, G Xiao, XJin, CSun, PX Ma. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography. Adv Funct Mater 2010; 20(20): 3568–3576
https://doi.org/10.1002/adfm.201000993 pmid: 21673827
51 BLei, L Wang, XFChen, SKChae. Biomimetic and molecular level-based silicate bioactive glass-gelatin hybrid implants for loading-bearing bone fixation and repair. J Mater Chem B Mater Biol Med 2013; 1(38): 5153–5162
https://doi.org/10.1039/c3tb20941e
52 JChen, W Que, YXing, BLei. Molecular level-based bioactive glass-poly (caprolactone) hybrids monoliths with porous structure for bone tissue repair. Ceram Int 2015; 41(2): 3330–3334
https://doi.org/10.1016/j.ceramint.2014.10.147
53 MXie, J Ge, BLei, QZhang, XChen, PX Ma. Star-shaped, biodegradable, and elastomeric PLLA-PEG-POSS hybrid membrane with biomineralization activity for guiding bone tissue regeneration. Macromol Biosci 2015; 15(12): 1656–1662
https://doi.org/10.1002/mabi.201500237 pmid: 26241149
54 JChen, Y Du, WQue, YXing, X Chen, BLei. Crack-free polydimethylsiloxane-bioactive glass-poly(ethylene glycol) hybrid monoliths with controlled biomineralization activity and mechanical property for bone tissue regeneration. Colloids Surf B Biointerfaces 2015; 136: 126–133
https://doi.org/10.1016/j.colsurfb.2015.08.053 pmid: 26381696
55 JChen, YZ Du, WXQue, YLXing, BLei. Content-dependent biomineralization activity and mechanical properties based on polydimethylsiloxane-bioactive glass-poly(caprolactone) hybrids monoliths for bone tissue regeneration. Rsc Adv. 2015; 5(75): 61309–61317
https://doi.org/10.1039/C5RA09075J
56 BLei, KH Shin, YWMoon, DYNoh, YH Koh, YJin, HEKim. Synthesis and bioactivity of sol-gel derived porous, bioactive glass microspheres using chitosan as novel biomolecular template. J Am Ceram Soc 2012; 95(1): 30–33
https://doi.org/10.1111/j.1551-2916.2011.04918.x
57 OMahony, O Tsigkou, CIonescu, CMinelli, LLing, R Hanly, MESmith, MMStevens, JRJones. Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration. Adv Funct Mater 2010; 20(22): 3835–3845
https://doi.org/10.1002/adfm.201000838
58 BLei, KH Shin, IHJo, YHKoh, HE Kim. Highly porous gelatin-silica hybrid scaffolds with textured surfaces using new direct foaming/freezing technique. Mater Chem Phys 2014; 145(3): 397–402
https://doi.org/10.1016/j.matchemphys.2013.09.057
59 BLei, KH Shin, DYNoh, IHJo, YH Koh, WYChoi, HEKim. Nanofibrous gelatin-silica hybrid scaffolds mimicking the native extracellular matrix (ECM) using thermally induced phase separation. J Mater Chem 2012; 22(28): 14133–14140
https://doi.org/10.1039/c2jm31290e
60 YMXue, L Wang, YPShao, JYan, XF Chen, BLei. Facile and green fabrication of biomimetic gelatin-siloxane hybrid hydrogel with highly elastic properties for biomedical applications. Chem Eng J 2014; 251: 158–164
https://doi.org/10.1016/j.cej.2014.04.049
61 SDuan, X Yang, FMei, YTang, X Li, YShi, JMao, H Zhang, QCai. Enhanced osteogenic differentiation of mesenchymal stem cells on poly(L-lactide) nanofibrous scaffolds containing carbon nanomaterials. J Biomed Mater Res A 2015; 103(4): 1424–1435
https://doi.org/10.1002/jbm.a.35283 pmid: 25046153
