Chiral ruthenium-SDPs/diamine complexes-catalyzed
enantioselective hydrogenation of -alkyl arylacetones via dynamic kinetic resolution

doi:10.1007/s11458-009-0093-9

Front. Chem. China

2009, Vol. 4

Issue (3) : 299-306 https://doi.org/10.1007/s11458-009-0093-9

Research articles

Chiral ruthenium-SDPs/diamine complexes-catalyzed enantioselective hydrogenation of -alkyl arylacetones via dynamic kinetic resolution

Jianhua XIE , Weiling KONG , Xiaocheng WANG , Wenju BAI , Lixin WANG , Qilin ZHOU ,

State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China;

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Abstract The asymmetric hydrogenation of the conformationally flexible racemic α-substituted acyclic dialkyl ketones via dynamic kinetic resolution (DKR) has been developed by using Ru-SDPs/diamine catalysts. Chiral alcohols were produced in high yields with good to excellent enantioselectivities (85%―97% ee) and diastereoselectivities (up to 97:3). This hydrogenation reaction provided a new approach to the synthesis of the key intermediate of J-104118.

Keywords asymmetric hydrogenation arylacetones catalysis diphosphine diamine ruthenium

Issue Date: 05 September 2009

Cite this article:

Jianhua XIE,Weiling KONG,Xiaocheng WANG, et al. Chiral ruthenium-SDPs/diamine complexes-catalyzed enantioselective hydrogenation of -alkyl arylacetones via dynamic kinetic resolution[J]. Front. Chem. China, 2009, 4(3): 299-306.

URL:

https://academic.hep.com.cn/fcc/EN/10.1007/s11458-009-0093-9
https://academic.hep.com.cn/fcc/EN/Y2009/V4/I3/299

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