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转化医学研究
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转化医学研究  2013, Vol. 3 Issue (4): 18-26   https://doi.org/10.3868/j.issn.2095-154X.2013.04.002
  综述 本期目录
内皮型一氧化氮合酶翻译后调节的研究进展
孟国梁,单李扬,季勇
江苏省心血管病分子干预重点实验室, 南京医科大学动脉粥样硬化研究中心, 南京 210029
内皮型一氧化氮合酶翻译后调节的研究进展
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摘要:内皮型一氧化氮合酶(endothelial nitric oxide synthase, eNOS)翻译后调节机制复杂, 可直接通过磷酸化、乙酰化等多种形式的修饰改变活性, 同时钙调蛋白、小凹蛋白、热休克蛋白90、G蛋白偶联受体、激酶、骨架蛋白等多种蛋白质可通过与eNOS直接或间接作用, 调节eNOS的活性;BH4和吡哆醇可通过影响脱偶联调控eNOS的活性。对eNOS调节机制的探讨将有利于发现防治内皮功能障碍相关疾病的新靶点。
关键词 内皮型一氧化氮合酶翻译后调节一氧化氮    
出版日期: 2014-01-02
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孟国梁,单李扬,季勇. 内皮型一氧化氮合酶翻译后调节的研究进展[J]. 转化医学研究, 2013, 3(4): 18-26.
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https://academic.hep.com.cn/tmr/CN/Y2013/V3/I4/18
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