Polylactic acid (PLA) synthesis and modifications:
a review

doi:10.1007/s11458-009-0092-x

Front. Chem. China

2009, Vol. 4

Issue (3) : 259-264 https://doi.org/10.1007/s11458-009-0092-x

Research articles

Polylactic acid (PLA) synthesis and modifications: a review

Yanling CHENG ¹, Shaobo DENG ², Paul CHEN ², Roger RUAN ²,

1.China University of Mining and Technology, Beijing 100083, China；Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, 1390 Eckles Avenue, St. Paul, MN 55108, USA; 2.Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, 1390 Eckles Avenue, St. Paul, MN 55108, USA;

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Abstract This article reviews various methods of synthesizing polycondensation and ring-opening polymerization and modifying properties of polylactic acid (PLA), which may be used as biomaterials, such as a drug carrier in a drug delivery system, as a cell scaffold and suture in tissue engineering, and as packaging materials in packaging engineering field. Copolymerization of lactide with other monomers or polymers such as malic acid, polyethylene glycol (PEG), polyglycolic acid (PGA), or dextran, as well as blending polylactide with natural derivatives and other methods of modification are discussed. Surface modifications of PLA-type copolymers, such as surface coating, chemical modification, and plasma treatment are described.

Issue Date: 05 September 2009

Cite this article:

Shaobo DENG,Yanling CHENG,Paul CHEN, et al. Polylactic acid (PLA) synthesis and modifications: a review[J]. Front. Chem. China, 2009, 4(3): 259-264.

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https://academic.hep.com.cn/fcc/EN/10.1007/s11458-009-0092-x
https://academic.hep.com.cn/fcc/EN/Y2009/V4/I3/259

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