Association of <italic>SIPA1</italic> 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

doi:10.1007/s11684-013-0247-5

Front Med

2013, Vol. 7

Issue (1) : 138-142 https://doi.org/10.1007/s11684-013-0247-5

RESEARCH ARTICLE

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie(

)

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center, Beijing Cancer Hospital & Institute, Peking University Cancer Hospital, Beijing 100142, China

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Abstract

It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastatic efficiency in both human and rodents. The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastatic breast cancer. In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Survival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-Meier method with log-rank tests. We found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185 patients with metastatic breast cancer. Patients with SIPA1 545 T/T genotype had a significantly worse overall survival (OS) than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained an independent unfavorable prognostic marker of OS in this cohort (hazard ratio [HR] = 2.16; 95% CI= 1.12–4.15; P = 0.022). Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival compared to patients with C/C or C/T genotype.

Keywords SIPA1 polymorphism metastatic breast cancer survival

Corresponding Author(s): Xie Yuntao,Email:zlxyt2@bjmu.edu.cn

Issue Date: 05 March 2013

Cite this article:

Renling Pei,Ye Xu,Yan Wei, et al. Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer[J]. Front Med, 2013, 7(1): 138-142.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-013-0247-5
https://academic.hep.com.cn/fmd/EN/Y2013/V7/I1/138

Tab.1 Association of 545 C>T polymorphism with clinicopathological characteristics in 185 breast cancer patients

Tab.2 The correlation between patients characteristics and overall survival

Fig.1 Kaplan-Meier estimate of overall survival by 545 C>T polymorphism in 185 metastatic breast cancer patients.

Tab.3 Multivariate analyses of overall survival in 185 breast cancer patients

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