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Computational fluid dynamics modeling in intracranial atherosclerotic disease
Linfang Lan, Xinyi Leng
Journal of Translational Neuroscience. 2017, 2 (2): 7-15.
https://doi.org/10.3868/j.issn.2096-0689.2017.02.002
Intracranial atherosclerotic disease (ICAD) is an important cause for ischemic stroke and transient ischemic stroke (TIA) throughout the world, especially in Asians, which is not fully appreciated, partly due to its inaccessibility and limitations of current neuroimaging methods. The computational fluid dynamics (CFD) modeling technique provides a novel approach to reveal the hemodynamic characteristics in ICAD, e.g., the distributions of pressure, wall shear stress and flow velocity.In this review article, we aim to provide an overview of the general methodology of CFD modeling in arterial stenotic diseases, the established application of this technique in coronary artery disease, and more importantly,perspectives and challenges of this technique in the investigation of ICAD. Promising findings of preliminary studies using a CFD model for hemodynamic analysis in ICAD warrant verifications. Further studies in this area will help rectify loopholes in the current secondary prevention strategy, and inform individualized treatment for ICAD patients in the near future.
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The effects of hypoxia on major blood components: a brief review
Ming Li, Yang Li, Changhong Ren, Hong An, Fang Jiang, Feng Yan, Sijie Li, Di Wu, Changqing Xia, Xunming Ji
Journal of Translational Neuroscience. 2017, 2 (2): 31-36.
https://doi.org/10.3868/j.issn.2096-0689.2017.02.005
The prevalence of stroke displays obvious geographical variation and is higher on plateaus.Similarly, prolonged stay at high altitude is associated with higher incidence of stroke. High-altitude hypoxia can elicit various physiological dysfunctions, and hypoxia is suggested to be the principal contributing factor of stroke. In this brief review, the effects of hypoxia on the properties of the blood components such as erythrocytes, leukocytes and thrombocytes are presented, in an effort to inform the prevention and treatment of stroke in high-altitude areas.
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5 articles
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