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Shape-memory and biocompatibility properties of segmented polyurethanes based on poly(L-lactide) |
| PING Peng1, WANG Wenshou1, ZHANG Peibiao2, CHEN Xuesi2, JING Xiabin2 |
| 1.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; Graduate University of Chinese Academy of Sciences, Beijing 100039, China; 2.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; |
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Abstract A series of segmented poly(L-lactide)-polyurethanes (PLA-PUs) were synthesized by a twostep method, with oligo-poly(L-lactide) (PLA) as the soft segments and the reaction product of 2,4-toluene diisocyanate (TDI) and ethylene glycol (EG) as the hard segments. The shape-memory properties and biocompatibility of PLA-PUs were examined. The 50% compressed PLA-PUs could recover almost 100% to their original shape within 10! from the lowest recovery temperature (22!-37!). In the recovery process the PLA-PU showed a maximum contracting stress in the range of 1.5-4 MPa. Cell incubation experiments show that PLA-PU has biocompatibility comparable to that of pure PLA. Therefore, this kind of polyurethane can be used for implanted medical devices with shape memory requirements.
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Issue Date: 05 December 2007
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