Translational research on reprogramming of somatic cells
Yanhua Li1,2, Jie Lin1,3, Changkai Sun1*, Xiaohan Yang, Min Wang4, Mozhen Liu5, Chao Wan6, Qigui Liu1, Anchun Yin5, Jiahui Yin7, Bingbing Zhang1, Ping Zhou4, Bin Feng8*, Fangyi Zhang1, Yongzhong Lin9, Zhanhua Liang5, Jianling Du5, Minghui Lu1, Tiezheng Zheng1, Siyu Liu1, Hao Hong1, Xing Meng1, Dandan Xia1, Yang Sun1, Pan Wei1, Nan Cai1, Hongye Li1, Shuang Wu1, Hui Zhao1, Yuyuan Li1, Changyu Gao1, Wei Li1, Ye Dai1, Junde Wang1, Hui Zhao9, Xiaoxin Tan5, Lili Men5, Hui Ma9, Jun Xu5, Zengchun Hu9, Ling Wang5, Hong Wang5, Pin Sun10, Huifang Guo5, Guirong Song1, Hui Liu11, Baoshuai Shan1, Lu Han1, Linlang Liang3, Xiaochen Wang3, Dan Wang1, Guihua Chen1, Jianting Chen1, Xiangyou Sun1, Jun Xue1, Zhiqi Wang1, Jing Wang1, Yongqing Zhang1, Dongfeng Cai12, Guiping Zhang12, Guoming Luan13*, Jianli Wang14*, Ming Fan15*, Xuetao Cao16*
1. Liaoning Provincial Key Laboratory of Cerebral Diseases,Institute for Brain Disorders,Statistical Analysis Center and Modern Education Technology Center,Dalian Medical University;Dalian 116027,China 2. Dalian Ganjingzi Hospital,Dalian 116033,China 3. Departments of Outpatient,Orthopedics,Endocrinology and Medical Affairs,General Hospital of Shenyang Military Command,Shengyang 110015,China 4. Lab of Information Analysis,Institute of Medical Information,Chinese Academy of Medical Sciences,Beijing 100020,China 5. Departments of Neurology,Orthopedics,Nursing,Endocrinology,Oncology and ENT,First Affiliated Hospital of Dalian Medical University,Dalian 116027,China 6. Medical Affairs Department and Cardiology Department,The 403rd Military Hospital of Dalian,Dalian 116000,China 7. Tongji University Library,Shanghai 200092,China 8. Department of Biotechnology,Dalian Medical University;Dalian 116027,China 9. Departments of Neurology,Pharmacy,Neurosurgery and Physical Examination Center,Second Affiliated Hospital of Dalian Medical University,Dalian 116023,China 10. Shanghai College of Medicine,Fudan University,Shanghai 200433,China 11. Department of Neurology,The 210th Military Hospital of Dalian,Dalian 116000,China 12. Shenyang GE-Software Company,Shengyang 110034,China 13. Sanbo Brain Hospital,Capital Medical University,Beijing 100093,China 14. Institute of Immunology,Zhejiang University,Hangzhou 310027,China 15. Lab of Neurophysiology,Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing 100850,China 16. Chinese Academy of Medical Sciences,Beijing 100073,China
Translational research on reprogramming of somatic cells
摘要:Cerebrovascular diseases,dementia,diabetes,malignant tumors and degenerative bone diseases remain high prevalence,incidence,disability and mortality rates.One important reason might be the slow or stagnated progress in translating and applying cytoprotection and cellular repair researches into clinical practice.Based on collaboration among biomedical researchers,database experts,computer programmers,statisticians and management engineers,this is the first study to apply quantitative comparison on the overall characteristics and partial correlation analysis on the large-scale complex information and data regarding the topic “mature cells can be reprogrammed to become pluripotent” proposed by Sir John B.Gurdon and Shinya Yamanaka who were jointly awarded with 2012 Nobel Prize in Physiology or Medicine,as well as articles that cited publications of the two Nobel Laureates to discuss the prospects of translating somatic cell reprogramming researches into clinical practice and corresponding implementation strategies.The study found that there was statistically significant difference between the two Nobel Laureates with regard to the number,publication date,subject categories and scientific and technological focuses of their original researches.The study revealed the importance,objectives,approaches and research trends of translational medicine,especially translational neuroscience.The study also identified the challenges that China should overcome to improve its medical research management scheme.
Lan Xie,Yong Guo,Guo-liang Huang,Wan-li Xing,Hua-fang Gao,Ling-xiang Zhu,Dong Wang,Guan-bin Zhang,Yi-min Sun,Zhi-wei Zhang,Can Wang,Gao-shan Jing,Wen-yan Qin,Keith Mitchelson,Yu-xiang Zhou,Jing Cheng. Advances in translational medicine for individualized diagnosis of diseases[J]. Translational Medicine Research (Electronic Edition), 2011, 1(1): 46-68.
