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The comparison of the Wnt signaling pathway inhibitor delivered electrospun nanoyarn fabricated with two methods for the application of urethroplasty
Xuran GUO,Kaile ZHANG,Mohamed EL-AASSAR,Nanping WANG,Hany EL-HAMSHARY,Mohamed EL-NEWEHY,Qiang FU,Xiumei MO
Front. Mater. Sci.. 2016, 10 (4): 346-357.
https://doi.org/10.1007/s11706-016-0359-3
Urethral strictures were common disease caused by over-expression of extracellular matrix from fibroblast. In this study, we compare two nanoyarn scaffolds for improving fibroblasts infiltration without inhibition the?over-expression of extracellular matrix. Collagen/poly(L-lactide-co-caprolactone)?(Col/P(LLA-CL)) nanoyarn scaffolds were prepared by conjugated electrospinning and dynamic liquid electrospinning, respectively. In addition, co-axial electrospinning technique was combined with the nanoyarn fabrication process to produce nanoyarn scaffolds loading?Wnt?signaling pathway inhibitor. The mechanical properties of the scaffolds were examined and morphology was observed by SEM. Cell morphology, proliferation and infiltration on the scaffolds were investigated by SEM, MTT assay and H&E staining, respectively. The release profiles?of different scaffolds were?determined using?HPLC. The results indicated that cells showed an organized morphology along the?nanoyarns and considerable infiltration?into the nanoyarn scaffolds prepared by dynamic liquid electrospinning (DLY). It was also observed that the DLY significantly facilitate cell proliferation. The D-DLY could facilitate the infiltration of the fibroblasts and could be a promising scaffold for the treatment of urethra stricture while it may inhibit the collagen production.
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Sodium carboxymethylation-functionalized chitosan fibers for cutaneous wound healing application
Dong YAN,Zhong-Zheng ZHOU,Chang-Qing JIANG,Xiao-Jie CHENG,Ming KONG,Ya LIU,Chao FENG,Xi-Guang CHEN
Front. Mater. Sci.. 2016, 10 (4): 358-366.
https://doi.org/10.1007/s11706-016-0353-9
A water absorption biomaterial, sodium carboxymethylation-functionalized chitosan fibers (Na-NOCC fibers) were prepared, applied for cutaneous wound repair, and characterized by FTIR and NMR. The water absorption of Na-NOCC fibers increased significantly with substitution degree rising, from 3.2 to 6.8 g/g, and higher than that of chitosan fibers (2.2 g/g) confirmed by swelling behavior. In the antibacterial action, the high degree of substitution of Na-NOCC fibers exhibited stronger antibacterial activities against E. coli (from 66.54% up to 88.86%). The inhibition of Na-NOCC fibers against S. aureus were above 90%, and more effective than E. coli. The cytotoxicity assay demonstrated that Na-NOCC2 fibers were no obvious cytotoxicity to mouse fibroblasts. Wound healing test and histological examination showed that significantly advanced granulation tissue and capillary formation in the healing-impaired wounds treated with Na-NOCC fibers, as compared to those treated with gauze, which demonstrated that Na-NOCC fibers could promote skin repair and might have great application for wound healing.
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Surfactant-free synthesis of metallic bismuth spheres by microwave-assisted solvothermal approach as a function of the power level
Miriam ESTRADA FLORES,Patricia SANTIAGO JACINTO,Carmen M. REZA SAN GERMÁN,Luis RENDÓN VÁZQUEZ,Raúl BORJA URBY,Nicolás CAYETANO CASTRO
Front. Mater. Sci.. 2016, 10 (4): 394-404.
https://doi.org/10.1007/s11706-016-0356-6
In the present work, the synthesis of micro- and nano-sized spheres of metallic bismuth by microwave-assisted solvothermal method is reported. The synthesis method was carried out at different power levels and at a unique frequency of microwave irradiation. The sphere sizes were controlled by the microwave power level and the concentration of dissolved precursor. Structural and morphological characterization was performed by SEM, HRTEM, EELS and XRD. The results demonstrated that rhombohedral zero valent Bi spheres were synthesized after microwave radiation at 600 and 1200 W. However, if the power level is decreased to 120 W, a monoclinic phase of Bi2O3 is obtained with a flake-like morphology. In comparison with a conventional hydrothermal process, the microwave-assisted solvothermal approach provides many advantages such as shorter reaction time, optimum manipulation of morphologies and provides a specific chemical phase and avoids the mixture of structural phases and morphologies which is essential for further applications such as drug delivery or functionalization with organic materials, thanks to its biocompatibility.
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Electrical properties and thermal sensitivity of Ti/Y modified CuO-based ceramic thermistors
Bao YANG,Hong ZHANG,Jia GUO,Ya LIU,Zhicheng LI
Front. Mater. Sci.. 2016, 10 (4): 413-421.
https://doi.org/10.1007/s11706-016-0355-7
The Ti/Y modified CuO-based negative temperature coefficient (NTC) thermistors, Cu0.988−2yY0.008TiyO (TYCO; y= 0.01, 0.015, 0.03, 0.05 and 0.07), were synthesized through a wet-chemical method followed by a traditional ceramic sintering technology. The related phase component and electrical properties were investigated. XRD results show that the TYCO ceramics have a monoclinic structure as that of CuO crystal. The TYCO ceramics can be obtained at the sintering temperature 970°C–990°C, and display the typical NTC characteristic. The NTC thermal-sensitive constants of TYCO thermistors can be adjusted from 1112 to 3700 K by changing the amount of Ti in the TYCO ceramics. The analysis of complex impedance spectra revealed that both the bulk effect and grain boundary effect contribute to the electrical behavior and the NTC effect. Both the band conduction and electron-hopping models are proposed for the conduction mechanisms in the TYCO thermistors.
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