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Frontiers of Agriculture in China

ISSN 1673-7334

ISSN 1673-744X(Online)

CN 11-5729/S

Front Agric Chin    2011, Vol. 5 Issue (4) : 594-597    https://doi.org/10.1007/s11703-011-1135-x
RESEARCH ARTICLE
Effects of aflatoxin-detoxifizyme on growth performance and liver biochemical indices of broilers fed with aflatoxin B1
Baojiang CHEN1(), Yong WANG1, Huimin YU2, Qing XU1
1. College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071000, China; 2. Feed Research Institute, Chinese Academy of Agricultural Science, Beijing 100086, China
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Abstract

Aflatoxin-detoxifizyme (ADTZ) was evaluated for its ability to reduce the deleterious effects of aflatoxin B1 (AFB1) in broiler diets. A total of 624 one-day-old AA broilers were randomly divided into 3 treatment groups with 8 replicates each. The control, AFB1 and ADTZ treatments were fed with basal diet, basal diet+ 0.1 mg/kg AFB1 and basal diet+ 0.1 mg/kg AFB1 + 0.3% ADTZ, respectively. The trials lasted 42 days. The results showed that: (1) AFB1 diminished the growth performance of broilers significantly (P<0.01). (2) The AFB1 supplement caused significant alteration of related liver enzyme activities and significantly decreased the body’s antioxidant capacity. (3) Related parameters were returned to normal levels by a 0.3% ADTZ addition to the AFB1-contaminated diet. All the results in the trials indicate that ADTZ has the ability to detoxify AFB1 and recover the negative effects of AFB1.

Keywords aflatoxin-detoxifizyme (ADTZ)      aflatoxin B1(AFB1)      broilers      growth performance      liver biochemical indices     
Corresponding Author(s): CHEN Baojiang,Email:chenbaojiang@sina.vip.com   
Issue Date: 05 December 2011
 Cite this article:   
Yong WANG,Huimin YU,Qing XU, et al. Effects of aflatoxin-detoxifizyme on growth performance and liver biochemical indices of broilers fed with aflatoxin B1[J]. Front Agric Chin, 2011, 5(4): 594-597.
 URL:  
https://academic.hep.com.cn/fag/EN/10.1007/s11703-011-1135-x
https://academic.hep.com.cn/fag/EN/Y2011/V5/I4/594
Item1-21 d21-42 d
Ingredient
Corn54.0559.29
Soybean meal37.1132.99
Soybean oil2.652.72
Fish meal2.001.00
Methionine0.130.04
Lysine0.000.01
Dicalcium phosphate1.371.42
Limestone1.321.16
Salt0.370.37
Premixa)1.001.00
Total100100
Nutrient levels
ME (MJ /kg)12.1212.33
CP2220
Ca1.000.90
AP0.460.43
Lys1.131.00
Met+ Cys0.860.72
Tab.1  Composition and nutrient level of basal diet
PeriodsItemsControlAFB1ADTZ
First phase (1-21 d)ADG/g22.88±0.95a22.09±0.55b22.85±0.30a
ADFI/g35.22±0.77ab34.95±0.61b35.92±0.65a
F/G1.541±0.0611.583±0.0371.572±0.027
Second phase (21-42 d)ADG/g70.37±2.95a66.41±1.98b70.12±2.37a
ADFI /g132.27±2.90b131.11±2.73b135.57±3.76a
F/G1.882±0.074a1.975±0.031b1.934±0.051ab
Whole course of the experiment (1-42 d)ADG/g46.62±1.49a44.25±1.03b46.49±1.17a
ADFI/g83.74±1.49b83.03±1.26b85.74±1.79a
F/G1.797±0.055a1.877±0.027b1.845±0.037b
Tab.2  Effects of ADTZ and AFB on broiler performance
IndexControlAFB1ADTZ
SDH (U/mg prot)3.49±0.61a2.99±0.58b3.52±0.45a
CHE (U/mg prot)58.17±10.7950.75±9.6758.50±8.72
AKP (U/mg prot)879.33±140.90998.67±137.14872.25±178.56
Tab.3  Effects of ADTZ and AFB on hepatic metabolic enzyme activities
IndexControlAFB1ADTZ
GSH-Px (U/mg prot)17.39±1.86a15.63±2.27b16.92±1.84ab
CAT (U/mg prot)9.67±1.288.70±1.049.57±1.92
SOD (U/mg prot)30.92±1.70a29.22±2.19b30.85±2.14ab
GR (U/mg prot)7.85±1.296.90±1.077.63±1.35
MDA (nmol/mg prot)0.641±0.0760.701±0.0770.646±0.072
Tab.4  Effects of ADTZ and AFB on hepatic antioxidant indices
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