Digital transformation provides companies with a productive approach to transforming and upgrading enterprise resources and capabilities and to exploiting external subject forces to unleash and magnify their potential, thus advancing high-quality enterprise development. Therefore, using regression analysis of the data of China's non-financial listed firms from 2007‒2019 obtained by Python, this paper finds that digital transformation has enormously improved enterprise performance. Furthermore, digital transformation has powerfully boosted supply chain integration, which has played a mediation role in the impact of digital transformation on enterprise performance. Finally, entrepreneurship plays a positive moderating effect on enterprise performance through supply chain integration during digital transformation. The further heterogeneity analysis finds that digital transformation performs better in large, public, state-owned, mature, and non-manufacturing (service industry) enterprises. However, the positive effect of digital transformation on enterprise performance and supply chain integration is not significant in small and medium-sized enterprises. Therefore, supply chain integration cannot play a mediating role in the impact of digital transformation of manufacturing enterprises upon their performance. This paper probes the realization mechanism and micro-foundation of digital transformation, and its conclusion contributes to high-quality digital transformation．