1. LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China 2. National Research Center for Intelligent Computing Systems, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China 3. Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China 4. Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China 5. The Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia
Lack of association between white matter integrity and DISC1 Ser704Cys in a large sample of healthy Han Chinese individuals
摘要:One recent study from a population of 87 healthy UK subjects has reported a significant association of white matter integrity with DISC1 Ser704Cys. Such association is rather impressive, but replication studies in independent populations are necessary. With a large sample of 278 healthy Han Chinese subjects, we carried out the same analyses to test the association of white matter integrity with DISC Ser704Cys, but did not find any significant association. Our results do not support the association between white matter integrity measured by tract-based spatial statistics (TBSS) method and DISC1 Ser704Cys, at least in the Han Chinese population. More replication studies in different population are desired to further test the association.
出版日期: 2015-04-22
引用本文:
Bing Liu,Yong-hui Li,Bing Hou,Chun-shui Yu,Tian-zi Jiang. Lack of association between white matter integrity and DISC1 Ser704Cys in a large sample of healthy Han Chinese individuals[J]. 转化医学研究, 2012, 2(1): 77-80.
