摘要:The skull base surgery includes excision, restoration and modification of skull base conditions, which consist of trauma,tumors,vascular lesions, congenital abnormalities,and inflammatory focus originating from or involved in skull base. It involves multidisciplinary knowledge including neurosurgery, ophthalmology, orthopedics, otolaryngology and maxillofacial surgery etc. and need assistance and participation of various modern technologies including neuro-monitoring, neuro-navigation and neuro-intervention etc. Because of its deep location, complex anatomical relationships and many important tissues involved ,skull base had been considered insurmountable area of surgery before 1960s. Since the onset of skull base surgery in 1960s, it has developed and strengthened step by step. Now it has step into the era of minimally invasive skull base surgery after the development of two stages of naked eye skull base surgery and microscopic skull base surgery. Its concept is to decrease the damage of normal tissues and completely treat the lesions as far as possible simultaneously by making full use of modern scientific methods and the consummate skills of the operator. One of its characteristics is utilizing the natural intervals to expose the lesions. And the neuroendoscopy can provide a closer look, wide field of vision and a distinct image, so it is fully suitable for the need of modern skull base surgery. After Jankowski treated the pituitary adenomas by endoscopic trans-nasal-sphenoidal approach for the first time in 1992,the endoscopic skull base surgery is gradually becoming mature. With the development of neurosurgical technologies including neuro-monitoring, neuro-navigation and neuro-imaging etc. and the improvement of new apparatus including high speed burrs, laser, microCUSA and holding arms etc., the quality of endoscopic skull base surgery has obtained further improvement. Its advantages include more thorough tumor resection, fewer surgical complications and reductions in operative and hospitalization time. In this paper, we will summarize the advancement of endoscopic skull base surgery in translational medicine.
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