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Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters |
Fen LAN, Shengdao XIONG(), Weining XIONG, Guopeng XU, Xiaoxia LU |
Department of Respiratory Medicine, Key Laboratory of Pulmonary Diseases of Ministry of Health of China, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430300, China |
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Abstract This study aims to research the expression of spleen tyrosine kinase (Syk) in non-small cell lung cancer (NSCLC) and the relationship between Syk and clinicopathologic factors and p53. Immunohistochemistry was applied to detect the expression of Syk and p53 protein in 39 cases of NSCLC (23 cases of lung squamous cell cancer, 16 cases of lung adenocarcinoma) and tumor-surrounding normal lung tissues. The positive rate of Syk was 46.15% (18/39) and 100% (39/39) in NSCLC and tumor-surrounding normal lung tissues, respectively. The expression level of Syk in NSCLC was significantly lower than that in tumor-surrounding normal lung tissues (P = 0.000). The Syk expression was positively correlated withthe p53 expression in NSCLC specimens (P = 0.025). There was no significant association between Syk expression and lymph node metastasis, differentiation degree, tumor size and tumor node metastasis (TNM). The present study demonstrated that Syk was aberrantly expressed in the NSCLC and might have a significant impact on tumor growth and progression.
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Keywords
Syk kinase
carcinoma, non-small-cell lung
tumor suppressor protein p53
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Corresponding Author(s):
XIONG Shengdao,Email:sdxiong@tjh.tjmu.edu.cn
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Issue Date: 05 March 2009
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1 |
Ding Y B, Wu Z Y, Wang S, Fan P, Zha X M, Zheng W, Liu X A. Expression of tyrosine kinase Syk in breast cancer and their clinical significance. Nanjing Yike Daxue Xuebao , 2004,18(3): 128-132 (in Chinese)
|
2 |
Zhang K L, Wang S F, Wen M, Zheng B M, Di W, Li Y Y. The expression and significance of Syk and C-erB-2, PCNA in patients with breast cancer. Zhongguo Aizheng Zazhi , 2006, 15(2): 131-133 (in Chinese)
|
3 |
Nakashima H, Natusugoe S, Ishigami S, Okumura H, Matsumoto M, Hokita S, Aikou T. Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer. Cancer Lett , 2006, 236(1): 89-94 doi: 10.1016/j.canlet.2005.05.022
|
4 |
Qin B S, Li G C. Significance of expression of spleen tyrosine kinase (Syk) in gastric carcinoma. Zhongguo Wuzhenxue Zazhi , 2006, 6: 411-412 (in Chinese)
|
5 |
Xia J G, Ding Y B, Chen G Y. Expression of tyrosine kinase Syk and its clinical significance in gastric carcinoma. Shijie Huaren Xiaohua Zazhi , 2004, 12(4): 767-769 (in Chinese)
|
6 |
Chen M X, Ding Y B, Jiang K R, Mao Y. Expression of tyrosine kinase Syk and its clinical significance in pancreatic cancer. Nanjing Daxue Xuebao , 2003, 23(5): 492-493 (in Chinese)
|
7 |
Sada K, Takano T, Yanaji S, Yamamura H. Structure and function of Syk protein-tyrosine kinase. J Biochem , 2001, 130(2): 177-186
|
8 |
Fujino M, Dosaka-Akita H, Harada M, Hiroumi H, Kinoshita I, Akie K, Kawakami Y. Prognostic significance of p53 and ras p21 expression in non-small cell lung cancer. Cancer , 1995,76(12): 2457-2463 doi: 10.1002/1097-0142(19951215)76:12<2457::AID-CNCR2820761209>3.0.CO;2-X
|
9 |
Okamura S, Ng C C, Koyama K, Takei Y, Arakawa H, Monden M, Nakamura Y. Identification of seven genes regulated by wile-type p53 in a colon cancer cell line carrying a well-controlled wile-type p53 expression system. Oncol Res , 1999,11(6): 281-285
|
10 |
Ding Y B, Wu Z Y, Wang S, Fan P, Zha X M, Zheng W, Liu X A. Expression of tyrosine kinase Syk in breast cancer and their clinical significance. Zhonghua Wai Ke Za Zhi , 2004, 42(3): 137-139 (in Chinese)
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