Mechanisms of hyperglycemia-enhanced ischemic brain damage
Andy Li1,2,Qingping He1
1 Department of Pharmaceutical Sciences,Biomanufacturing Research Institute and Technological Enterprise (BRITE),North Carolina Central University,Durham,North Carolina,NC 27707,USA 2 Department of Pathology,Ningxia Key Laboratory for Cerebrocranial Diseases,Ningxia Medical University,Yinchuan 750000,China
Mechanisms of hyperglycemia-enhanced ischemic brain damage
摘要:Almost one third of stroke patients are accompanied with diabetic or nondiabetic hyperglycemia during admission.Hyperglycemia significantly increases brain damage,mortality rate,and long-term disability after cerebral ischemia and reperfusion injury.The mechanisms underlying this important and clinically relevant phenomenon are not fully understood.This paper reviewed the roles of glucose in ischemic brain,influences of hyperglycemia on production of free radicals,changes of mitochondrial ultrastructure and functions,activation of astrocytes,and phosphorylation of MAPK.
出版日期: 2015-04-22
引用本文:
Andy Li,Qingping He. Mechanisms of hyperglycemia-enhanced ischemic brain damage[J]. 转化医学研究, 2013, 3(2): 2-11.