62 BSitharaman, X Shi, XFWalboomers, HLiao, V Cuijpers, LJWilson, AGMikos, JAJansen. In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineering. Bone 2008; 43(2): 362–370
https://doi.org/10.1016/j.bone.2008.04.013 pmid: 18541467
63 SPark, J Park, IJo, SPCho, D Sung, SRyu, MPark, KA Min, JKim, SHong, BH Hong, BSKim. In situ hybridization of carbon nanotubes with bacterial cellulose for three-dimensional hybrid bioscaffolds. Biomaterials 2015; 58: 93–102
https://doi.org/10.1016/j.biomaterials.2015.04.027 pmid: 25941786
64 IAWBSiqueira, MAF Corat, BCavalcanti, WARibeiro Neto, AAMartin, REBretas, FRMarciano, AOLobo. In vitro and in vivo studies of novel poly(D,L-lactic acid), superhydrophilic carbon nanotubes, and nanohydroxyapatite scaffolds for bone regeneration. ACS Appl Mater Interfaces 2015; 7(18): 9385–9398
https://doi.org/10.1021/acsami.5b01066 pmid: 25899398
65 PEMikael, AR Amini, JBasu, MJosefina Arellano-Jimenez, CTLaurencin, MMSanders, CBarry Carter, SPNukavarapu. Functionalized carbon nanotube reinforced scaffolds for bone regenerative engineering: fabrication, in vitro and in vivo evaluation. Biomed Mater 2014; 9(3): 035001
https://doi.org/10.1088/1748-6041/9/3/035001 pmid: 24687391
66 EHirata, C Ménard-Moyon, EVenturelli, HTakita, FWatari, ABianco, AYokoyama. Carbon nanotubes functionalized with fibroblast growth factor accelerate proliferation of bone marrow-derived stromal cells and bone formation. Nanotechnology 2013; 24(43): 435101
https://doi.org/10.1088/0957-4484/24/43/435101 pmid: 24077482
67 BDas, P Chattopadhyay, SMaji, AUpadhyay, MDas Purkayastha, CLMohanta, TKMaity, NKarak. Bio-functionalized MWCNT/hyperbranched polyurethane bionanocomposite for bone regeneration. Biomed Mater 2015; 10(2): 025011
https://doi.org/10.1088/1748-6041/10/2/025011 pmid: 25886640
68 BLei, KH Shin, YHKoh, HEKim. Porous gelatin-siloxane hybrid scaffolds with biomimetic structure and properties for bone tissue regeneration. J Biomed Mater Res B Appl Biomater 2014; 102(7): 1528–1536
https://doi.org/10.1002/jbm.b.33133 pmid: 24596176
69 DLNettles, A Chilkoti, LASetton. Applications of elastin-like polypeptides in tissue engineering. Adv Drug Deliv Rev 2010; 62(15): 1479–1485
https://doi.org/10.1016/j.addr.2010.04.002 pmid: 20385185
70 QZChen, SL Liang, GAThouas. Elastomeric biomaterials for tissue engineering. Prog Polym Sci 2013; 38(3-4): 584–671
https://doi.org/10.1016/j.progpolymsci.2012.05.003
71 SSant, CM Hwang, SHLee, AKhademhosseini. Hybrid PGS-PCL microfibrous scaffolds with improved mechanical and biological properties. J Tissue Eng Regen Med 2011; 5(4): 283–291
https://doi.org/10.1002/term.313 pmid: 20669260
72 MKharaziha, M Nikkhah, SRShin, NAnnabi, NMasoumi, AKGaharwar, GCamci-Unal, AKhademhosseini. PGS:Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues. Biomaterials 2013; 34(27): 6355–6366
https://doi.org/10.1016/j.biomaterials.2013.04.045 pmid: 23747008
73 LBokobza. Mechanical, electrical and spectroscopic investigations of carbon nanotube-reinforced elastomers. Vib Spectrosc 2009; 51(1): 52–59
https://doi.org/10.1016/j.vibspec.2008.10.001
