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血管瞬时受体电位通道的生理功能及其异常导致的相关疾病 |
娄杰,张君,李艳超,姜帅,石晶,赵丹,张志仁 |
哈尔滨医科大学附属第二医院, 心肌缺血省部共建教育部重点实验室, 哈尔滨 150086 |
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血管瞬时受体电位通道的生理功能及其异常导致的相关疾病 |
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摘要:瞬时受体电位(transient receptor potential, TRP)通道最早由Cosens和Manning在果蝇突变体的光感受器细胞中发现。在哺乳动物中, TRP通道广泛表达于中枢和外周神经系统。绝大多数TRP离子通道为非电压依赖性、非选择性阳离子通道。在已经被鉴定的30余种存在于哺乳动物中的TRP通道亚型中, 有超过19种在血管中表达, 而血管中的TRP被认为可以通过调控Ca2+内流与释放, 参与调节多种生理功能, 包括调节血管张力、血管通透性、血管分泌功能, 参与机械信号传导等。某些TRP亚型(如TRPC3、TRPC6和TRPV1等)的异常表达与高血压或其他血管疾病密切相关。本文旨在对血管上的TRP通道的生理功能及其异常导致的相关疾病进行概述。
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关键词 :
瞬时受体电位,
非选择性阳离子通道,
血管内皮细胞,
血管平滑肌细胞
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出版日期: 2014-01-02
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