%A Xiaodong Mo, Xiaojun Huang %T Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation %0 Journal Article %D 2013 %J Front. Med. %J Frontiers of Medicine %@ 2095-0217 %R 10.1007/s11684-013-0279-x %P 306-315 %V 7 %N 3 %U {https://academic.hep.com.cn/fmd/EN/10.1007/s11684-013-0279-x %8 2013-09-05 %X

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options for hematological malignancies, and human leukocyte antigen-partially matched related donors (PMRDs) are a valuable option for HSCT. Several protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide. TCD including CD34+ positive selection and CD3/CD19 depletion has successfully overcome the human leukocyte antigen disparity. However, TCD is associated with prolonged immune deficiencies, increased risks of infectious complications, and high transplantation-related mortality. PMRD HSCT without ex vivo TCD is well developed, and numerous patients have benefitted from it. Here, we review the literature on PMRD HSCT.