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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

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Front Med Chin    2009, Vol. 3 Issue (1) : 8-12    https://doi.org/10.1007/s11684-009-0017-6
REVIEW
Protein phosphatase 2A, a key player in Alzheimer’s disease
Rong LIU(), Qing TIAN
Department of Pathophysiology, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract

Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells. In the brains of patients with Alzheimer’s disease (AD), decreased PP2A activities were observed, which is suggested to be involved in neurofibrillary tangle (NFT) formation, disturbed amyloid precursor protein (APP) secretion and neurodegeneration in AD brain. Based on our research and other previous findings, decreased PP2Ac level, decreased PP2A holoenzyme composition, increased level of PP2A inhibitors, increased PP2Ac Leu309 demethylation and Tyr307 phosphorylation underlie PP2A inactivation in AD. β-amyloid (Aβ) over-production, estrogen deficiency and impaired homocysteine metabolism are the possible up-stream factors that inactivate PP2A in AD neurons. Further studies are required to disclose the role of PP2A in Alzheimer’s disease.
Keywords protein phosphatase 2A      Alzheimer’s disease      holoenzyme composition      protein phosphatase 2A inhibitors      Leu309 demethylation      Tyr307 phosphorylation     
Corresponding Author(s): LIU Rong,Email:lilylizzy@yahoo.com.cn   
Issue Date: 05 March 2009
 Cite this article:   
Rong LIU,Qing TIAN. Protein phosphatase 2A, a key player in Alzheimer’s disease[J]. Front Med Chin, 2009, 3(1): 8-12.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-009-0017-6
https://academic.hep.com.cn/fmd/EN/Y2009/V3/I1/8
Fig.1  A summary on roles of protein phosphatase 2A in Alzheimer’s disease. APP: amyloid precursor protein; PP2A: protein phosphatase 2A; Aβ: β-amyloid; L309: Leu309; m: demethylation; Y307: Tyr307; p: phosphorylation; T668: Thr668.
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[1] LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing. Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation[J]. Front. Med., 2008, 2(3): 235-238.
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