Preparation of porcine hemoglobin microcapsules of chitosan-sodium alginate

doi:10.1007/s11458-007-0058-9

Front. Chem. China

2007, Vol. 2

Issue (3) : 315-317 https://doi.org/10.1007/s11458-007-0058-9

Preparation of porcine hemoglobin microcapsules of chitosan-sodium alginate

LI Jun¹, ZHANG Jijuan², ZHAO Xinjuan², YU Yan²

1.Ocean College, Hainan University, Haikou 570228, China; 2.School of Life Sciences and Technology, China Pharmaceutical University, Nanjing 210009, China;

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Abstract Using an emulsification-gelation method, chitosan-sodium alginate-porcine hemoglobin microcapsules were prepared. Results show that these microcapsules have better forms and small granules with 1 ?m size of the mean particle size. They possess a relatively narrow and normal Gaussian distribution. The loading efficiency of porcine hemoglobin (pHb) in microcapsules is more than 90%. The pHb released from microcapsules is extended for more than one month. Chitosan-sodium alginate-hemoglobin micro capsules are expected to become an artificial oxygen-carrying therapeutic agent with sustained release for intravenous injection.

Issue Date: 05 September 2007

Cite this article:

LI Jun,ZHANG Jijuan,ZHAO Xinjuan, et al. Preparation of porcine hemoglobin microcapsules of chitosan-sodium alginate[J]. Front. Chem. China, 2007, 2(3): 315-317.

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https://academic.hep.com.cn/fcc/EN/10.1007/s11458-007-0058-9
https://academic.hep.com.cn/fcc/EN/Y2007/V2/I3/315

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