%A Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan %T Vaccine therapies for chronic hepatitis B: can we go further? %0 Journal Article %D 2014 %J Front. Med. %J Frontiers of Medicine %@ 2095-0217 %R 10.1007/s11684-014-0313-7 %P 17-23 %V 8 %N 1 %U {https://academic.hep.com.cn/fmd/EN/10.1007/s11684-014-0313-7 %8 2014-04-05 %X

Chronic hepatitis B is a major health burden worldwide. In addition to the recent progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitis B. On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis B patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based therapeutic vaccines, which have undergone clinical trials. The advantages, disadvantages, and future perspectives for these therapeutic vaccines are discussed.