In order to achieve holistic urban plans incorporating transport infrastructure, public space and the behavior of people in these spaces, integration of urban design and computer modeling is a promising way to provide both qualitative and quantitative support to decisionmakers. This paper describes a systematic literature review following a four-part framework. Firstly, to understand the relationship of elements of transport, spaces, and humans, we review policy and urban design strategies for promoting positive interactions. Secondly, we present an overview of the integration methods and strategies used in urban design and policy discourses. Afterward, metrics and approaches for evaluating the effectiveness of integrated plan alternatives are reviewed. Finally, this paper gives a review of state-of-the-art tools with a focus on seven computer simulation paradigms. This article explores mechanisms underlying the complex system of transport, spaces, and humans from a multidisciplinary perspective to provide an integrated toolkit for designers, planners, modelers and decision-makers with the current methods and their challenges.