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当前中国阿尔茨海默病转化医学研究的机遇和挑战———中国科协第89期沙龙纪要
陈之春,钟春玖
转化医学研究. 2014, 4 (3): 1-9.
https://doi.org/10.3868/j.issn.2095-154X.2014.03.001
随着社会老龄化程度日益加剧, 阿尔茨海默病(Alzheimer's disease, AD)已经成为损害中国和全球健康安全的重大疾病, 严重影响社会和谐稳定与经济可持续发展, 亟需有效的预防和治疗措施。然而, AD病理损害机制仍然不明, 10余年来, 针对脑内β-淀粉样蛋白沉积等诸多新药临床试验也先后宣告失败, AD研究似乎陷入了停滞不前状态。为了整合基础、临床研究力量, 发挥中国特色和优势开展协同攻关, 推动中国的AD研究和创新学说发展, 我们在中国科协的支持下于2014年8月中旬举办了一次主题为“基于创新理论的阿尔茨海默病早期诊治新靶标研究”小型研讨会。与会专家认为, 尽管脑淀粉样蛋白异常沉积和tau蛋白过度磷酸化作为AD特异的病理标志已经确定无疑, 但主流的淀粉样蛋白假说已经受到挑战, AD患者脑糖脂代谢异常、环境因素损害等诱发的多级联病理生理反应在AD病理损害机制中的作用受到越来越多的关注。多模式干预、多靶点药物或/和鸡尾酒疗法应该成为AD防治研究的重点。此外, 我们目前还缺乏用于早期诊断和筛查AD的理想生物学标志物, 现有的脑脊液淀粉样蛋白和tau蛋白定量检测、脑葡萄糖和淀粉样蛋白正电子断层扫描虽然能有效诊断AD, 但具有创伤性、操作复杂、费用昂贵等缺点。我们应该加大支持力度, 鼓励寻找临床实用的、血源性AD诊断标志物研究。
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Challenges and opportunities for translational research of Alzheimers disease in China—minutes of the eighty-ninth symposium of China Association for Science and Technology
zhichun Chen,Chunjiu Zhong
转化医学研究. 2014, 4 (3): 10-18.
https://doi.org/10.3868/j.issn.2095-154X.2014.03.001EN
As the social aging emerges,Alzheimers disease (AD) has become a major neurodegenerative disease which severely disrupts the safety of healthcare system in China and the whole world,dramatically affects the social harmony and stability,as well as disadvantages economic sustainable development.Now,we lacks effective prevention and treatment for AD.AD pathogenesis still remains to be clarified.All the clinical trials targeting cerebral amyloid deposition failed.To strengthen the collaboration between basic and clinical researchers,exert Chinese characteristics and advantages in AD studies,and drive the advancement of translational explorations and innovative solutions of AD in China,we held a symposium focusing on early diagnostic and therapeutic targets of the disease based on innovative discoveries.Experts all agree to that the traditional,classical amyloid hypothesis has been challenged and new perspectives are emerging,including the hypothesis of multiple pathogenic cascades induced by glucose and lipid dysmetabolism,and environmental factors.Current reductionism used in drug development is challenged,and new paradigm of drug development based on multiple disciplines and targets should be preferentially encouraged.Apart from currently established biomarker tests based on amyloid pathology and tau pathology,additional tests with the merits of non-invasion,low cost,easy operation and standardization are incredibly demanding.
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Network biomarkers,interaction networks and dynamical network biomarkers in respiratory diseases
Jian Wang,Xiaodan Wu,Luonan Chen,Meiling Jin,Xiangdong Wang
转化医学研究. 2014, 4 (3): 47-47.
https://doi.org/10.3868/j.issn.2095-154X.2014.03.004EN
Disease-specific biomarkers are the indicators which have functional changes during disease development,progression or treatment.Identification and validation of interaction networks and network biomarkers is becoming extremely important in the research of disease-specific biomarkers.This review presented the definition,significance,related research and potential application for network biomarkers,interaction networks and dynamical network biomarkers (DNB).Disease-specific interaction networks,network biomarkers or dynamic network biomarkers can help to understand the molecular mechanism of disease occurrence,risk assessment,disease classification and monitoring,or evaluation of therapeutic response and toxicity.Protein-based dynamical network biomarkers can provide more information to distinguish healthy stages from pre-disease stages,which might contribute ro early diagnosis for patients.The clinical bioinformatics should be an important method for identifying and validating the disease-specific biomarkers
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