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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2008, Vol. 2 Issue (2) : 147-153    https://doi.org/10.1007/s11684-008-0028-8
Mechanisms of the spatial memory deficits induced by injection of okadaic acid into the Meynert nucleus basalis of rats
TIAN Qing, LIU Bin, ZHOU Xinwen, TU Qian, LIU Rong, WANG Jianzhi
Department of Pathophysiology, Hubei Provincial Key Laboratory of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology;
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Abstract We previously reported that the injection of okadaic acid (OA) into the Meynert nucleus basalis of rats induced spatial memory deficits. The present study was designed to further explore the underlying mechanisms. We found that the level of acetylcholine (Ach) in the hippocampus significantly decreased 24 h after injection of OA into the Meynert nucleus basalis of rats. Simultaneously, spatial memory deficit, PP-2A inhibition and tau hyperphosphorylation at Ser-198/Ser-199/Ser-202 (Tau-1 epitope) and Ser-396/Ser-404 (PHF-1 epitope) were observed. With the restoration of hippocampus Ach to normal levels at 48 and 72 h after the injection, the spatial memory deficits, PP-2A inhibition and tau hyperphosphorylation were reversed. It is suggested that injection of OA into the Meynert nucleus basalis of rats may impair the hippocampus-dependent spatial memory through damaging the cholinergic projection between the Meynert nucleus basalis and the hippocampus and the selective inhibition of PP-2A and tau hyperphosphorylation may be at least part of the underlying mechanisms.
Issue Date: 05 June 2008
 Cite this article:   
LIU Bin,TIAN Qing,ZHOU Xinwen, et al. Mechanisms of the spatial memory deficits induced by injection of okadaic acid into the Meynert nucleus basalis of rats[J]. Front. Med., 2008, 2(2): 147-153.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-008-0028-8
https://academic.hep.com.cn/fmd/EN/Y2008/V2/I2/147
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