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转化医学研究
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转化医学研究  2012, Vol. 2 Issue (1): 54-61   https://doi.org/10.3868/j.issn.2095-154x.2012.01.006
  综述 本期目录
个体化医疗在血液系统疾病的研究进展
菅原,陈文明*
首都医科大学附属北京朝阳医院血液科, 北京 100020
个体化医疗在血液系统疾病的研究进展
 全文: PDF(3107 KB)  
摘要:个体化医疗是对不同个体的基因检测, 了解其对某种疾病的易感情况, 在患病个体中根据不同个体药物遗传学和药物基因组学特点, 采用相关药物方案进行治疗的方法。目前已知多种基因的单核苷酸多态性与疾病的发展、药物的代谢、以及药物作用靶点相关, 检测相关基因型有助于针对不同个体选用不同治疗方案, 从而提高疗效、减少药物不良反应。另外, 血液系统恶性疾病大多伴有染色体异常与融合基因, 对这些基因的检测有助于选用特异性靶向治疗药物进行合理治疗及疾病预后的判断。
关键词 个体化医疗单核苷酸多态性融合基因    
出版日期: 2012-05-23
 引用本文:   
菅原,陈文明*. 个体化医疗在血液系统疾病的研究进展[J]. 转化医学研究, 2012, 2(1): 54-61.
 链接本文:  
https://academic.hep.com.cn/tmr/CN/Y2012/V2/I1/54
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