74 AHPei, JM Malho, JRuokolainen, QZhou, LA Berglund. Strong nanocomposite reinforcement effects in polyurethane elastomer with low volume fraction of cellulose nanocrystals. Macromolecules 2011; 44(11): 4422–4427
https://doi.org/10.1021/ma200318k
75 DRPaul, JE Mark. Fillers for polysiloxane (“silicone”) elastomers. Prog Polym Sci 2010; 35(7): 893–901
https://doi.org/10.1016/j.progpolymsci.2010.03.004
76 AMoradi, A Dalilottojari, BPingguan-Murphy, IDjordjevic. Fabrication and characterization of elastomeric scaffolds comprised of a citric acid-based polyester/hydroxyapatite microcomposite. Mater Des 2013; 50: 446–450
https://doi.org/10.1016/j.matdes.2013.03.026
77 SLLiang, WD Cook, GAThouas, QZChen. The mechanical characteristics and in vitro biocompatibility of poly(glycerol sebacate)-bioglass elastomeric composites. Biomaterials 2010; 31(33): 8516–8529
https://doi.org/10.1016/j.biomaterials.2010.07.105 pmid: 20739061
78 YDu, M Yu, XChen, PXMa, B Lei. Development of biodegradable poly(citrate)-polyhedral oligomeric silsesquioxanes hybrid elastomers with high mechanical properties and osteogenic differentiation activity. ACS Appl Mater Interfaces 2016; 8(5): 3079–3091
https://doi.org/10.1021/acsami.5b10378 pmid: 26765285
79 YDu, Y Xue, PXMa, XChen, B Lei. Biodegradable, elastomeric, and intrinsically photoluminescent poly(silicon-citrates) with high photostability and biocompatibility for tissue regeneration and bioimaging. Adv Healthc Mater 2016; 5(3): 382–392
https://doi.org/10.1002/adhm.201500643 pmid: 26687865
80 NKGuimard, N Gomez, CESchmidt. Conducting polymers in biomedical engineering. Prog Polym Sci 2007; 32(8-9): 876–921
https://doi.org/10.1016/j.progpolymsci.2007.05.012
81 AOPatil, AJ Heeger, FWudl. Optical-properties of conducting polymers. Chem Rev 1988; 88(1): 183–200
https://doi.org/10.1021/cr00083a009
82 BLGuo, L Glavas, ACAlbertsson. Biodegradable and electrically conducting polymers for biomedical applications. Prog Polym Sci 2013; 38(9): 1263–1286
https://doi.org/10.1016/j.progpolymsci.2013.06.003
83 MXie, L Wang, JGe, BGuo, PX Ma. Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniline trimer for bone tissue engineering. ACS Appl Mater Interfaces 2015; 7(12): 6772–6781
https://doi.org/10.1021/acsami.5b00191 pmid: 25742188
84 MXie, L Wang, BGuo, ZWang, YE Chen, PXMa. Ductile electroactive biodegradable hyperbranched polylactide copolymers enhancing myoblast differentiation. Biomaterials 2015; 71: 158–167
https://doi.org/10.1016/j.biomaterials.2015.08.042 pmid: 26335860
85 JGHardy, SA Geissler, DAguilar Jr, MKVillancio-Wolter, DJMouser, RCSukhavasi, RCCornelison, LWTien, RCPreda, RSHayden, JKChow, LNguy, DL Kaplan, CESchmidt. Instructive conductive 3D silk foam-based bone tissue scaffolds enable electrical stimulation of stem cells for enhanced osteogenic differentiation. Macromol Biosci 2015; 15(11): 1490–1496
https://doi.org/10.1002/mabi.201500171 pmid: 26033953
86 SMeng, Z Zhang, MRouabhia. Accelerated osteoblast mineralization on a conductive substrate by multiple electrical stimulation. J Bone Miner Metab 2011; 29(5): 535–544
