转化医学研究
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2012年, 第2卷 第4期 出版日期:2012-04-20 上一期   下一期
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专题—转化神经科学
神经肿瘤的转化医学:机遇与挑战
安德鲁·阿尔布雷特,王永志,李敏*
转化医学研究. 2012, 2 (4): 1-3.   DOI: 10.3868/j.issn.2095-154x.2012.04.001
摘要   PDF (573KB)
胶质母细胞瘤是致死性最强的原发性脑肿瘤, 肿瘤基因组存在着广泛的突变和多个信号通路的失调。肿瘤基因表达谱和非编码小RNA表达谱的深入研究并走向临床应用, 将极大地提高神经肿瘤的临床诊断能力, 进而指导有效治疗。然而, 肿瘤基因表达谱指导下的个体化分子靶向治疗在神经肿瘤领域的研究才刚刚起步。在本文中, 我们探讨了怎样将肿瘤基因组研究成果转化到具体的治疗实践。肿瘤基因组特异性的分子靶向治疗将为最终攻克这些致命性肿瘤带来希望。
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化学前言
我们准备好将预处理诱导的神经保护作用应用于改善患者的预后了吗?
任晓燕,左志义
转化医学研究. 2012, 2 (4): 7-12.   DOI: 10.3868/j.issn.2095-154x.2012.04.002
摘要   PDF (763KB)
对缺血大脑的神经保护一直是医学界的主要需求之一。近年来大脑内源性保护机制受到广泛关注。‘预处理’描述由非致死性的某种刺激引起随后的保护作用的一种现象。目前关于预处理的研究已经找到了多种减轻脑缺血损伤有前景的干预方法。此外,预处理现象的存在使我们可以为近期有脑缺血风险的患者(例如蛛网膜下腔出血的患者在出血14d内发生脑缺血的风险很高)提供预防性的神经保护。本文主要回顾关于预处理神经保护效应的临床相关研究,分析预处理用于改善脑缺血患者预后的应用前景。
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缺血性卒中转化医学研究
杨国源,王继先
转化医学研究. 2012, 2 (4): 20-25.   DOI: 10.3868/j.issn.2095-154x.2012.04.003
摘要   PDF (925KB)
转化医学是近年来医学领域研究的热点, 缺血性卒中转化研究在国内外也有了快速发展。本文介绍了动物模型、药物、干细胞治疗、卒中后康复和治疗性仪器在缺血性卒中中的转化研究现状, 探讨了卒中转化研究面临的挑战, 并指出了加快基础研究与临床应用之间转化的重要性。
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专题—转化神经科学
肿瘤相关癫痫的转化医学研究进展
游赣,江涛*
转化医学研究. 2012, 2 (4): 33-36.   DOI: 10.3868/j.issn.2095-154x.2012.04.004
摘要   PDF (680KB)
转化医学注重多学科的交叉协作, 强调科学研究服务于临床应用, 其本质即为理论联系实际。本文从流行病学特点、发病机制和临床治疗三方面简述肿瘤相关癫痫的研究进展, 旨在为转化医学的进一步发展抛砖引玉。
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综述
生物信息学与转化医学研究
张大保,张敏
转化医学研究. 2012, 2 (4): 41-46.   DOI: 10.3868/j.issn.2095-154x.2012.04.005
摘要   PDF (630KB)
第一份人类基因组草图的完成给生物医学带来了革命性的变化。随着近年来生物技术的迅速发展和电子健康档案在临床医学的广泛应用, 生物信息学作为一门专注于生物医学数据处理的学科变得越来越重要, 尤其是它能促进生物医学知识的转化从而提高临床实践和医疗保健。本文将重点介绍与基础生物学和临床医学有关的数据资源, 以及如何利用生物信息学来整合相关信息, 从而促进转化医学的研究和实践。
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观点与视角
转化针灸学面临的机遇、挑战与对策
岳金换,张秦宏,孙忠人,韩超
转化医学研究. 2012, 2 (4): 53-56.   DOI: 10.3868/j.issn.2095-154x.2012.04.006
摘要   PDF (710KB)
目前, 针灸学基础研究与临床应用脱节日趋严重, 并且现代医学的发展要求针灸学拿出其疗效的客观证据。而转化医学是沟通基础研究与临床应用的桥梁, 是循证医学的延伸, 故转化针灸学应运而生。转化医学的兴起对针灸学的发展是一把双刃剑, 一方面给针灸学发展提供了良好的机遇;另一方面又对针灸学研究提出了更高的要求和挑战。为了实现针灸的现代化、国际化, 探索和发展转化针灸学势在必行。
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转化医学研究国家与机构的文献计量分析
黄芳,王晓民
转化医学研究. 2012, 2 (4): 61-67.   DOI: 10.3868/j.issn.2095-154x.2012.04.007
摘要   PDF (1989KB)
文献计量学是用数学和统计学的方法, 定量地分析一切知识载体的交叉科学。它是集数学、统计学、文献学为一体, 注重量化的综合性知识体系。本文以Web of Scinece数据库中收录的转化医学研究文献的数据为样本, 利用动态网络可视化分析工具Cite Space软件绘制出转化医学2006~2012年的国家、机构共现的知识图谱, 对转化医学研究的国家、机构进行了文献计量分析与研究, 得出转化医学主要研究机构的研究重点与研究方向, 并对中国转化医学研究机构和研究热点进行了分析。
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专题—转化神经科学
Translational medicine in neuro-oncology: opportunities and challenges
AndrewAlbrecht,Yong-zhiWang,MinLi*
转化医学研究. 2012, 2 (4): 4-6.   DOI: 10.3868/j.issn.2095-154x.2012.04.001EN
摘要   PDF (222KB)
Glioblastoma Multiforme (GBM) is the most lethal form of all primary brain tumors, due to its broadly mutated and highly variable set of deregulated signaling pathways. Utilizing the wealth of gene and microRNA profiling information to guide therapeutic options would drastically improve the clinician’s ability to diagnose and effectively treat brain tumor. Personalized molecular targeting of oncogenic signaling pathways in aggressive metastatic brain tumors such GBM is still in its infancy. This article discusses how further study into genotype-specific molecular targeted chemotherapy is neededto efficiently translate genomic information into a more effective treatment against this deadly disease.
