转化医学研究
“中国核心期刊(遴选)数据库”收录期刊
“万方数据—数字化期刊群”全文入网期刊
“中国学术期刊网络出版总库”及CNKI系列数据库收录期刊
“中文科技期刊数据库”收录期刊
   优先出版

当期目录

2013年, 第3卷 第3期 出版日期:2013-03-20 上一期   下一期
选择: 合并摘要 显示/隐藏图片
综述
网络药理学:中医药与转化医学研究新途径
张博,李慧颖,李梢
转化医学研究. 2013, 3 (3): 1-5.   DOI: 10.3868/j.issn.2095-154X.2013.03.001
摘要   PDF (856KB)
方剂与证候是中医药的重要特色和中心内容。目前, 理解中药方剂与病证的生物学基础是中医药现代研究的一个重点, 亟需新的研究方法和途径。随着系统生物学等交叉学科的兴起, 以生物分子网络为切入点的网络药理学和网络医学有望系统地刻画中医药的整体性特征, 从一个新的视角阐释中医证候的生物学基础和中药方剂的药效物质基础。本文将简要介绍中医药与转化医学的研究现状、生物分子网络在该研究领域中的作用及其应用前景。
相关文章 | 多维度评价
Network pharmacology: a new approach to translational medical research and traditional Chinese medicine
Bo Zhang,Huiying Li,Shao Li
转化医学研究. 2013, 3 (3): 6-11.   DOI: 10.3868/j.issn.2095-154x.2013.03.001EN
摘要   PDF (366KB)
The formulae and ZHENG/syndromes are the key features of traditional Chinese medicine (TCM). Currently, new methods and approaches are urgently needed to understand the biological basis of Chinese herbal formulae and ZHENG/syndromes in translational medical research on Chinese medicine. With the launch of system biology, network medicine and network pharmacology based on bio-molecular networks are expected to systematically describe the holistic characteristics of Chinese medicine, explain the biological basis of ZHENG/syndromes in Chinese medicine and interpret the material basis for the efficacy of traditional Chinese medicine prescriptions from a new perspective. This article will briefly discuss the current state of translational medical research in Chinese medicine, the roles of bio-molecular networks in this research and its prospects for the future application.
相关文章 | 多维度评价
血管新生抑制因子研究进展
张璐,付毅,孔炜
转化医学研究. 2013, 3 (3): 12-19.   DOI: 10.3868/j.issn.2095-154x.2013.03.002
摘要   PDF (853KB)
血管系统是维持机体正常功能和内环境稳态的基础。血管新生是在已有血管的基础上生成新的血管的过程, 是机体生理和病理过程中维持血管系统结构和功能正常的重要手段。体内血管新生的稳态平衡是血管新生促进因子和抑制因子共同作用的结果。血管新生抑制因子的研究对于防治肿瘤的生长和转移及异常血管增生相关疾病有潜在的临床转化意义。本文就迄今已知的内源性血管新生抑制因子及其机制方面的研究进展进行了综述。
相关文章 | 多维度评价
Progress of angiogenesis inhibitors
Lu Zhang,Yi Fu,Wei Kong
转化医学研究. 2013, 3 (3): 20-27.   DOI: 10.3868/j.issn.2095-154x.2013.03.002EN
摘要   PDF (304KB)
Angiogenesis means the formation of new blood vessels through proliferation and migration of endothelium.The homeostasis of vessel system is modulated by angiogenesis stimulators and inhibitors in vivo.The regulation of these factors is associated with the angiogensis-related diseases including cancer.Angiogenesis inhibitors may be applied as a potential therapeutic target for prevention and treatment of cancer and other angiogenesis-related diseases.In this review,we summarized a series of endogenous angiogenesis inhibitors,their related mechanisms and potential applications.
相关文章 | 多维度评价
关于转化医学重大基础设施建设的思考
张鹏,秦岭,成文翔,岳野,虎义平,李金超
转化医学研究. 2013, 3 (3): 28-32.   DOI: 10.3868/j.issn.2095-154x.2013.03.003
摘要   PDF (6705KB)
随着转化医学研究在国际、国内的开展, 越来越多的转化医学中心在我国建立。然而这些转化医学中心多分散在全国各地, 其建立和发展具有较多的随意性, 较难在更高的层面统筹形成合力。如何从国家的层面进行规划进而规范地发展, 急需进行高效、前瞻的顶层设计。国务院发布的《国家重大科技基础设施建设中长期规划(2012—2030年)》为我国的转化医学建设和发展提供了思路指导。如何贯彻并做好文件中的内容是需要每个立志做好转化医学研究的人员仔细考量的。本文作者基于在中国科学院深圳先进技术研究院进行转化医学研究工作的经历, 就如何做好转化医学顶层设计以及具体实施进行了初步的摸索, 期与各位同道一同探讨完善, 为我国的转化医学的发展贡献力量。
相关文章 | 多维度评价
观点与视角
Thinking about the large-scale infrastructure construction of translational medicine
Peng Zhang,Ling Qin,Wenxiang Cheng,YeYue,YipingHu,JinchaoLi
转化医学研究. 2013, 3 (3): 33-38.   DOI: 10.3868/j.issn.2095-154x.2013.03.003EN
摘要   PDF (6511KB)
With the development of translational medicine worldwide, more and more translational medicine centers (TMCs) were established in our country. However, most of the TMCs are scattered all over the country, therefore a close collaboration among these centers is difficult to achieve. Effective management and thorough planning are the urgent needs in national level for standardized development. The State Council issued ‘Outline of the National Program for Long- and Medium-Term Major Scientific and Technological Infrastructure Construction (2012—2013)’ provided a guidance for the translational medicine development in our country. To follow and implement this guideline is the responsibility of the researchers in the field of translational medicine. The authors based on their work experience of Translational Medical Center of Shenzhen Institutes of Advanced technology, Chinese Academy of Sciences, discussed the plan and strategy to implement the constructions of translational medicine system in China. We look forward to making contribution to the development of translational medicine in China together with all researchers.
相关文章 | 多维度评价
综述
药业信息:全球最新药物信息
转化医学研究. 2013, 3 (3): 39-46.   DOI: 10.3868/j.issn.2095-154x.2013.03.004
摘要   PDF (1122KB)
相关文章 | 多维度评价
Pharmaceutical Information:Quarterly review on the most promising drugs in global market
转化医学研究. 2013, 3 (3): 47-55.   DOI: 10.3868/j.issn.2095-154x.2013.03.004EN
摘要   PDF (174KB)
相关文章 | 多维度评价
8篇文章