Synthesis of 3--methyl-D--inositol adenosine
analogues

doi:10.1007/s11458-008-0071-7

Front. Chem. China

2008, Vol. 3

Issue (4) : 464-466 https://doi.org/10.1007/s11458-008-0071-7

Synthesis of 3--methyl-D--inositol adenosine analogues

ZHAN Tianrong¹, YANG Huijuan²

1.College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology; 2.Teachers College of Qingdao University

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Abstract Using 3-O-methyl-D-chiro-inositol as starting material, the title compound 5 was synthesized by condensation of adenine and methanesulfonate 3. Additionally, compounds 8 and 9 were prepared through the opening of the epoxide ring in 7 by adenine. The key intermediate 7 was obtained in good yield via an epoxidation from mono-mesylate 6. The process of opening of epoxide ring appeared to be regioselective in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).

Issue Date: 05 December 2008

Cite this article:

YANG Huijuan,ZHAN Tianrong. Synthesis of 3--methyl-D--inositol adenosine analogues[J]. Front. Chem. China, 2008, 3(4): 464-466.

URL:

https://academic.hep.com.cn/fcc/EN/10.1007/s11458-008-0071-7
https://academic.hep.com.cn/fcc/EN/Y2008/V3/I4/464

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