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化学前言
Are we ready to apply preconditioning-induced neuroprotection to improve the outcome patients with brain is chemia?
Xiao-yan Ren,Zhi-yi Zuo
转化医学研究. 2012, 2 (4): 13-19.   DOI: 10.3868/j.issn.2095-154x.2012.04.002EN
摘要   PDF (333KB)
Neuroprotection against cerebral ischemia is still a major unfulfilled medical need. Recently, attention has turned to studying the brain,s own endogenous strategies for neuroprotection. Preconditioning, also known as induced toler¬ance to ischemia, is one of these strategies that have been intensively investigated in recent years. Preconditioning describes the phenomenon by which a sub-lethal stimulus confers protection against subsequent detrimental insult-induced injury. Research on preconditioning over the past few decades has brought various promising interventions for reducing ischemic brain injury in patients. Several of these strategies are being tested in randomized clinical trials. Also, the existence of preconditioning phenom¬enon prepares us to the idea that we can prophylactically induce protective effects in patients in whom brain ischemia may oc¬cur during surgery or disease course (for example, patients with subarachnoid hemorrhage are at high risk of brain ischemia within 14 days of the hemorrhage) . In this article, we will review clinically relevant issues relating to preconditioning-induced neuroprotection. Especially, we will discuss the potential of clinical application of preconditioning to improve the outcome pa¬tients with brain ischemia.
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Translationalmedicineresearchofischemicstroke
Guo-yuan Yang,Ji-xian Wang
转化医学研究. 2012, 2 (4): 26-32.   DOI: 10.3868/j.issn.2095-154x.2012.04.003EN
摘要   PDF (1894KB)
Currently translational medicine is a hotspot in medical research field. Translational ischemic stroke research also has rapidly developed worldwide. This article introduced translational stroke research in the development of animal models, drug and stem cell therapy, post-stroke rehabilitation, and therapeutic instruments. Furthermore, the authors discussed challenges of translational ischemic stroke research. Finally, the authors pointed out the importance to accelerate transformation between the basic research and clinical application.
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专题—转化神经科学
Translationalresearchadvancesintumor relatedepileps
Gan You,Tao Jiang*
转化医学研究. 2012, 2 (4): 37-40.   DOI: 10.3868/j.issn.2095-154x.2012.04.004EN
摘要   PDF (360KB)
Translational medicine emphasizes cooperation between subjects and transformation of scientific research to clinical application. Linking theory with practice is the key point. The present review summarized the research advances of tumor-related epilepsy on epidemiology, pathogenesis and clinical treatment, aiming at accelerating the development of Translational medicine.
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综述
Bioinformaticsandtranslationalmedicineresearch
Da-bao Zhang,Min Zhang
转化医学研究. 2012, 2 (4): 47-52.   DOI: 10.3868/j.issn.2095-154x.2012.04.005EN
摘要   PDF (201KB)
The completion of the first draft of the human genome has revolutionized the field of biomedical science. With the recent parallel developments in biotechnologies and widely use of electronic health records in clinical medicine, bioin-formatics as a science of dealing with biomedical data is becoming increasingly important in translating biological knowledge and medical intelligence to help clinical practice and health care. Here we will focus the review on the data resources from both basic biology and clinical medicine, and how bioinformatics can integrate relevant information to improve research and practice of translational medicine.
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观点与视角
Opportunities, challenges and strategies for translational acupuncturology
Jin-huan Yue,Qin-hong Zhang,Zhong-ren Sun,Chao Han
转化医学研究. 2012, 2 (4): 57-60.   DOI: 10.3868/j.issn.2095-154x.2012.04.006EN
摘要   PDF (302KB)
Recently, the basic research of acupuncture is disjointed from clinical application seriously day by day, and ad¬vance in modern medicine requires objective evidence of acupuncturology with its effectiveness. While, translational medicine builds up a bridge for basic research and clinical application, which is a prolongation of evidence-based medicine. Thus, transla¬tional Acupuncturology was born. The rise of translational medicine is a double-edged sword for the development of Acupuncturology. On the one hand, it provides an excellent opportunity for its development; on the other hand, it sets an even higher demand and challenge. It is imperative to explore and develop Translational Acupuncturology in order to make it moderniza¬tion and internationalization.
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Bibliometrical analysis on translational medicine research country and institution
Fang Huang,Xiao-min Wang
转化医学研究. 2012, 2 (4): 68-74.   DOI: 10.3868/j.issn.2095-154x.2012.04.007EN
摘要   PDF (1600KB)
Bibliometrics is a set of methods to quantitatively analyze scientific and technological literature. It is the application of mathematics and statistical methods to books and other media of communication. In this paper, the data resources about translational medicine come from ISI web of science. The author tries to use the information visualization techniques of dynamic network analysis-citespace, draw the knowledge map of the literature’s co-citation map of research country and research institution, play bibliometrical study on translational medicine research country and research institution. Then analyse the translational medicine research institution of China and the hot spots of translational medicine research in China.
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