%A Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
%T Cyclooxygenase-2 gene-1195G/A genotype is associated
with the risk of HBV-induced HCC: A case-control study in Han Chinese
people
%0 Journal Article
%D 2010
%J Front. Med.
%J Frontiers of Medicine
%@ 2095-0217
%R 10.1007/s11684-010-0021-x
%P 90-95
%V 4
%N 1
%U {https://academic.hep.com.cn/fmd/EN/10.1007/s11684-010-0021-x
%8 2010-03-05
%X This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infection. We conducted a population-based, case-control study enrolling 630 Han Chinese people in Hubei province. Subjects included primary HCC patients with HBV infection (n=210), chronic hepatitis B cases (n=210) and healthy Han Chinese (n=210). -1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis. We found-1195A allele carriers had a higher risk of HCC with HBV infection (OR, 0.72; 95% CI, 0.548–0.946). The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.