https://doi.org/10.1007/s00774-010-0257-1 pmid: 21327884
87 SMeng, M Rouabhia, ZZhang. Electrical stimulation modulates osteoblast proliferation and bone protein production through heparin-bioactivated conductive scaffolds. Bioelectromagnetics 2013; 34(3): 189–199
https://doi.org/10.1002/bem.21766 pmid: 23124591
88 MYazdimamaghani, M Razavi, MMozafari, DVashaee, HKotturi, LTayebi. Biomineralization and biocompatibility studies of bone conductive scaffolds containing poly(3,4-ethylenedioxythiophene): poly(4-styrene sulfonate) (PEDOT:PSS). J Mater Sci Mater Med 2015; 26(12):274
https://doi.org/10.1007/s10856-015-5599-8 pmid: 26543020
89 JPelto, M Björninen, APälli, ETalvitie, JHyttinen, BMannerström, RSuuronen Seppanen, MKellomäki, SMiettinen, SHaimi. Novel polypyrrole-coated polylactide scaffolds enhance adipose stem cell proliferation and early osteogenic differentiation. Tissue Eng Part A 2013; 19(7-8): 882–892
https://doi.org/10.1089/ten.tea.2012.0111 pmid: 23126228
90 BGuo, B Lei, PLi, PXMa. Functionalized scaffolds to enhance tissue regeneration. Regen Biomater 2015; 2(1): 47–57
https://doi.org/10.1093/rb/rbu016 pmid: 25844177
91 TJiang, EJ Carbone, KWHLo, CTLaurencin. Electrospinning of polymer nanofibers for tissue regeneration. Prog Polym Sci 2015; 46: 1–24
https://doi.org/10.1016/j.progpolymsci.2014.12.001
92 ODSchneider, F Weber, TJBrunner, SLoher, MEhrbar, PRSchmidlin, WJStark. In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects. Acta Biomater 2009; 5(5): 1775–1784
https://doi.org/10.1016/j.actbio.2008.11.030 pmid: 19121610
93 EJLee, DS Shin, HEKim, HWKim, YH Koh, JHJang. Membrane of hybrid chitosan-silica xerogel for guided bone regeneration. Biomaterials 2009; 30(5): 743–750
https://doi.org/10.1016/j.biomaterials.2008.10.025 pmid: 19027950
94 MXie, J Ge, YXue, YDu, B Lei, PXMa. Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation. J Mech Behav Biomed Mater 2015; 51: 163–168
https://doi.org/10.1016/j.jmbbm.2015.07.011 pmid: 26253207
95 LCLi, M Yu, PXMa, BLGuo. Electroactive degradable copolymers enhancing osteogenic differentiation from bone marrow derived mesenchymal stem cells. J Mater Chem B Mater Biol Med 2016; 4(3): 471–481
https://doi.org/10.1039/C5TB01899D
[1] Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian. Current advances for bone regeneration based on tissue engineering strategies[J]. Front. Med., 2019, 13(2): 160-188.
[2] Xiaosong Gu. Progress and perspectives of neural tissue engineering[J]. Front. Med., 2015, 9(4): 401-411.
[3] Zhiyuan Zhang. Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region[J]. Front Med, 2011, 5(4): 401-413.
[4] Hengyun SUN, Wei LIU, Guangdong ZHOU, Wenjie ZHANG, Lei CUI, Yilin CAO. Tissue engineering of cartilage, tendon and bone[J]. Front Med, 2011, 5(1): 61-69.
[5] DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping. Current progress on scaffolds of tissue engineering heart valves[J]. Front. Med., 2008, 2(3): 229-234.
[6] GE Jian, LIU Jingbo. The stem cell and tissue engineering research in Chinese ophthalmology[J]. Front. Med., 2007, 1(1): 6-10.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed