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Facile preparation of acid/CO2 stimuli-responsive sheddable nanoparticles based on carboxymethylated chitosan |
Weiwei FAN(), Jilu WANG, Jiajun FENG, Yong WANG |
Hubei Collaborative Innovation Center of Targeted Antitumor Drug, College of Chemical Engineering and Pharmacy, Jingchu University of Technology, Jingmen 448000, China |
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Abstract The present study describes the facile preparation of acid/CO2 stimuli-responsive sheddable nanoparticles based on carboxymethylated chitosan (CMCS). Commercially available CMCS was grafted with monomethoxy polyethylene glycol (mPEG) chains via an acid/CO2 responsive linker, i.e., benzoic-imine, and then was used for the cross-linking with CaCl2. With a high CMCS concentration up to 7 mg/mL, stable nanoparticles were successfully prepared. The particle size grew slightly with increasing the molecular weight of mPEG. When the concentration of CaCl2 and the feed ratio of CMCS to mPEG increased, the particle size decreased at first and then increased after reaching a minimum size. When the particles were stimulated by CO2 or acid, benzoic-imine cleaved quickly, and mPEG fell off the nanoparticles simultaneously, and then flocculation and precipitation occurred. These sheddable nanoparticles might have potential application in the biomedical field including the intelligent drug delivery system.
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Keywords
carboxymethylated chitosan
nanoparticles
benzoic-imine
ionic cross-linking
acid-sensitivity
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Corresponding Author(s):
Weiwei FAN
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Online First Date: 01 August 2019
Issue Date: 29 September 2019
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