转化医学研究
“中国核心期刊(遴选)数据库”收录期刊
“万方数据—数字化期刊群”全文入网期刊
“中国学术期刊网络出版总库”及CNKI系列数据库收录期刊
“中文科技期刊数据库”收录期刊
   优先出版

当期目录

2012年, 第2卷 第3期 出版日期:2012-03-20 上一期   下一期
选择: 合并摘要 显示/隐藏图片
综述
中国糖尿病防治研究的现状和挑战
康继宏,TiaoGuan,宁光,吴家睿,管又飞
转化医学研究. 2012, 2 (3): 1-11.   DOI: 10.3868/j.issn.2095-154x.2012.03.001
摘要   PDF (11096KB)
糖尿病, 特别是2型糖尿病, 已成为一个全球性的健康威胁。随着中国人民生活水平的提高, 膳食结构和生活方式的改变导致了与糖脂代谢紊乱相关疾病的迅猛增加。其中, 糖尿病人群已接近1亿人, 糖尿病前期人群大约2亿人。糖尿病相关的合并症, 如大血管病变、微血管病变和肿瘤已成为我国人民主要的致死和致残原因。我国糖尿病患者人数的急剧增多的原因可能是遗传和环境因素综合作用的结果, 涉及易感基因、表观遗传作用、糖脂代谢紊乱等众多因素。近年来, 我国在糖尿病流行病学调查、遗传易感基因确定、膳食营养因子作用、胰岛素分泌调节、胰岛素敏感性调控、糖脂代谢紊乱机制、合并症发生机制和防治策略制定方面取得了长足进步。然而, 糖尿病危害的消除还有赖于政府、社会、医药界及患者的共同努力。
相关文章 | 多维度评价
Diabetes research in China: current status and future challenges
Ji-hong Kang,Tiao Guan,Guang Ning,Jia-rui Wu,You-fei Guan
转化医学研究. 2012, 2 (3): 12-24.   DOI: 10.3868/j.issn.2095-154x.2012.03.001EN
摘要   PDF (13646KB)
Diabetes mellitus, especially type 2 diabetes, has become a major health problem worldwide. Improved living standards have led to changes in the diet and lifestyle of the Chinese people, which has resulted in a dramatic increase in the incidence and prevalence of diabetes in China. It is estimated that there are 100 million people in China with diabetes and another 200 million people with prediabetes. Diabetes related diseases, such as macrovascular and microvascular complications and tumors, are considered to be leading causes of death and disability in China. The marked increase in the prevalence of diabetes in China may be attributed to a complex interaction between genetic and environmental factors, involving susceptibility genes, epigenetic modification, and dysregulation of glucose and lipid metabolism. In recent years, China has made enormous progress in understanding diabetes epidemiology, determining susceptible genes, improving insulin secretion and sensitivity in patients, devising strategies to prevent and treat diabetes. However, successful prevention and treatment of diabetes will ultimately require the combined efforts of the government, society, the medical community, the pharmaceutical community, and patients themselves.
相关文章 | 多维度评价
氨基酸偶联糖:新型螯合剂的发展策略
鲁强,赵明,彭师奇,王玉记
转化医学研究. 2012, 2 (3): 25-39.   DOI: 10.3868/j.issn.2095-154x.2012.03.002
摘要   PDF (7281KB)
螯合剂在临床上用于治疗血中重金属, 例如铅、镉和铂等含量超标。由于临床应用的螯合剂大都有严重的毒副作用, 所以急需新型螯合剂。文献报道了一系列新型螯合剂治疗策略。在发展毒副作用最小的螯合剂的过程中, 我们提出了糖和氨基酸偶联的螯合剂治疗策略。本文综述了这种螯合剂治疗策略的进展、特色与优势。
相关文章 | 多维度评价
Conjugating glycoside with amino acid: a strategy to develop new chelating
Qiang Lu,Ming Zhao,Shi-qi Peng,Yu-ji Wang
转化医学研究. 2012, 2 (3): 40-54.   DOI: 10.3868/j.issn.2095-154x.2012.03.002EN
摘要   PDF (8299KB)
Chelation therapy is clinically used if the levels of heavy metals, such as lead, cadmium and platinum, in the blood are abnormal high. Most of clinically used chelating agents have side effects and a series of new chelating agents were investigated. To develop new chelating agents with minimal side effects the conjugates of saccharide and amino acids were discovered. This paper reviewed their potential of heavy metal intoxication in vitro and in vivo, as well as their effect on the levels of essential metals.
相关文章 | 多维度评价
伪肽策略在DNA嵌插剂设计中的应用
蔡青,赵明,彭师奇,吴建辉
转化医学研究. 2012, 2 (3): 55-64.   DOI: 10.3868/j.issn.2095-154x.2012.03.003
摘要   PDF (5928KB)
DNA嵌插剂是临床上是非常重要的一类抗肿瘤药物。在过去的几十年里, 大量策略被用于DNA 嵌插剂设计。其中伪肽策略由于高抗肿瘤疗效和低神经毒性而得到广泛关注。本文综述了伪肽策略的最新进展, 包括结构多样性, 三维定量构效关系, 与DNA的分子对接, 及一些评价抗肿瘤活性或嵌插分子机制的实用的物理化学方法, 例如紫外光谱、荧光光谱、圆二色散光谱、DNA黏度和热变性温度实验研究方法。
相关文章 | 多维度评价
Design of DNA intercalators: a strategy of pseudopeptides
Qing Cai,Ming Zhao,Shi-qi Peng,Jian-hui Wu
转化医学研究. 2012, 2 (3): 65-75.   DOI: 10.3868/j.issn.2095-154x.2012.03.003EN
摘要   PDF (6251KB)
In anti-tumor therapy DNA intercalators are of clinical importance. In the past few decades a number of strategies were used for intercalator design, of the reported strategies pseudo-peptides were specifically designed as a promising strategy, mainly due to their high anti-tumor efficacy and low neural toxicity. In this case, the present paper reviewed the recent progress of pseudo-peptides including their structural diversity, their 3D QSAR, and their docking towards DNA. To emphasize the utility some chemical physical methods either for evaluating the anti-tumor activity or for exploring the molecular mechanism, such as the UV, CD and fluorescence spectra, as well as the temperature melting and viscosity, which reflect the interaction of pseudo-pep- tide with DNA, were also mentioned.
相关文章 | 多维度评价
观点与视角
癫痫的转换医学:我们能走多远?
王学峰
转化医学研究. 2012, 2 (3): 76-80.   DOI: 10.3868/j.issn.2095-154x.2012.03.004
摘要   PDF (3977KB)
相关文章 | 多维度评价
Translational medicine in epilepsy: how much further we can go?
Xue-feng Wang
转化医学研究. 2012, 2 (3): 81-85.   DOI: 10.3868/j.issn.2095-154x.2012.03.004EN
摘要   PDF (4846KB)
相关文章 | 多维度评价
其他
The International Alliance for Translational Neuroscience
转化医学研究. 2012, 2 (3): 0-0.  
摘要   PDF (2771KB)
相关文章 | 多维度评价
国际转化神经科学联盟
转化医学研究. 2012, 2 (3): 0-0.  
摘要   PDF (1854KB)
相关文章 | 多维度评价
10篇文章