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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

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2018 Impact Factor: 1.847

Front. Med.    2018, Vol. 12 Issue (6) : 624-633    https://doi.org/10.1007/s11684-018-0669-1
REVIEW
Early-onset diabetes: an epidemic in China
Jiemin Pan, Weiping Jia()
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai 200233, China
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Abstract

Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.

Keywords diabetes      early-onset      diabetes complications     
Corresponding Author(s): Weiping Jia   
Just Accepted Date: 14 September 2018   Online First Date: 02 November 2018    Issue Date: 03 December 2018
 Cite this article:   
Jiemin Pan,Weiping Jia. Early-onset diabetes: an epidemic in China[J]. Front. Med., 2018, 12(6): 624-633.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-018-0669-1
https://academic.hep.com.cn/fmd/EN/Y2018/V12/I6/624
Modifiable Non-modifiable
Obesity Ethnicity (Han, Manchu)
Low physical activity Family history of T2DM
High sedentary behavior Puberty
Socioeconomic status Low birth weight
Male sex
Intrauterine hyperglycemia
Previous gestational diabetes
Tab.1  Risk factors for early-onset type 2 diabetes
CINDI 2a MI Constantinob JADEc
Diabetes duration Newly diagnosed 11.6 10
Neuropathy 13.2 11
Retinopathy 5.06 37 20
Nephropathy 0.93 10
Microalbuminuria 47.4
Ischemic heart disease 0.66 2.5 5
Peripheral vascular disease 2 14.4 7
Cerebrovascular disease 0.13 4.3 2
Tab.2  The prevalence of macrovascular and microvascular complications among individuals with early-onset diabetes
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