%A Xinxin Xu, Yinshi Guo, Qiuying Li, Ling Yang, Jianqiang Kang %T Invasive mucinous adenocarcinoma with lepidic-predominant pattern coexisted with tuberculosis: a case report %0 Journal Article %D 2018 %J Front. Med. %J Frontiers of Medicine %@ 2095-0217 %R 10.1007/s11684-017-0545-4 %P 330-333 %V 12 %N 3 %U {https://academic.hep.com.cn/fmd/EN/10.1007/s11684-017-0545-4 %8 2018-05-04 %X

We observed a rare case of invasive mucinous adenocarcinoma (IMA) with a lepidic-predominant pattern accompanied by pulmonary tuberculosis. An 85-year-old man with repeated cough and sputum was admitted to Xinhua Hospital. T-SPOT test result was 212 pg/ml (reference value of negative is<14 pg/ml), Mycobacterium tuberculosis culture was positive, and tuberculin skin test (PPD) was negative (skin induration<5 mm). The patient was treated with several courses of antibiotics and anti-tuberculosis treatments. Repeated chest CT scans showed disease progression. Bronchoscopy yielded negative results. PET-CT scans showed negative results. A percutaneous lung biopsy revealed mucin-secreting cells lining the alveolar walls. IMA with a lepidic-predominant pattern was diagnosed after invasiveness was found after experimental treatments. Simultaneous occurrence of pulmonary tuberculosis and lung cancer are common; however, the present case of IMA having a lepidic-predominant pattern and coexisting with active tuberculosis has not been reported yet.