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Journal of Translational Neuroscience(转化神经科学电子杂志)

ISSN 2096-0689

CN 11-9363/R

Journal of Translational Neuroscience    2020, Vol. 5 Issue (1) : 18-26    https://doi.org/10.3868/j.issn.2096-0689.2020.01.003
Review
The progress in diagnosis and treatment of trigeminal neuralgia
Xiaodong Wang1†, Jian Yang2†, Suping Li1, Maolin Ge1*, Rile Wu3*
1.Department of Emergency Medicine, Inner Mongolia Hospital, People’s Armed Police, Hohhot 010030, China
2.Department of Cardiovascular Medicine, 92493 Military Hospital of the PLA, Huludao, Liaoning 125000, China
3.Department of Neurosurgery, Inner Mongolia Autonomous Region People’s Hospital, Hohhot 010030, China
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Abstract Trigeminal neuralgia (TN) is characterized by recurrent facial acupuncture like, electric shock like, burning like pain and other common clinical cranial nerve diseases in the trigeminal nerve distribution area. Around the world, people who are 40 or more are at risk. The incidence rate of TN of female is slightly higher than that of male and most of the affecting areas are on the right side unilaterally, which affects maxillary nerve and mandibular nerve, yet seldom ophthalmic nerve. Although controversy exists in the pathogenesis of TN, the most accepted theory is microvascular compression, which forces on the demyelination of the sensory axon of the trigeminal nerve root. Additionally, slight touch, conversation and chewing may cause intolerable pain. The diagnosis of TN mainly depends on clinical manifestation. The treatment mainly includes medicine, operation, and some supplementary methods. Among them, antiepileptics and tricyclic antidepressants are the first-line treatment. Surgical treatment is mainly used for patients with TN who have failed in drug treatment or have intolerable side effects. The methods of operation include destructive or non-destructive operation. Deep brain stimulation (DBS) and motor cortex stimulation (MCS) are new therapeutic techniques emerged recently. This method is expected to alleviate the refractory TN with poor drug control or ineffective conventional surgical treatment. At present,this method has not been approved for clinical treatment. Of course, more clinical data collection processes are in progress.
Keywords trigeminal neuralgia (TN)      chronic pain      neuropathic pain      anticonvulsant drugs      microvascular decompression (MVD)      nerve regulation     
Issue Date: 30 March 2020
 Cite this article:   
Xiaodong Wang, Jian Yang, Suping Li, Maolin Ge, Rile Wu. The progress in diagnosis and treatment of trigeminal neuralgia[J]. Journal of Translational Neuroscience,2020, 5(1): 18-26.
 URL:  
https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2020.01.003
https://academic.hep.com.cn/jtn/EN/Y2020/V5/I1/18
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