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Interplay between diet and genetic susceptibility in obesity and related traits |
Tiange Wang, Min Xu, Yufang Bi, Guang Ning() |
State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health, National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China |
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Abstract The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.
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Keywords
diet
genetic susceptibility
obesity
interaction
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Corresponding Author(s):
Guang Ning
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Just Accepted Date: 06 September 2018
Online First Date: 07 November 2018
Issue Date: 03 December 2018
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