6-O-(2-hydroxybutyl)-β-CD as a chiral selector
for nonaqueous capillary electrophoretic separation of chiral drugs

doi:10.1007/s11458-009-0038-3

Front. Chem. China

2009, Vol. 4

Issue (4) : 396-401 https://doi.org/10.1007/s11458-009-0038-3

Research articles

6-O-(2-hydroxybutyl)-β-CD as a chiral selector for nonaqueous capillary electrophoretic separation of chiral drugs

Wenguo XING¹,Yunhe WEI¹,Ping YU¹,Changqiao ZHANG¹,Jian LI²,

1.School ofChemistry and Chemical Engineering, Shandong University, Jinan 250100, China; 2.Shandong Analyses and Test Center, Jinan 250014, China;

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Abstract 6-O-(2-hydroxybutyl)-β-CD, as a new β-cyclodextrin (β-CD) derivative, was successfully synthesized. It was used as a chiral selector to separate six chiral drugs, including propranolol, anisodamine, promethazine, ketoconazole, benzhexol, and fenfluramine in nonaqueous capillary electrophoresis (NACE). The effects of the organic solvent, the electrolytes, the concentrations of cyclodextrin derivatives, and the pH of the buffer on the chiral resolution (Rs) were investigated. The baseline separation of enantiomers, including propranolol (Rs＝2.26), anisodamine (Rs＝2.31), promethazine (Rs＝2.42), ketoconazole (Rs＝2.56), benzhexol (Rs＝3.38), and fenfluramine (Rs＝3.04), could be achieved using a buffer of 100 mmol·L^−1 citric acid and 50 mmol·L^−1 Tris (hydroxymethyl) aminomethane (Tris) at pH 4.6 containing 100 mmol·L^−1 6-O-(2-hydroxybutyl)-β-CD in formamide (FA).

Keywords nonaqueous capillary electrophoresis enantiomer separation β-cyclodextrin derivatives chiral drugs

Issue Date: 05 December 2009

Cite this article:

Wenguo XING,Ping YU,Yunhe WEI, et al. 6-O-(2-hydroxybutyl)-β-CD as a chiral selector for nonaqueous capillary electrophoretic separation of chiral drugs[J]. Front. Chem. China, 2009, 4(4): 396-401.

URL:

https://academic.hep.com.cn/fcc/EN/10.1007/s11458-009-0038-3
https://academic.hep.com.cn/fcc/EN/Y2009/V4/I4/396

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