Micellization and controlled release properties of methoxy poly(ethylene glycol)-<italic>b</italic>-poly(D,L-lactide-<italic>co</italic>-trimethylene carbonate)

doi:10.1007/s11458-009-0006-y

Front Chem Chin

2009, Vol. 4

Issue (1) : 104-109 https://doi.org/10.1007/s11458-009-0006-y

RESEARCH ARTICLE

Micellization and controlled release properties of methoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-trimethylene carbonate)

Jieming GAO, Yingzhi GUO, Zhongwei GU(

), Xingdong ZHANG

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China

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Abstract

Amphiphilic block copolymers composed of D,L-lactide, trimethylene carbonate and methoxy poly(ethylene glycol) (PETLA) were synthesized with ring-opening copolymerization. Studies on the micellization and drug-controlled release behavior of PETLA were performed. Both of the copolymers and the micelles were characterized with the methods of ¹H nuclear magnetic resonance (¹H-NMR), fluorescence spectroscopy, gel permeation chromatographic (GPC), dynamic light scattering (DLS), transmission electron microscopy (TEM) and ultraviolet-visible spectroscopy (UV). As a result, the critical micelle concentration of the copolymer was decreased with the increase of the hydrophobic chain length. DLS resulys indicated the diameters of the micelle were increased with increasing of hydrophobic length. TEM photographs illustrated that micelles MT1 were regularly spherical with the diameter from 30 nm to 40 nm. Taking 9-nitro-20(S)-camptothecin (9-NC) for the model drug, the release profiles in vitro show that the release behavior from micelles was controllable and nearly in zero order after the initial burst release.

Keywords biodegradable methoxy poly(ethylene glycol)-b-poly(D L-lactide-co-trimethylene carbonate) micelle controlled release

Corresponding Author(s): GU Zhongwei,Email:zwgu@scu.edu.cn

Issue Date: 05 March 2009

Cite this article:

Jieming GAO,Yingzhi GUO,Zhongwei GU, et al. Micellization and controlled release properties of methoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-trimethylene carbonate)[J]. Front Chem Chin, 2009, 4(1): 104-109.

URL:

https://academic.hep.com.cn/fcc/EN/10.1007/s11458-009-0006-y
https://academic.hep.com.cn/fcc/EN/Y2009/V4/I1/104

Tab.1 H-NMR and GPC characterization of PETLA copolymers

Fig.1 Synthesis of copolymer PETLA

Fig.2 H-NMR spectra of block copolymer PETLA2

Fig.3 Plots of the intensity ratio / from pyrene emission spectra versus concentrations (g/L) of copolymers from PETLA1 to PETLA4 in tri-distilled water

Fig.4 GPC chromatograms of micelle MT1, from which peak molecular weight of MT1 and PETLA1 were 241 919 and 2363 respectively

Tab.2 Micelles molecular weight and size analysis through GPC and DLS

Fig.5 Transmission electron micrographs of micelle MT1 composed of copolymer PETLA1

Fig.6 9-NC release profile from MT1 to MT4

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